Esitystapa käsitteiden/termien suhteille:
Näytä käsitteiden/termien suhteet:
Näytä käsitteiden/termien suhteet:
DNA-vaurio
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Annotaatio: | do not use /drug eff & /rad eff for DNA damage induced by drugs or radiation; do not confuse with DNA FRAGMENTATION: see note there
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historyNote*: | 87
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Huomautus: | DNA (1966-1986) DNA Repair (1971-1986) DNA Replication (1968-1986) |
Huomautus: | Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
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publicMeSHNote*: | 87
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activeMeSHYear*: | 2004 2005 2006 2007 |
dateCreated*: | 1986-06-19 |
dateEstablished*: | 1987-01-01 |
dateRevised*: | 2003-07-25 |
recordAuthorizer*: | sjn |
recordMaintainer*: | nns |
recordOriginator*: | SCD |
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Nimikkeet ja vastaavat käsitteet: | DNA-vauriot (fi, korvattu) DNA-skador (sv) DNA Damage (en) Stress, Genotoxic (en, korvattu) Injury, DNA (en, korvattu) DNA Injury (en, korvattu) |
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