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Kalsineuriini
Hierarkia: | |
Laajemmat termit: | |
Annotaatio: | a calcium- & calmodulin-binding protein in the CNS; DF: note short X ref
X |
historyNote*: | 98; see CALCINEURIN (NM) 1987-97
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Huomautus: | Calcium-Binding Proteins (1986-1997) | Calmodulin-Binding Proteins (1986-1997) | Phosphoprotein Phosphatase (1988-1997)X |
Huomautus: | A calcium- and calmodulin-binding protein present in highest concentrations in the central nervous system. Calcineurin is composed of two subunits. A catalytic subunit, calcineurin A, and a regulatory subunit, calcineurin B, with molecular weights of about 60 kDa and 19 kDa, respectively. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including histones, myosin light chain, and the regulatory subunit of cAMP-dependent protein kinase. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes in T-lymphocytes that act by inhibiting T-cell activation.
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publicMeSHNote*: | 98; CALCINEURIN was indexed under PHOSPHOPROTEIN PHOSPHATASE 1988-97 & CALMODULIN-BINDING PROTEINS 1986-97; CALCINEURIN B (now CALCINEURIN) was indexed under CALCIUM-BINDING PROTEINS 1994-97
X |
activeMeSHYear*: | |
dateCreated*: | 1997-06-20X |
dateEstablished*: | 1998-01-01X |
dateRevised*: | 2005-06-30X |
recordAuthorizer*: | sjnX |
recordMaintainer*: | agsX |
recordOriginator*: | ADPX |
Tyyppi: | |
Vierustermit: | |
URI: | |
Nimikkeet ja vastaavat käsitteet: | Kalcineurin (sv) XCalcineurin (en) Protein Phosphatase-2B (en, korvattu) Protein Phosphatase 2B (en, korvattu) PP2B (en, korvattu) |
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