ONKI3 | Medical Subject Headings

The ONKI is provided as a part of the ONKI Living Lab - an open lab for testing the latest semantic web technologies in practice, with real users like you. Currently, over 10 000 people are using ONKI each month.

We hope you like the ONKI service and enjoy using it for your purposes!

If you encounter any problems or have improvement ideas, please contact the ONKI team. We are also very much interested in your success stories in using ONKI - please share your experiences!

The ONKI Team

Jouni Tuominen, Living Lab contact person, APIs, widgets, publishing of ontologies, etc.
Eero Hyvönen, professor, head of research group

Former members: Kim Viljanen, Rami Alatalo.

Building the future of the Semantic Web and beyond.

SeCo's homepage
For the latest semantic news, follow us on Twitter and fan us on Facebook!

How can we help you?

Live presentations about ONKI: what it is? how to use it?
Support for creating and publishing ontologies.
Online technical support for using ONKI.
Co-operation in projects.
And more, please ask.

suomeksi på svenska in English

The way property values are displayed: value/row values side by side

The way concept relations are shown: separately in hierarchy

Steroid 12-alpha-Hydroxylase

Loading results...


Hierarchy:	Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Hemeproteins ∟ Cytochromes ∟ Cytochrome P-450 Enzyme System ∟ Steroid Hydroxylases ∟ Steroid 12-alpha-Hydroxylase 10 coordinate concepts ∟ 25-Hydroxyvitamin D3 1-alpha-Hydroxylase \| ∟ Aldosterone Synthase \| ∟ Aromatase \| ∟ Cholesterol 7-alpha-Hydroxylase \| ∟ Cholesterol Side-Chain Cleavage Enzyme \| ∟ Cytochrome P-450 CYP27A1 \| ∟ Steroid 11-beta-Hydroxylase \| ∟ Steroid 16-alpha-Hydroxylase \| ∟ Steroid 17-alpha-Hydroxylase \| ∟ Steroid 21-Hydroxylase Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Cytochromes ∟ Cytochrome P-450 Enzyme System ∟ Steroid Hydroxylases ∟ Steroid 12-alpha-Hydroxylase 10 coordinate concepts ∟ 25-Hydroxyvitamin D3 1-alpha-Hydroxylase \| ∟ Aldosterone Synthase \| ∟ Aromatase \| ∟ Cholesterol 7-alpha-Hydroxylase \| ∟ Cholesterol Side-Chain Cleavage Enzyme \| ∟ Cytochrome P-450 CYP27A1 \| ∟ Steroid 11-beta-Hydroxylase \| ∟ Steroid 16-alpha-Hydroxylase \| ∟ Steroid 17-alpha-Hydroxylase \| ∟ Steroid 21-Hydroxylase Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Oxidoreductases ∟ Oxygenases ∟ Mixed Function Oxygenases ∟ Cytochrome P-450 Enzyme System ∟ Steroid Hydroxylases ∟ Steroid 12-alpha-Hydroxylase 10 coordinate concepts ∟ 25-Hydroxyvitamin D3 1-alpha-Hydroxylase \| ∟ Aldosterone Synthase \| ∟ Aromatase \| ∟ Cholesterol 7-alpha-Hydroxylase \| ∟ Cholesterol Side-Chain Cleavage Enzyme \| ∟ Cytochrome P-450 CYP27A1 \| ∟ Steroid 11-beta-Hydroxylase \| ∟ Steroid 16-alpha-Hydroxylase \| ∟ Steroid 17-alpha-Hydroxylase \| ∟ Steroid 21-Hydroxylase Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Oxidoreductases ∟ Oxygenases ∟ Mixed Function Oxygenases ∟ Steroid Hydroxylases ∟ Steroid 12-alpha-Hydroxylase 10 coordinate concepts ∟ 25-Hydroxyvitamin D3 1-alpha-Hydroxylase \| ∟ Aldosterone Synthase \| ∟ Aromatase \| ∟ Cholesterol 7-alpha-Hydroxylase \| ∟ Cholesterol Side-Chain Cleavage Enzyme \| ∟ Cytochrome P-450 CYP27A1 \| ∟ Steroid 11-beta-Hydroxylase \| ∟ Steroid 16-alpha-Hydroxylase \| ∟ Steroid 17-alpha-Hydroxylase \| ∟ Steroid 21-Hydroxylase X
