ONKI3 | Medical Subject Headings

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Blood Proteins ∟ Immunoproteins ∟ Complement System Proteins ∟ Complement C5 15 coordinate concepts 2 subordinate concepts ∟ Complement C5a \| ∟ Complement C5b ∟ Anaphylatoxins \| ∟ Complement Activating Enzymes \| ∟ Complement C1 \| ∟ Complement C2 \| ∟ Complement C3 \| ∟ Complement C4 \| ∟ Complement C6 \| ∟ Complement C7 \| ∟ Complement C8 \| ∟ Complement C9 \| ∟ Complement Factor B \| ∟ Complement Inactivator Proteins \| ∟ Complement Membrane Attack Complex \| ∟ D003165Q000037* \| ∟ Properdin X
Broader terms:	Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Blood Proteins ∟ Immunoproteins ∟ Complement System Proteins ∟ Complement C5 Complement System Proteins > Immunoproteins > Blood Proteins > Proteins > Amino Acids, Peptides, and Proteins > Medical Subject Headings (MeSH) X
Narrower terms:	Complement C5a \| Complement C5b X
History note:	Complement (1968-1974) \| Histamine Liberation (1966-1974)X
historyNote*:	2006 (1975) X
publicMeSHNote*:	2006; see COMPLEMENT 5 1978-2005, see COMPLEMENT 1975-1977; COMPLEMENT C5, PRECURSOR was indexed under COMPLEMENT 5 1991-2005 X
Scope note:	C5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT C5A and COMPLEMENT C5B. The smaller fragment C5a is an ANAPHYLATOXIN and mediator of inflammatory process. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the MEMBRANE ATTACK COMPLEX. X
activeMeSHYear*:	2006 \| 2006A \| 2007X
dateCreated*:	1974-11-11X
dateEstablished*:	1978-01-01X
dateRevised*:	2005-07-11X
recordAuthorizer*:	agsX
recordMaintainer*:	agsX
recordOriginator*:	NLMX
Type:	Concept X
Coordinate terms:	Anaphylatoxins \| Complement Activating Enzymes \| Complement C1 \| Complement C2 \| Complement C3 \| Complement C4 \| Complement C6 \| Complement C7 \| Complement C8 \| Complement C9 \| Complement Factor B \| Complement Inactivator Proteins \| Complement Membrane Attack Complex \| D003165Q000037* \| Properdin X
URI:	X
Labels and equivalent concepts:	Komplementti C5 (fi) C5 (fi, replaced) Komplement 5 (sv) Pro-complement 5 (en, replaced) Pro-C5 (en, replaced) Precursor C5 (en, replaced) Complement 5 (en, replaced) Complement Component 5 (en, replaced) C5 Complement (en, replaced) X
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