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The way concept relations are shown:
Activin Receptors
Hierarchy: | ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ Activin Receptors 23 coordinate concepts2 subordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ Activin Receptors 23 coordinate concepts2 subordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ Activin Receptors 23 coordinate concepts2 subordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ |
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historyNote*: | 2002; use ACTIVIN RECEPTORS (NM) 1991-2001
X |
publicMeSHNote*: | 2002; ACTIVIN RECEPTORS was indexed under RECEPTORS, GROWTH FACTOR
X |
Scope note: | Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). Activin receptors also bind TRANSFORMING GROWTH FACTOR BETA. As those transmembrane receptors of the TGF-beta superfamily (RECEPTORS, TRANSFORMING GROWTH FACTOR BETA), ALK's consist of two different but related protein kinases, Type I and Type II. Activins initiate cellular signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS, TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS, TYPE I ) with subsequent activation of the type I kinase activity.
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activeMeSHYear*: | |
dateCreated*: | 2001-07-25X |
dateEstablished*: | 2002-01-01X |
dateRevised*: | 2003-07-09X |
recordAuthorizer*: | sjnX |
recordMaintainer*: | ssbX |
recordOriginator*: | lktX |
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Labels and equivalent concepts: | Aktiviinireseptorit (fi) XAktiviinireseptori (fi, replaced) Receptor, Activin (en, replaced) Activin Receptor-Like Kinases (en, replaced) Activin Receptor-like Kinase (en, replaced) Activin Receptor (en, replaced) |
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