Broader terms:	Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Hemeproteins ∟ Cytochromes ∟ Cytochrome P-450 Enzyme System ∟ Steroid Hydroxylases ∟ Steroid 12-alpha-Hydroxylase Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Cytochromes ∟ Cytochrome P-450 Enzyme System ∟ Steroid Hydroxylases ∟ Steroid 12-alpha-Hydroxylase Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Oxidoreductases ∟ Oxygenases ∟ Mixed Function Oxygenases ∟ Cytochrome P-450 Enzyme System ∟ Steroid Hydroxylases ∟ Steroid 12-alpha-Hydroxylase Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Oxidoreductases ∟ Oxygenases ∟ Mixed Function Oxygenases ∟ Steroid Hydroxylases ∟ Steroid 12-alpha-Hydroxylase Steroid Hydroxylases > Cytochrome P-450 Enzyme System > Cytochromes > Hemeproteins > Proteins > Amino Acids, Peptides, and Proteins > Medical Subject Headings (MeSH) Steroid Hydroxylases > Cytochrome P-450 Enzyme System > Cytochromes > Enzymes and Coenzymes > Medical Subject Headings (MeSH) Steroid Hydroxylases > Cytochrome P-450 Enzyme System > Mixed Function Oxygenases > Oxygenases > Oxidoreductases > Enzymes > Enzymes and Coenzymes > Medical Subject Headings (MeSH) Steroid Hydroxylases > Mixed Function Oxygenases > Oxygenases > Oxidoreductases > Enzymes > Enzymes and Coenzymes > Medical Subject Headings (MeSH) X
History note:	Steroid Hydroxylases (1973-1977)X
historyNote*:	2003 (1978) X
publicMeSHNote*:	2003; see STEROID 12-MONOOXYGENASE 1997-2002, see STEROID 12-HYDROXYLASE 1991-1996, see STEROID HYDROXYLASES 1978-1990; for STEROID 12-MONOOXYGENASE see STEROID 12-HYDROXYLASE 1978-1996 X
Scope note:	A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol. X
activeMeSHYear*:	2005 \| 2006 \| 2007X
dateCreated*:	1977-04-15X
dateEstablished*:	1991-01-01X
dateRevised*:	2004-07-07X
recordAuthorizer*:	sjnX
recordMaintainer*:	ssbX
recordOriginator*:	RLSX
Type:	Concept X
Coordinate terms:	25-Hydroxyvitamin D3 1-alpha-Hydroxylase \| Aldosterone Synthase \| Aromatase \| Cholesterol 7-alpha-Hydroxylase \| Cholesterol Side-Chain Cleavage Enzyme \| Cytochrome P-450 CYP27A1 \| Steroid 11-beta-Hydroxylase \| Steroid 16-alpha-Hydroxylase \| Steroid 17-alpha-Hydroxylase \| Steroid 21-Hydroxylase X
URI:	X
Labels and equivalent concepts:	Steroidi-12-alfa-hydroksylaasi (fi) Steroid-12-monooxygenas (sv) Steroid-12-Hydroxylase (en, replaced) Steroid-12-Monooxygenase (en, replaced) Sterol 12 alpha-Hydroxylase (en, replaced) Sterol 12-alpha-Hydroxylase (en, replaced) Steroid 12-Monooxygenase (en, replaced) Steroid 12-Hydroxylase (en, replaced) 12alpha-Hydroxylase (en, replaced) CYP8B1 (en, replaced) Cytochrome P450 8B1 (en, replaced) Cytochrome P450 CYP8B1 (en, replaced) 12-alpha-Hydroxylase (en, replaced) X
Share:	X