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Disintegrins
Hierarchy: | ∟ ∟ ∟ Disintegrins 30 coordinate conceptsX |
Broader terms: | |
Annotation: | polypeptides from snake venom; platelet aggregation inhib
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History note: | |
historyNote*: | 97; was DISINTEGRINS (NM) 1992-96
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onlineNote*: | use DISINTEGRINS (NM) to search DISINTEGRINS 1992-96
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publicMeSHNote*: | 97; DISINTEGRINS was indexed under PEPTIDES 1992-96 & VENOMS 1992-94
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Scope note: | A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors.
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activeMeSHYear*: | |
dateCreated*: | 1996-06-10X |
dateEstablished*: | 1997-01-01X |
Type: | |
Coordinate terms: | |
URI: | |
Labels and equivalent concepts: | Disintegriinit (fi) XDisintegriini (fi, replaced) Disintegriner (sv) |
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