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Integrin alpha Chains
Hierarchy: | ∟ ∟ ∟ ∟ ∟ ∟ ∟ Integrin alpha Chains 7 coordinate concepts11 subordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ |
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History note: | Integrins (1966-2002)X |
historyNote*: | 2003
X |
publicMeSHNote*: | 2003
X |
Scope note: | The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short (>50 AA) with the exception of INTEGRIN ALPHA4.
X |
activeMeSHYear*: | |
dateCreated*: | 2002-07-02X |
dateEstablished*: | 2003-01-01X |
dateRevised*: | 2005-07-13X |
recordAuthorizer*: | agsX |
recordMaintainer*: | agsX |
recordOriginator*: | MDJX |
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Labels and equivalent concepts: | Alfaintegriiniketjut (fi) XIntegrin alpha Subunits (en, replaced) alpha Integrins (en, replaced) Alfaintegriiniketju (la-FI, replaced) Alfa-integriiniketjut (la-FI, replaced) Alfa-integriiniketju (la-FI, replaced) |
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