ONKI3 | Medical Subject Headings

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Peptides ∟ Intracellular Signaling Peptides and Proteins ∟ Apoptosis Regulatory Proteins ∟ Caspases 12 coordinate concepts 2 subordinate concepts ∟ Caspases, Effector \| ∟ Caspases, Initiator ∟ Apoptosis Inducing Factor \| ∟ CARD Signaling Adaptor Proteins \| ∟ Death Domain Receptor Signaling Adaptor Proteins \| ∟ Inhibitor of Apoptosis Proteins \| ∟ Proto-Oncogene Proteins c-bcl-2 \| ∟ Bromelains \| ∟ Calpain \| ∟ Cathepsin B \| ∟ Chymopapain \| ∟ D003546Q000037* \| ∟ Ficain \| ∟ Papain Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Intracellular Signaling Peptides and Proteins ∟ Apoptosis Regulatory Proteins ∟ Caspases 12 coordinate concepts 2 subordinate concepts ∟ Caspases, Effector \| ∟ Caspases, Initiator ∟ Apoptosis Inducing Factor \| ∟ CARD Signaling Adaptor Proteins \| ∟ Death Domain Receptor Signaling Adaptor Proteins \| ∟ Inhibitor of Apoptosis Proteins \| ∟ Proto-Oncogene Proteins c-bcl-2 \| ∟ Bromelains \| ∟ Calpain \| ∟ Cathepsin B \| ∟ Chymopapain \| ∟ D003546Q000037* \| ∟ Ficain \| ∟ Papain Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Hydrolases ∟ Peptide Hydrolases ∟ Endopeptidases ∟ Cysteine Endopeptidases ∟ Caspases 12 coordinate concepts 2 subordinate concepts ∟ Caspases, Effector \| ∟ Caspases, Initiator ∟ Apoptosis Inducing Factor \| ∟ CARD Signaling Adaptor Proteins \| ∟ Death Domain Receptor Signaling Adaptor Proteins \| ∟ Inhibitor of Apoptosis Proteins \| ∟ Proto-Oncogene Proteins c-bcl-2 \| ∟ Bromelains \| ∟ Calpain \| ∟ Cathepsin B \| ∟ Chymopapain \| ∟ D003546Q000037* \| ∟ Ficain \| ∟ Papain X
Broader terms:	Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Peptides ∟ Intracellular Signaling Peptides and Proteins ∟ Apoptosis Regulatory Proteins ∟ Caspases Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Intracellular Signaling Peptides and Proteins ∟ Apoptosis Regulatory Proteins ∟ Caspases Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Hydrolases ∟ Peptide Hydrolases ∟ Endopeptidases ∟ Cysteine Endopeptidases ∟ Caspases Apoptosis Regulatory Proteins > Intracellular Signaling Peptides and Proteins > Peptides > Amino Acids, Peptides, and Proteins > Medical Subject Headings (MeSH) Apoptosis Regulatory Proteins > Intracellular Signaling Peptides and Proteins > Proteins > Amino Acids, Peptides, and Proteins > Medical Subject Headings (MeSH) Cysteine Endopeptidases > Endopeptidases > Peptide Hydrolases > Hydrolases > Enzymes > Enzymes and Coenzymes > Medical Subject Headings (MeSH) X
Narrower terms:	Caspases, Effector \| Caspases, Initiator X
Annotation:	CASPASES, EFFECTOR and CASPASES, INITIATOR and specifics are available X
History note:	Cysteine Proteinases (1997-1998)X
historyNote*:	99 X
publicMeSHNote*:	99 X
Scope note:	A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur. X
activeMeSHYear*:	2007X
dateCreated*:	1998-06-10X
dateEstablished*:	1999-01-01X
dateRevised*:	2006-07-05X
recordAuthorizer*:	sjnX
recordMaintainer*:	jmpX
recordOriginator*:	ADPX
Related term:	Apoptosis X
Type:	Concept X
Coordinate terms:	Apoptosis Inducing Factor \| CARD Signaling Adaptor Proteins \| Death Domain Receptor Signaling Adaptor Proteins \| Inhibitor of Apoptosis Proteins \| Proto-Oncogene Proteins c-bcl-2 \| Bromelains \| Calpain \| Cathepsin B \| Chymopapain \| D003546Q000037* \| Ficain \| Papain X
URI:	X
Labels and equivalent concepts:	Kaspaasit (fi) Kaspaasi (fi, replaced) Kaspaser (sv) X
Share:	X