ONKI3 | Medical Subject Headings

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Blood Proteins ∟ Immunoproteins ∟ Complement System Proteins ∟ Complement Activating Enzymes ∟ Complement C1r 4 coordinate concepts ∟ Complement C1q \| ∟ Complement C1s \| ∟ Complement C3-C5 Convertases \| ∟ Complement Factor D Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Blood Proteins ∟ Immunoproteins ∟ Complement System Proteins ∟ Complement C1 ∟ Complement C1r 4 coordinate concepts ∟ Complement C1q \| ∟ Complement C1s \| ∟ Complement C3-C5 Convertases \| ∟ Complement Factor D Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Hydrolases ∟ Complement Activating Enzymes ∟ Complement C1r 4 coordinate concepts ∟ Complement C1q \| ∟ Complement C1s \| ∟ Complement C3-C5 Convertases \| ∟ Complement Factor D X
Broader terms:	Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Blood Proteins ∟ Immunoproteins ∟ Complement System Proteins ∟ Complement Activating Enzymes ∟ Complement C1r Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Blood Proteins ∟ Immunoproteins ∟ Complement System Proteins ∟ Complement C1 ∟ Complement C1r Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Hydrolases ∟ Complement Activating Enzymes ∟ Complement C1r Complement Activating Enzymes > Complement System Proteins > Immunoproteins > Blood Proteins > Proteins > Amino Acids, Peptides, and Proteins > Medical Subject Headings (MeSH) Complement C1 > Complement System Proteins > Immunoproteins > Blood Proteins > Proteins > Amino Acids, Peptides, and Proteins > Medical Subject Headings (MeSH) Complement Activating Enzymes > Hydrolases > Enzymes > Enzymes and Coenzymes > Medical Subject Headings (MeSH) X
History note:	Complement 1 (1979-1989) \| Complement Activating Enzymes (1979-1989) \| Enzyme Precursors (1979-1982)X
historyNote*:	2006 (1990) X
publicMeSHNote*:	2006; see COMPLEMENT 1R 1990-2005 X
Scope note:	A 80-kDa subcomponent of complement C1, existing as a SERINE PROTEASE proenzyme in the intact complement C1 complex. When COMPLEMENT C1Q is bound to antibodies, the changed tertiary structure causes autolytic activation of complement C1r which is cleaved into two chains, A (heavy) and B (light, the serine protease), connected by disulfide bonds. The activated C1r serine protease, in turn, activates COMPLEMENT C1S proenzyme by cleaving the Arg426-Ile427 bond. No fragment is released when either C1r or C1s is cleaved. X
activeMeSHYear*:	2007X
dateCreated*:	1989-05-25X
dateEstablished*:	1990-01-01X
dateRevised*:	2006-07-05X
recordAuthorizer*:	sjnX
recordMaintainer*:	agsX
recordOriginator*:	AGSX
Type:	Concept X
Coordinate terms:	Complement C1q \| Complement C1s \| Complement C3-C5 Convertases \| Complement Factor D X
URI:	X
Labels and equivalent concepts:	Komplementti C1r (fi) C1r (fi, replaced) Komplement 1r (sv) Complement Component 1r (en, replaced) Complement 1r (en, replaced) C1r Complement (en, replaced) X
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