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Dideoxiadenosin
Hierarki: | ∟ ∟ ∟ ∟ ∟ ∟ ∟ Dideoxiadenosin 6 sidobegrepp∟ ∟ ∟ ∟ ∟ ∟ Dideoxiadenosin 6 sidobegrepp∟ ∟ ∟ ∟ ∟ ∟ Dideoxiadenosin 6 sidobegrepp∟ ∟ ∟ ∟ ∟ ∟ ∟ Dideoxiadenosin 6 sidobegrepp∟ ∟ ∟ ∟ ∟ ∟ ∟ Dideoxiadenosin 6 sidobegrepp∟ ∟ ∟ ∟ ∟ Dideoxiadenosin 6 sidobegrepp∟ ∟ ∟ ∟ ∟ Dideoxiadenosin 6 sidobegrepp∟ ∟ ∟ ∟ ∟ ∟ Dideoxiadenosin 6 sidobegrepp∟ ∟ ∟ ∟ ∟ ∟ Dideoxiadenosin 6 sidobegreppX |
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Anmärkning: | |
Anmärkning: | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite.
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Annotation: | an antiviral; inhibits HIV replication
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historyNote*: | 90
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publicMeSHNote*: | 90
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activeMeSHYear*: | 2007X |
dateCreated*: | 1989-07-14X |
dateEstablished*: | 1990-01-01X |
dateRevised*: | 2006-07-05X |
recordAuthorizer*: | sjnX |
recordMaintainer*: | ssbX |
recordOriginator*: | AGSX |
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Samordna villkor: | |
URI: | |
Termer och motsvarande begrepp: | Dideoksiadenosiini (fi) XDideoxyadenosine (en) ddA (Antiviral) (en, ersatt) 2',3'-Dideoxyadenosine (en, ersatt) |
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