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Transient Receptor Potential Channels
Hierarchy: | ∟ ∟ ∟ ∟ ∟ ∟ Transient Receptor Potential Channels 5 coordinate concepts4 subordinate concepts∟ ∟ ∟ ∟ ∟ ∟ Transient Receptor Potential Channels 5 coordinate concepts4 subordinate concepts∟ ∟ ∟ ∟ ∟ ∟ Transient Receptor Potential Channels 5 coordinate concepts4 subordinate concepts∟ ∟ ∟ ∟ ∟ ∟ Transient Receptor Potential Channels 5 coordinate concepts4 subordinate concepts∟ ∟ ∟ ∟ ∟ ∟ Transient Receptor Potential Channels 5 coordinate concepts4 subordinate conceptsX |
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Annotation: | note entry terms: TRP refers to transient receptor potential not TRYPTOPHAN
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History note: | |
historyNote*: | 2006
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publicMeSHNote*: | 2006
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Scope note: | A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN repeats are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or PHOSPHOLIPASE C.
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activeMeSHYear*: | |
dateCreated*: | 2005-06-30X |
dateEstablished*: | 2006-01-01X |
recordAuthorizer*: | sjnX |
recordMaintainer*: | ssbX |
recordOriginator*: | ssbX |
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Labels and equivalent concepts: | TRPC (fi) XTRP Membrane Proteins (en, replaced) TRP Cation Channels (en, replaced) |
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