ONKI3 | Medical Subject Headings

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Membrane Proteins ∟ Receptors, Cell Surface ∟ Neuropilins 23 coordinate concepts 2 subordinate concepts ∟ Neuropilin-1 \| ∟ Neuropilin-2 ∟ Antigens, CD36 \| ∟ Asialoglycoprotein Receptor \| ∟ Autoreceptors \| ∟ Frizzled Receptors \| ∟ Receptor Protein-Tyrosine Kinases \| ∟ Receptors, Biogenic Amine \| ∟ Receptors, Collagen \| ∟ Receptors, Death Domain \| ∟ Receptors, Eicosanoid \| ∟ Receptors, G-Protein-Coupled \| ∟ Receptors, Guanylate Cyclase-Coupled \| ∟ Receptors, Immunologic \| ∟ Receptors, Lipoprotein \| ∟ Receptors, N-Acetylglucosamine \| ∟ Receptors, Neurotransmitter \| ∟ Receptors, Notch \| ∟ Receptors, Odorant \| ∟ Receptors, Peptide \| ∟ Receptors, Pheromone \| ∟ Receptors, Proteinase-Activated \| ∟ Receptors, Purinergic \| ∟ Receptors, Transferrin \| ∟ Receptors, Virus X
Broader terms:	Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Membrane Proteins ∟ Receptors, Cell Surface ∟ Neuropilins Receptors, Cell Surface > Membrane Proteins > Proteins > Amino Acids, Peptides, and Proteins > Medical Subject Headings (MeSH) X
Narrower terms:	Neuropilin-1 \| Neuropilin-2 X
History note:	Nerve Tissue Proteins (1998-2002)X
historyNote*:	2003; for NEUROPILIN use NEUROPILIN-1 (NM) 1998-2002 X
publicMeSHNote*:	2003; NEUROPILIN was indexed under NERVE TISSUE PROTEINS 1998-2002 X
Scope note:	Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance molecules during neural development and axonal outgrowth, and modulate VEGF-mediated angiogenesis. NEUROPILIN-1 and NEUROPILIN-2 differ in their binding specificities, and are distributed complementarily in regions of the developing nervous system. Neuropilins are receptors for secreted CLASS 3 SEMAPHORINS as well as for vascular endothelial growth factors, and may form hetero- or homodimers. They may also interact synergistically with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities and specificities. Neuropilin binding specificity is determined by CUB and coagulation-factor-like domains in the extracellular portion of the molecule, while a MAM domain is essential for SIGNAL TRANSDUCTION. X
activeMeSHYear*:	2006 \| 2007X
dateCreated*:	2002-07-03X
dateEstablished*:	2003-01-01X
dateRevised*:	2005-06-30X
recordAuthorizer*:	sjnX
recordMaintainer*:	jmpX
recordOriginator*:	MDJX
Type:	Concept X
Coordinate terms:	Antigens, CD36 \| Asialoglycoprotein Receptor \| Autoreceptors \| Frizzled Receptors \| Receptor Protein-Tyrosine Kinases \| Receptors, Biogenic Amine \| Receptors, Collagen \| Receptors, Death Domain \| Receptors, Eicosanoid \| Receptors, G-Protein-Coupled \| Receptors, Guanylate Cyclase-Coupled \| Receptors, Immunologic \| Receptors, Lipoprotein \| Receptors, N-Acetylglucosamine \| Receptors, Neurotransmitter \| Receptors, Notch \| Receptors, Odorant \| Receptors, Peptide \| Receptors, Pheromone \| Receptors, Proteinase-Activated \| Receptors, Purinergic \| Receptors, Transferrin \| Receptors, Virus X
URI:	X
Labels and equivalent concepts:	Neuropiliinit (fi) Neuropiliini (fi, replaced) Neuropiliner (sv) Neuropilin (en, replaced) X
Share:	X