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Sirtuins
Hierarchy: | ∟ ∟ ∟ ∟ ∟ Sirtuins 20 coordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ Sirtuins 20 coordinate conceptsX |
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Annotation: | note specific sirtuins in SCR
X |
History note: | Histone Deacetylase (2000-2002)X |
historyNote*: | 2003
X |
publicMeSHNote*: | 2003
X |
Scope note: | A homologous family of proteins that includes the NAD-dependent protein deacetylases which deacetylate proteins by catalyzing the formation of O-acetyl-ADP-ribose from the ADP-RIBOSE moiety (of NAD) and the acetyl group that is being removed from the protein. Sir2p, from Saccharomyces cerevisiae, is the founding member and the family includes other homologs (HSTs - homologs of Sir Two). Some HISTONE DEACETYLASES (the Sir2-like HDACs) belong to this family of proteins.
X |
activeMeSHYear*: | |
dateCreated*: | 2002-07-03X |
dateEstablished*: | 2003-01-01X |
dateRevised*: | 2003-07-09X |
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Labels and equivalent concepts: | Sirtuiinit (fi) XSirtuiini (fi, replaced) Sirtuiner (sv) Sir2-liknande proteiner (sv, replaced) Sir2-like Proteins (en, replaced) Sir2-like Deacetylases (en, replaced) Silent Mating Type Information Regulator 2-like Proteins (en, replaced) |
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