ONKI3 | Medical Subject Headings

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Immunoglobulin Class Switching

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Biological Phenomena, Cell Phenomena, and Immunity ∟ Immunity ∟ Immunogenetics ∟ Gene Rearrangement, B-Lymphocyte ∟ Gene Rearrangement, B-Lymphocyte, Heavy Chain ∟ Immunoglobulin Class Switching Medical Subject Headings (MeSH) ∟ Biological Sciences ∟ Biology ∟ Genetics ∟ Immunogenetics ∟ Gene Rearrangement, B-Lymphocyte ∟ Gene Rearrangement, B-Lymphocyte, Heavy Chain ∟ Immunoglobulin Class Switching Medical Subject Headings (MeSH) ∟ Genetic Processes ∟ Gene Rearrangement ∟ Gene Rearrangement, B-Lymphocyte ∟ Gene Rearrangement, B-Lymphocyte, Heavy Chain ∟ Immunoglobulin Class Switching X
Broader terms:	Medical Subject Headings (MeSH) ∟ Biological Phenomena, Cell Phenomena, and Immunity ∟ Immunity ∟ Immunogenetics ∟ Gene Rearrangement, B-Lymphocyte ∟ Gene Rearrangement, B-Lymphocyte, Heavy Chain ∟ Immunoglobulin Class Switching Medical Subject Headings (MeSH) ∟ Biological Sciences ∟ Biology ∟ Genetics ∟ Immunogenetics ∟ Gene Rearrangement, B-Lymphocyte ∟ Gene Rearrangement, B-Lymphocyte, Heavy Chain ∟ Immunoglobulin Class Switching Medical Subject Headings (MeSH) ∟ Genetic Processes ∟ Gene Rearrangement ∟ Gene Rearrangement, B-Lymphocyte ∟ Gene Rearrangement, B-Lymphocyte, Heavy Chain ∟ Immunoglobulin Class Switching Gene Rearrangement, B-Lymphocyte, Heavy Chain > Gene Rearrangement, B-Lymphocyte > Immunogenetics > Immunity > Biological Phenomena, Cell Phenomena, and Immunity > Medical Subject Headings (MeSH) Gene Rearrangement, B-Lymphocyte, Heavy Chain > Gene Rearrangement, B-Lymphocyte > Immunogenetics > Genetics > Biology > Biological Sciences > Medical Subject Headings (MeSH) Gene Rearrangement, B-Lymphocyte, Heavy Chain > Gene Rearrangement, B-Lymphocyte > Gene Rearrangement > Genetic Processes > Medical Subject Headings (MeSH) X
History note:	Immunoglobulin Isotypes/biosynthesis (1988-1993) \| Immunoglobulins, Heavy-Chain/genetics (1980-1993)X
historyNote*:	94 X
publicMeSHNote*:	94 X
Scope note:	Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing. X
activeMeSHYear*:	2003 \| 2004 \| 2005 \| 2006 \| 2007X
dateCreated*:	1993-06-17X
dateEstablished*:	1994-01-01X
dateRevised*:	2002-07-03X
Type:	Concept X
URI:	X
Labels and equivalent concepts:	Immunoglobuliiniluokan vaihtuminen (fi) Immunoglobuliiniluokan vaihtaminen (fi, replaced) Antikroppsklassbyte (sv) Isotype Switching (en, replaced) Class Switching (en, replaced) X
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