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Näytä käsitteiden/termien suhteet:
Neuropiliinit
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historyNote*: | 2003; for NEUROPILIN use NEUROPILIN-1 (NM) 1998-2002
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Huomautus: | Nerve Tissue Proteins (1998-2002)X |
Huomautus: | Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance molecules during neural development and axonal outgrowth, and modulate VEGF-mediated angiogenesis. NEUROPILIN-1 and NEUROPILIN-2 differ in their binding specificities, and are distributed complementarily in regions of the developing nervous system. Neuropilins are receptors for secreted CLASS 3 SEMAPHORINS as well as for vascular endothelial growth factors, and may form hetero- or homodimers. They may also interact synergistically with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities and specificities. Neuropilin binding specificity is determined by CUB and coagulation-factor-like domains in the extracellular portion of the molecule, while a MAM domain is essential for SIGNAL TRANSDUCTION.
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publicMeSHNote*: | 2003; NEUROPILIN was indexed under NERVE TISSUE PROTEINS 1998-2002
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activeMeSHYear*: | |
dateCreated*: | 2002-07-03X |
dateEstablished*: | 2003-01-01X |
dateRevised*: | 2005-06-30X |
recordAuthorizer*: | sjnX |
recordMaintainer*: | jmpX |
recordOriginator*: | MDJX |
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Nimikkeet ja vastaavat käsitteet: | Neuropiliini (fi, korvattu) XNeuropiliner (sv) Neuropilins (en) Neuropilin (en, korvattu) |
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