ONKI3 | Medical Subject Headings

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Chemical Actions and Uses ∟ Pharmacologic Actions ∟ Molecular Mechanisms of Action ∟ Neurotransmitter Agents ∟ GABA Agents ∟ GABA Modulators 2 coordinate concepts ∟ GABA Agonists \| ∟ GABA Antagonists Medical Subject Headings (MeSH) ∟ Chemical Actions and Uses ∟ Pharmacologic Actions ∟ Physiological Effects of Drugs ∟ Neurotransmitter Agents ∟ GABA Agents ∟ GABA Modulators 2 coordinate concepts ∟ GABA Agonists \| ∟ GABA Antagonists X
Broader terms:	Medical Subject Headings (MeSH) ∟ Chemical Actions and Uses ∟ Pharmacologic Actions ∟ Molecular Mechanisms of Action ∟ Neurotransmitter Agents ∟ GABA Agents ∟ GABA Modulators Medical Subject Headings (MeSH) ∟ Chemical Actions and Uses ∟ Pharmacologic Actions ∟ Physiological Effects of Drugs ∟ Neurotransmitter Agents ∟ GABA Agents ∟ GABA Modulators GABA Agents > Neurotransmitter Agents > Molecular Mechanisms of Action > Pharmacologic Actions > Chemical Actions and Uses > Medical Subject Headings (MeSH) GABA Agents > Neurotransmitter Agents > Physiological Effects of Drugs > Pharmacologic Actions > Chemical Actions and Uses > Medical Subject Headings (MeSH) X
Annotation:	GEN or unspecified; prefer specifics X
historyNote*:	95 X
publicMeSHNote*:	95 X
Scope note:	Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. X
activeMeSHYear*:	2006 \| 2007X
dateCreated*:	1994-06-03X
dateEstablished*:	1995-01-01X
dateRevised*:	2005-06-30X
recordAuthorizer*:	sjnX
recordMaintainer*:	ssbX
recordOriginator*:	RAZX
Related term:	Anesthetics, General \| Anti-Anxiety Agents \| Hypnotics and Sedatives X
Type:	Concept X
Coordinate terms:	GABA Agonists \| GABA Antagonists X
URI:	X
Labels and equivalent concepts:	GABA-muuntajat (fi) Gamma-aminovoihappomodulaattorit (fi, replaced) Gamma-aminovoihappomuuntaja (fi, replaced) Gamma-aminovoihappomuuntajat (fi, replaced) Gamma-aminovoihappomodulaattori (fi, replaced) GABA-muuntaja (fi, replaced) GABA-modulaattori (fi, replaced) GABA-modulaattorit (fi, replaced) GABA-modulatorer (sv) gamma-Aminobutyric Acid Modulators (en, replaced) GABAergic Modulators (en, replaced) X
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