ONKI3 | Medical Subject Headings

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The way property values are displayed: value/row values side by side

The way concept relations are shown: separately in hierarchy

Metabolic Detoxication, Phase I

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Biochemical Phenomena, Metabolism, and Nutrition ∟ Metabolism ∟ Pharmacokinetics ∟ Biotransformation ∟ Metabolic Detoxication, Drug ∟ Metabolic Detoxication, Phase I 1 coordinate concept ∟ Metabolic Detoxication, Phase II Medical Subject Headings (MeSH) ∟ Chemical and Pharmacologic Phenomena ∟ Biopharmaceutics ∟ Pharmacokinetics ∟ Biotransformation ∟ Metabolic Detoxication, Drug ∟ Metabolic Detoxication, Phase I 1 coordinate concept ∟ Metabolic Detoxication, Phase II X
Broader terms:	Medical Subject Headings (MeSH) ∟ Biochemical Phenomena, Metabolism, and Nutrition ∟ Metabolism ∟ Pharmacokinetics ∟ Biotransformation ∟ Metabolic Detoxication, Drug ∟ Metabolic Detoxication, Phase I Medical Subject Headings (MeSH) ∟ Chemical and Pharmacologic Phenomena ∟ Biopharmaceutics ∟ Pharmacokinetics ∟ Biotransformation ∟ Metabolic Detoxication, Drug ∟ Metabolic Detoxication, Phase I Metabolic Detoxication, Drug > Biotransformation > Pharmacokinetics > Metabolism > Biochemical Phenomena, Metabolism, and Nutrition > Medical Subject Headings (MeSH) Metabolic Detoxication, Drug > Biotransformation > Pharmacokinetics > Biopharmaceutics > Chemical and Pharmacologic Phenomena > Medical Subject Headings (MeSH) X
historyNote*:	2006 X
publicMeSHNote*:	2006 X
Scope note:	Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS. X
activeMeSHYear*:	2006 \| 2007X
dateCreated*:	2005-06-30X
dateEstablished*:	2006-01-01X
recordAuthorizer*:	sjnX
recordMaintainer*:	ssbX
recordOriginator*:	ssbX
Related term:	Drug Interactions X
Type:	Concept X
Coordinate terms:	Metabolic Detoxication, Phase II X
URI:	X
Labels and equivalent concepts:	Metabolinen detoksikaatio, vaihe I (fi) Phase I Detoxification (en, replaced) Metabolic Detoxification, Phase I (en, replaced) Metabolic Detoxication, Oxidative (en, replaced) X
Share:	X