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Cytochrome-B(5) Reductase
Hierarchy: | ∟ ∟ ∟ ∟ Cytochrome-B(5) Reductase 20 coordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ Cytochrome-B(5) Reductase 20 coordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ |
Broader terms: | |
Annotation: | /defic: consider also METHEMOGLOBINEMIA
X |
History note: | Cytochrome Reductases (1975-2003) | NADH, NADPH Oxidoreductases (1975-1990) | Oxidoreductases (1973-1974)X |
historyNote*: | 2004; use CYTOCHROME B(5) REDUCTASE (NM) 1980-2003
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publicMeSHNote*: | 2004; CYTOCHROME B(5)REDUCTASE was indexed under CYTOCHROME REDUCTASES 1975-2003 & under OXIDOREDUCTASES 1973-1974; for METHEMOGLOBIN REDUCTASE see METHEMOGLOBIN REDUCTASE 1991-2003, see NADH, NADPH OXIDOREDUCTASES 1975-1990
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Scope note: | A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.
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activeMeSHYear*: | |
dateCreated*: | 2003-07-09X |
dateEstablished*: | 2004-01-01X |
recordAuthorizer*: | sjnX |
recordMaintainer*: | AKEX |
recordOriginator*: | AKEX |
Type: | |
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URI: | |
Labels and equivalent concepts: | Sytokromi-B(5)-reduktaasi (fi) XCytokrom-B(5)-reduktas (sv) NADH-Ferrihemoglobin Reductase (en, replaced) NADH-Cytochrome B5 Reductase (en, replaced) NADH Methemoglobin Reductase (en, replaced) NADH Cytochrome B5 Reductase (en, replaced) |
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