ONKI3 | Medical Subject Headings

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The way property values are displayed: value/row values side by side

The way concept relations are shown: separately in hierarchy

Spastic Paraplegia, Hereditary

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Abnormalities ∟ Nervous System Malformations ∟ Hereditary Motor and Sensory Neuropathies ∟ Spastic Paraplegia, Hereditary 2 coordinate concepts ∟ Charcot-Marie-Tooth Disease \| ∟ Refsum Disease Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Heredodegenerative Disorders, Nervous System ∟ Hereditary Motor and Sensory Neuropathies ∟ Spastic Paraplegia, Hereditary 2 coordinate concepts ∟ Charcot-Marie-Tooth Disease \| ∟ Refsum Disease Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Nervous System Malformations ∟ Hereditary Motor and Sensory Neuropathies ∟ Spastic Paraplegia, Hereditary 2 coordinate concepts ∟ Charcot-Marie-Tooth Disease \| ∟ Refsum Disease Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Neurodegenerative Diseases ∟ Heredodegenerative Disorders, Nervous System ∟ Hereditary Motor and Sensory Neuropathies ∟ Spastic Paraplegia, Hereditary 2 coordinate concepts ∟ Charcot-Marie-Tooth Disease \| ∟ Refsum Disease Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Neuromuscular Diseases ∟ Peripheral Nervous System Diseases ∟ Polyneuropathies ∟ Hereditary Motor and Sensory Neuropathies ∟ Spastic Paraplegia, Hereditary 2 coordinate concepts ∟ Charcot-Marie-Tooth Disease \| ∟ Refsum Disease X
Broader terms:	Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Abnormalities ∟ Nervous System Malformations ∟ Hereditary Motor and Sensory Neuropathies ∟ Spastic Paraplegia, Hereditary Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Heredodegenerative Disorders, Nervous System ∟ Hereditary Motor and Sensory Neuropathies ∟ Spastic Paraplegia, Hereditary Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Nervous System Malformations ∟ Hereditary Motor and Sensory Neuropathies ∟ Spastic Paraplegia, Hereditary Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Neurodegenerative Diseases ∟ Heredodegenerative Disorders, Nervous System ∟ Hereditary Motor and Sensory Neuropathies ∟ Spastic Paraplegia, Hereditary Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Neuromuscular Diseases ∟ Peripheral Nervous System Diseases ∟ Polyneuropathies ∟ Hereditary Motor and Sensory Neuropathies ∟ Spastic Paraplegia, Hereditary Hereditary Motor and Sensory Neuropathies > Nervous System Malformations > Abnormalities > Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Medical Subject Headings (MeSH) Hereditary Motor and Sensory Neuropathies > Heredodegenerative Disorders, Nervous System > Genetic Diseases, Inborn > Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Medical Subject Headings (MeSH) Hereditary Motor and Sensory Neuropathies > Nervous System Malformations > Nervous System Diseases > Medical Subject Headings (MeSH) Hereditary Motor and Sensory Neuropathies > Heredodegenerative Disorders, Nervous System > Neurodegenerative Diseases > Nervous System Diseases > Medical Subject Headings (MeSH) Hereditary Motor and Sensory Neuropathies > Polyneuropathies > Peripheral Nervous System Diseases > Neuromuscular Diseases > Nervous System Diseases > Medical Subject Headings (MeSH) X
Annotation:	coord with GENES, DOMINANT or GENES, RECESSIVE if discussed X
History note:	Muscle Spasticity/genetics (1975-1988) \| Paraplegia/genetics (1966-1988)X
historyNote*:	1991(1989) X
publicMeSHNote*:	1991; see NEUROPATHIES, HEREDITARY MOTOR AND SENSORY 1989-1990 X
Scope note:	A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8) X
activeMeSHYear*:	2005 \| 2005A \| 2006 \| 2007X
dateCreated*:	1988-06-07X
dateEstablished*:	1991-01-01X
dateRevised*:	2004-08-02X
recordAuthorizer*:	jlsX
recordMaintainer*:	jlsX
recordOriginator*:	ECX
Type:	Concept X
Coordinate terms:	Charcot-Marie-Tooth Disease \| Refsum Disease X
URI:	X
Labels and equivalent concepts:	Perinnöllinen spastinen paraplegia (fi) Periytyvä spastinen paraplegia (fi, replaced) Hereditaarinen spastinen paraplegia (fi, replaced) Spastisk paraplegi, ärftlig (sv) Ärflig spastisk paraplegi (sv, replaced) Spastic Paraplegia, Hereditary, Autosomal Recessive (en, replaced) Spastic Paraplegia, Hereditary, X-Linked Recessive (en, replaced) Spastic Paraplegia, Hereditary, Autosomal Dominant (en, replaced) Spastic Paraplegia, Autosomal Recessive, Hereditary (en, replaced) Spastic Paraplegia, Autosomal Dominant, Hereditary (en, replaced) Spastic Paraplegia, X-Linked Recessive, Hereditary (en, replaced) Type V Hereditary Motor and Sensory Neuropathy (en, replaced) X-linked Recessive Hereditary Spastic Paraplegia (en, replaced) Spastic Paraplegia-Hypertrophic Motor-Sensory Neuropathy (en, replaced) Paraplegia, Spastic, Hereditary (en, replaced) Hereditary Motor-Sensory Neuropathy with Pyramidal Signs (en, replaced) Hereditary Spastic Paraplegia (en, replaced) Hereditary Autosomal Recessive Spastic Paraplegia (en, replaced) Autosomal Recessive Spastic Paraplegia, Hereditary (en, replaced) Autosomal Dominant Spastic Paraplegia Hereditary (en, replaced) Hereditary Spastic Paraplegia, Autosomal Recessive (en, replaced) Hereditary, Spastic Paraplegia, Autosomal Dominant (en, replaced) Hypertrophic Motor-Sensory Neuropathy-Spastic Paraplegia (en, replaced) HMSN V (Hereditary Motor and Sensory Neuropathy Type V) (en, replaced) HMSN Type V (en, replaced) Hereditary, Spastic Paraplegia, X-Linked Recessive (en, replaced) Autosomal Dominant Hereditary Spastic Paraplegia (en, replaced) Paraplegia spastica hereditaria (la-FI, replaced) X
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