ONKI3 | Medical Subject Headings

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Tay-Sachs Disease, AB Variant

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Metabolism, Inborn Errors ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidoses, GM2 ∟ Tay-Sachs Disease, AB Variant 2 coordinate concepts ∟ Sandhoff Disease \| ∟ Tay-Sachs Disease Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Metabolism, Inborn Errors ∟ Lipid Metabolism, Inborn Errors ∟ Lipidoses ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidoses, GM2 ∟ Tay-Sachs Disease, AB Variant 2 coordinate concepts ∟ Sandhoff Disease \| ∟ Tay-Sachs Disease Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Metabolism, Inborn Errors ∟ Lysosomal Storage Diseases ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidoses, GM2 ∟ Tay-Sachs Disease, AB Variant 2 coordinate concepts ∟ Sandhoff Disease \| ∟ Tay-Sachs Disease Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Central Nervous System Diseases ∟ Brain Diseases ∟ Brain Diseases, Metabolic ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidoses, GM2 ∟ Tay-Sachs Disease, AB Variant 2 coordinate concepts ∟ Sandhoff Disease \| ∟ Tay-Sachs Disease Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Brain Diseases, Metabolic ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidoses, GM2 ∟ Tay-Sachs Disease, AB Variant 2 coordinate concepts ∟ Sandhoff Disease \| ∟ Tay-Sachs Disease Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Lipid Metabolism Disorders ∟ Lipidoses ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidoses, GM2 ∟ Tay-Sachs Disease, AB Variant 2 coordinate concepts ∟ Sandhoff Disease \| ∟ Tay-Sachs Disease Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Metabolism, Inborn Errors ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidoses, GM2 ∟ Tay-Sachs Disease, AB Variant 2 coordinate concepts ∟ Sandhoff Disease \| ∟ Tay-Sachs Disease Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Metabolism, Inborn Errors ∟ Lipid Metabolism, Inborn Errors ∟ Lipidoses ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidoses, GM2 ∟ Tay-Sachs Disease, AB Variant 2 coordinate concepts ∟ Sandhoff Disease \| ∟ Tay-Sachs Disease Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Metabolism, Inborn Errors ∟ Lysosomal Storage Diseases ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidoses, GM2 ∟ Tay-Sachs Disease, AB Variant 2 coordinate concepts ∟ Sandhoff Disease \| ∟ Tay-Sachs Disease X
Broader terms:	Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Metabolism, Inborn Errors ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidoses, GM2 ∟ Tay-Sachs Disease, AB Variant Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Metabolism, Inborn Errors ∟ Lipid Metabolism, Inborn Errors ∟ Lipidoses ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidoses, GM2 ∟ Tay-Sachs Disease, AB Variant Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Metabolism, Inborn Errors ∟ Lysosomal Storage Diseases ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidoses, GM2 ∟ Tay-Sachs Disease, AB Variant Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Central Nervous System Diseases ∟ Brain Diseases ∟ Brain Diseases, Metabolic ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidoses, GM2 ∟ Tay-Sachs Disease, AB Variant Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Brain Diseases, Metabolic ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidoses, GM2 ∟ Tay-Sachs Disease, AB Variant Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Lipid Metabolism Disorders ∟ Lipidoses ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidoses, GM2 ∟ Tay-Sachs Disease, AB Variant Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Metabolism, Inborn Errors ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidoses, GM2 ∟ Tay-Sachs Disease, AB Variant Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Metabolism, Inborn Errors ∟ Lipid Metabolism, Inborn Errors ∟ Lipidoses ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidoses, GM2 ∟ Tay-Sachs Disease, AB Variant Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Metabolism, Inborn Errors ∟ Lysosomal Storage Diseases ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidoses, GM2 ∟ Tay-Sachs Disease, AB Variant Gangliosidoses, GM2 > Gangliosidoses > Sphingolipidoses > Lysosomal Storage Diseases, Nervous System > Brain Diseases, Metabolic, Inborn > Metabolism, Inborn Errors > Genetic Diseases, Inborn > Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Medical Subject Headings (MeSH) Gangliosidoses, GM2 > Gangliosidoses > Sphingolipidoses > Lipidoses > Lipid Metabolism, Inborn Errors > Metabolism, Inborn Errors > Genetic Diseases, Inborn > Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Medical Subject Headings (MeSH) Gangliosidoses, GM2 > Gangliosidoses > Sphingolipidoses > Lysosomal Storage Diseases, Nervous System > Lysosomal Storage Diseases > Metabolism, Inborn Errors > Genetic Diseases, Inborn > Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Medical Subject Headings (MeSH) Gangliosidoses, GM2 > Gangliosidoses > Sphingolipidoses > Lysosomal Storage Diseases, Nervous System > Brain Diseases, Metabolic, Inborn > Brain Diseases, Metabolic > Brain Diseases > Central Nervous System Diseases > Nervous System Diseases > Medical Subject Headings (MeSH) Gangliosidoses, GM2 > Gangliosidoses > Sphingolipidoses > Lysosomal Storage Diseases, Nervous System > Brain Diseases, Metabolic, Inborn > Brain Diseases, Metabolic > Metabolic Diseases > Nutritional and Metabolic Diseases > Medical Subject Headings (MeSH) Gangliosidoses, GM2 > Gangliosidoses > Sphingolipidoses > Lipidoses > Lipid Metabolism Disorders > Metabolic Diseases > Nutritional and Metabolic Diseases > Medical Subject Headings (MeSH) Gangliosidoses, GM2 > Gangliosidoses > Sphingolipidoses > Lysosomal Storage Diseases, Nervous System > Brain Diseases, Metabolic, Inborn > Metabolism, Inborn Errors > Metabolic Diseases > Nutritional and Metabolic Diseases > Medical Subject Headings (MeSH) Gangliosidoses, GM2 > Gangliosidoses > Sphingolipidoses > Lipidoses > Lipid Metabolism, Inborn Errors > Metabolism, Inborn Errors > Metabolic Diseases > Nutritional and Metabolic Diseases > Medical Subject Headings (MeSH) Gangliosidoses, GM2 > Gangliosidoses > Sphingolipidoses > Lysosomal Storage Diseases, Nervous System > Lysosomal Storage Diseases > Metabolism, Inborn Errors > Metabolic Diseases > Nutritional and Metabolic Diseases > Medical Subject Headings (MeSH) X
History note:	Gangliosidoses (2000-2004)X
historyNote*:	2005(2000); use GANGLIOSIDOSES GM2 2000-2004 X
publicMeSHNote*:	2005; see GANGLIOSIDOSES GM2 2000-2004 X
Scope note:	A progressive neurodegenerative disorder that begins with muscle weakness, then progresses to startle reaction, retardation and seizures. It is characterized by the accumulation of G(M2) GANGLIOSIDE in neurons that is caused by a lack of G(M2) ACTIVATOR PROTEIN function. The AB variant designation refers to the increase of both HEXOSAMINIDASE A and HEXOSAMINIDASE B in tissues that lack of G(M2) activator protein. X
activeMeSHYear*:	2007X
dateCreated*:	2004-07-07X
dateEstablished*:	2005-01-01X
dateRevised*:	2006-07-05X
recordAuthorizer*:	sjnX
recordMaintainer*:	lktX
recordOriginator*:	jmpX
Related term:	G(M2) Activator Protein X
Type:	Concept X
Coordinate terms:	Sandhoff Disease \| Tay-Sachs Disease X
URI:	X
Labels and equivalent concepts:	Tay-Sachsin taudin AB-variantti (fi) Gangliosidoosi GM2, AB-tyyppi (fi, replaced) Gangliosidoosi GM2, AB-variantti (fi, replaced) Tay-Sachsin taudin AB-tyyppi (fi, replaced) Hexosaminidase Activator Protein Deficiency Disease (en, replaced) GM2 Protein Activator Deficiency Disease (en, replaced) GM2 Activator Deficiency Disease (en, replaced) Deficiency Disease, GM2 Protein Activator (en, replaced) Gangliosidosis GM2, AB Variant (en, replaced) Gangliosidosis GM2, Type AB (en, replaced) AB Variant Gangliosidosis GM2 (en, replaced) X
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