ONKI3 | Medical Subject Headings

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Peptides ∟ Intercellular Signaling Peptides and Proteins ∟ Semaphorins 18 coordinate concepts 1 subordinate concept ∟ Semaphorin-3A ∟ Angiogenic Proteins \| ∟ Bone Morphogenetic Proteins \| ∟ Cytokines \| ∟ Endothelial Growth Factors \| ∟ Endothelins \| ∟ Ephrins \| ∟ Epidermal Growth Factor \| ∟ Fibroblast Growth Factors \| ∟ Hedgehog Proteins \| ∟ Interferons \| ∟ Kinins \| ∟ Nerve Growth Factors \| ∟ Parathyroid Hormone-Related Protein \| ∟ Platelet-Derived Growth Factor \| ∟ Somatomedins \| ∟ Transforming Growth Factors \| ∟ Tumor Necrosis Factors \| ∟ Wnt Proteins Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Intercellular Signaling Peptides and Proteins ∟ Semaphorins 18 coordinate concepts 1 subordinate concept ∟ Semaphorin-3A ∟ Angiogenic Proteins \| ∟ Bone Morphogenetic Proteins \| ∟ Cytokines \| ∟ Endothelial Growth Factors \| ∟ Endothelins \| ∟ Ephrins \| ∟ Epidermal Growth Factor \| ∟ Fibroblast Growth Factors \| ∟ Hedgehog Proteins \| ∟ Interferons \| ∟ Kinins \| ∟ Nerve Growth Factors \| ∟ Parathyroid Hormone-Related Protein \| ∟ Platelet-Derived Growth Factor \| ∟ Somatomedins \| ∟ Transforming Growth Factors \| ∟ Tumor Necrosis Factors \| ∟ Wnt Proteins Medical Subject Headings (MeSH) ∟ Biological Factors ∟ Intercellular Signaling Peptides and Proteins ∟ Semaphorins 18 coordinate concepts 1 subordinate concept ∟ Semaphorin-3A ∟ Angiogenic Proteins \| ∟ Bone Morphogenetic Proteins \| ∟ Cytokines \| ∟ Endothelial Growth Factors \| ∟ Endothelins \| ∟ Ephrins \| ∟ Epidermal Growth Factor \| ∟ Fibroblast Growth Factors \| ∟ Hedgehog Proteins \| ∟ Interferons \| ∟ Kinins \| ∟ Nerve Growth Factors \| ∟ Parathyroid Hormone-Related Protein \| ∟ Platelet-Derived Growth Factor \| ∟ Somatomedins \| ∟ Transforming Growth Factors \| ∟ Tumor Necrosis Factors \| ∟ Wnt Proteins X
Broader terms:	Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Peptides ∟ Intercellular Signaling Peptides and Proteins ∟ Semaphorins Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Intercellular Signaling Peptides and Proteins ∟ Semaphorins Medical Subject Headings (MeSH) ∟ Biological Factors ∟ Intercellular Signaling Peptides and Proteins ∟ Semaphorins Intercellular Signaling Peptides and Proteins > Peptides > Amino Acids, Peptides, and Proteins > Medical Subject Headings (MeSH) Intercellular Signaling Peptides and Proteins > Proteins > Amino Acids, Peptides, and Proteins > Medical Subject Headings (MeSH) Intercellular Signaling Peptides and Proteins > Biological Factors > Medical Subject Headings (MeSH) X
Narrower terms:	Semaphorin-3A X
historyNote*:	2003; for SEMA 1 & SEMAPHORIN-1 use SEMAPHORIN 1A, GRASSHOPPER (NM) 1994-2002 X
publicMeSHNote*:	2003; SEMA 1 & SEMAPHORIN-1 was indexed under CELL ADHESION MOLECULES, NEURONAL 1994-2002 X
Scope note:	A family of proteins that mediate axonal guidance. Semaphorins act as repulsive cues for neuronal GROWTH CONES and bind to receptors on their filopodia. At least 20 different molecules have been described and divided into eight classes based on domain organization and species of origin. Classes 1 and 2 are invertebrate, classes 3-7 are vertebrate, and class V are viral. Semaphorins may be secreted (classes 2, 3, and V), transmembrane (classes 1, 4, 5, and 6), or membrane-anchored (class 7). All semaphorins possess a common 500-amino acid extracellular domain which is critical for receptor binding and specificity, and is also found in plexins and scatter factor receptors. Their C termini are class-specific and may contain additional sequence motifs. X
activeMeSHYear*:	2007X
dateCreated*:	2002-07-03X
dateEstablished*:	2003-01-01X
dateRevised*:	2006-07-05X
recordAuthorizer*:	sjnX
recordMaintainer*:	jmpX
recordOriginator*:	MDJX
Type:	Concept X
Coordinate terms:	Angiogenic Proteins \| Bone Morphogenetic Proteins \| Cytokines \| Endothelial Growth Factors \| Endothelins \| Ephrins \| Epidermal Growth Factor \| Fibroblast Growth Factors \| Hedgehog Proteins \| Interferons \| Kinins \| Nerve Growth Factors \| Parathyroid Hormone-Related Protein \| Platelet-Derived Growth Factor \| Somatomedins \| Transforming Growth Factors \| Tumor Necrosis Factors \| Wnt Proteins X
URI:	X
Labels and equivalent concepts:	Semaforiinit (fi) Semaforiini (fi, replaced) Semaforiner (sv) Semaphorin-6 (en, replaced) Semaphorin-7 (en, replaced) Semaphorin-V (en, replaced) Semaphorin-5 (en, replaced) Semaphorin-4 (en, replaced) Semaphorin (en, replaced) Semaphorin-1 (en, replaced) Semaphorin-2 (en, replaced) Semaphorin-3 (en, replaced) Sema 1 (en, replaced) X
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