ONKI3 | Medical Subject Headings

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beta-N-Acetylhexosaminidase

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Hydrolases ∟ Glycoside Hydrolases ∟ Hexosaminidases ∟ beta-N-Acetylhexosaminidase 4 coordinate concepts ∟ Acetylglucosaminidase \| ∟ alpha-N-Acetylgalactosaminidase \| ∟ beta-N-Acetyl-Galactosaminidase \| ∟ Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase X
Broader terms:	Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Hydrolases ∟ Glycoside Hydrolases ∟ Hexosaminidases ∟ beta-N-Acetylhexosaminidase Hexosaminidases > Glycoside Hydrolases > Hydrolases > Enzymes > Enzymes and Coenzymes > Medical Subject Headings (MeSH) X
Annotation:	do not confuse with ACETYLGLUCOSAMINIDASE; /defic: consider also TAY SACHS DISEASE and SANDHOFF DISEASE; coord with ISOENZYMES if discussed X
History note:	Glycoside Hydrolases (1966-1970) \| Hexosaminidases (1971-1986)X
historyNote*:	87 X
publicMeSHNote*:	87 X
Scope note:	An enzyme hydrolyzing terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. It acts on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES. Hexosaminidase A cleaves GM2, GA2, globosides, and hexosamine oligosaccharides. Hexosaminidase B cleaves all the above substrates except GM2. Deficiency of Hexosaminidase A causes TAY-SACHS DISEASE, while deficiency of both A and B isozymes causes SANDHOFF DISEASE. The enzyme has also been used as a tumor marker to distinguish between malignant and benign disease. X
activeMeSHYear*:	2005 \| 2006 \| 2006A \| 2007X
dateCreated*:	1986-06-02X
dateEstablished*:	1987-01-01X
dateRevised*:	2005-07-15X
recordAuthorizer*:	agsX
recordMaintainer*:	agsX
recordOriginator*:	RLSX
Related term:	Sandhoff Disease \| Tay-Sachs Disease X
Type:	Concept X
Coordinate terms:	Acetylglucosaminidase \| alpha-N-Acetylgalactosaminidase \| beta-N-Acetyl-Galactosaminidase \| Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase X
URI:	X
Labels and equivalent concepts:	Beeta-N-asetyyliheksoaminidaasi (fi) beta-N-acetylhexosaminidas (sv) Hex B (en, replaced) N-Acetyl-beta-D-hexosaminidase (en, replaced) Hex A (en, replaced) beta-N-Acetylhexosaminidase A (en, replaced) beta-N-Acetyl-D-hexosaminidase (en, replaced) beta-N-Acetyl-hexosaminidase (en, replaced) beta-Hexosaminidase (en, replaced) X
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