ONKI3 | Medical Subject Headings

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MAP Kinase Signaling System

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Biochemical Phenomena, Metabolism, and Nutrition ∟ Biochemical Phenomena ∟ Signal Transduction ∟ MAP Kinase Signaling System 5 coordinate concepts ∟ Ion Channel Gating \| ∟ Mechanotransduction, Cellular \| ∟ Phototransduction \| ∟ Second Messenger Systems \| ∟ Synaptic Transmission Medical Subject Headings (MeSH) ∟ Biological Phenomena, Cell Phenomena, and Immunity ∟ Cell Physiology ∟ Cell Communication ∟ Signal Transduction ∟ MAP Kinase Signaling System 5 coordinate concepts ∟ Ion Channel Gating \| ∟ Mechanotransduction, Cellular \| ∟ Phototransduction \| ∟ Second Messenger Systems \| ∟ Synaptic Transmission Medical Subject Headings (MeSH) ∟ Biological Phenomena, Cell Phenomena, and Immunity ∟ Cell Physiology ∟ Signal Transduction ∟ MAP Kinase Signaling System 5 coordinate concepts ∟ Ion Channel Gating \| ∟ Mechanotransduction, Cellular \| ∟ Phototransduction \| ∟ Second Messenger Systems \| ∟ Synaptic Transmission Medical Subject Headings (MeSH) ∟ Physiological Processes ∟ Cell Physiology ∟ Cell Communication ∟ Signal Transduction ∟ MAP Kinase Signaling System 5 coordinate concepts ∟ Ion Channel Gating \| ∟ Mechanotransduction, Cellular \| ∟ Phototransduction \| ∟ Second Messenger Systems \| ∟ Synaptic Transmission Medical Subject Headings (MeSH) ∟ Physiological Processes ∟ Cell Physiology ∟ Signal Transduction ∟ MAP Kinase Signaling System 5 coordinate concepts ∟ Ion Channel Gating \| ∟ Mechanotransduction, Cellular \| ∟ Phototransduction \| ∟ Second Messenger Systems \| ∟ Synaptic Transmission X
Broader terms:	Medical Subject Headings (MeSH) ∟ Biochemical Phenomena, Metabolism, and Nutrition ∟ Biochemical Phenomena ∟ Signal Transduction ∟ MAP Kinase Signaling System Medical Subject Headings (MeSH) ∟ Biological Phenomena, Cell Phenomena, and Immunity ∟ Cell Physiology ∟ Cell Communication ∟ Signal Transduction ∟ MAP Kinase Signaling System Medical Subject Headings (MeSH) ∟ Biological Phenomena, Cell Phenomena, and Immunity ∟ Cell Physiology ∟ Signal Transduction ∟ MAP Kinase Signaling System Medical Subject Headings (MeSH) ∟ Physiological Processes ∟ Cell Physiology ∟ Cell Communication ∟ Signal Transduction ∟ MAP Kinase Signaling System Medical Subject Headings (MeSH) ∟ Physiological Processes ∟ Cell Physiology ∟ Signal Transduction ∟ MAP Kinase Signaling System Signal Transduction > Biochemical Phenomena > Biochemical Phenomena, Metabolism, and Nutrition > Medical Subject Headings (MeSH) Signal Transduction > Cell Communication > Cell Physiology > Biological Phenomena, Cell Phenomena, and Immunity > Medical Subject Headings (MeSH) Signal Transduction > Cell Physiology > Biological Phenomena, Cell Phenomena, and Immunity > Medical Subject Headings (MeSH) Signal Transduction > Cell Communication > Cell Physiology > Physiological Processes > Medical Subject Headings (MeSH) Signal Transduction > Cell Physiology > Physiological Processes > Medical Subject Headings (MeSH) X
History note:	Ca(2+)-Calmodulin Dependent Protein Kinase (1994-1999) \| Protein Kinases (1989-1999) \| Protein-Serine-Threonine Kinases (1993-1999) \| Protein-Tyrosine Kinase (1989-1999)X
historyNote*:	2000 X
publicMeSHNote*:	2000 X
Scope note:	An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade. X
activeMeSHYear*:	2005 \| 2006 \| 2007X
dateCreated*:	1999-11-05X
dateEstablished*:	2000-01-01X
dateRevised*:	2004-07-07X
recordAuthorizer*:	sjnX
recordMaintainer*:	jmpX
recordOriginator*:	nnsX
Related term:	MAP Kinase Kinase Kinases \| Mitogen-Activated Protein Kinase Kinases \| Mitogen-Activated Protein Kinases X
Type:	Concept X
Coordinate terms:	Ion Channel Gating \| Mechanotransduction, Cellular \| Phototransduction \| Second Messenger Systems \| Synaptic Transmission X
URI:	X
Labels and equivalent concepts:	MAP-kinaasisignaalijärjestelmä (fi) MAP-kinaasikaskadi (fi, replaced) MAP Kinase Signaling Cascades (en, replaced) MAP Kinase Modules (en, replaced) X
Share:	X