ONKI3 | Medical Subject Headings

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The way property values are displayed: value/row values side by side

The way concept relations are shown: separately in hierarchy

Tissue Inhibitor of Metalloproteinases

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Tissue Inhibitor of Metalloproteinases 98 coordinate concepts 3 subordinate concepts ∟ Tissue Inhibitor of Metalloproteinase-1 \| ∟ Tissue Inhibitor of Metalloproteinase-2 \| ∟ Tissue Inhibitor of Metalloproteinase-3 ∟ Albumins \| ∟ Algal Proteins \| ∟ Amphibian Proteins \| ∟ Amyloid \| ∟ Antifreeze Proteins \| ∟ Apoproteins \| ∟ Aprotinin \| ∟ Archaeal Proteins \| ∟ Armadillo Domain Proteins \| ∟ Avian Proteins \| ∟ Bacterial Proteins \| ∟ Blood Proteins \| ∟ Carrier Proteins \| ∟ Cell Cycle Proteins \| ∟ Cerebrospinal Fluid Proteins \| ∟ Colipases \| ∟ Contractile Proteins \| ∟ Cystatins \| ∟ Cytoskeletal Proteins \| ∟ D011506Q000096* \| ∟ D011506Q000097* \| ∟ D011506Q000134* \| ∟ D011506Q000172* \| ∟ D011506Q000652* \| ∟ Dental Enamel Proteins \| ∟ Dietary Proteins \| ∟ DNA-Binding Proteins \| ∟ Dynein ATPase \| ∟ Egg Proteins \| ∟ Epididymal Secretory Proteins \| ∟ Eye Proteins \| ∟ Fanconi Anemia Complementation Group Proteins \| ∟ Fetal Proteins \| ∟ Fish Proteins \| ∟ Flavoproteins \| ∟ Fungal Proteins \| ∟ Globulins \| ∟ Glycoproteins \| ∟ GTP-Binding Protein Regulators \| ∟ Heat-Shock Proteins \| ∟ Helminth Proteins \| ∟ Hemeproteins \| ∟ Immediate-Early Proteins \| ∟ Insect Proteins \| ∟ Intercellular Signaling Peptides and Proteins \| ∟ Intracellular Signaling Peptides and Proteins \| ∟ Iodoproteins \| ∟ Iron-Regulatory Proteins \| ∟ LDL-Receptor Related Proteins \| ∟ Lectins \| ∟ Lipoproteins \| ∟ Lithostathine \| ∟ Luminescent Proteins \| ∟ Membrane Proteins \| ∟ Metalloproteins \| ∟ Mitochondrial Proteins \| ∟ Molecular Chaperones \| ∟ Mutant Proteins \| ∟ Neoplasm Proteins \| ∟ Nerve Tissue Proteins \| ∟ Nuclear Proteins \| ∟ Nucleoproteins \| ∟ Oxidative Phosphorylation Coupling Factors \| ∟ Peptones \| ∟ Phosphoproteins \| ∟ Photoreceptors, Microbial \| ∟ Photosynthetic Reaction Center Complex Proteins \| ∟ Plant Proteins \| ∟ Polyproteins \| ∟ Pregnancy Proteins \| ∟ Prions \| ∟ Protein Hydrolysates \| ∟ Protein Isoforms \| ∟ Protein Precursors \| ∟ Protein Subunits \| ∟ Proteinase Inhibitory Proteins, Secretory \| ∟ Proteolipids \| ∟ Proteome \| ∟ Protozoan Proteins \| ∟ Pulmonary Surfactant-Associated Proteins \| ∟ Receptors, Cytoplasmic and Nuclear \| ∟ Receptors, Drug \| ∟ Recombinant Proteins \| ∟ Reptilian Proteins \| ∟ Ribosomal Proteins \| ∟ Salivary Proteins \| ∟ Scleroproteins \| ∟ Selenium-Binding Proteins \| ∟ Selenoproteins \| ∟ Seminal Plasma Proteins \| ∟ Serpins \| ∟ Silk \| ∟ Silver Proteins \| ∟ Thioredoxin \| ∟ Thymosin \| ∟ Transcription Factors \| ∟ Ubiquitins \| ∟ Viral Proteins X
Broader terms:	Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Tissue Inhibitor of Metalloproteinases Proteins > Amino Acids, Peptides, and Proteins > Medical Subject Headings (MeSH) X
Narrower terms:	Tissue Inhibitor of Metalloproteinase-1 \| Tissue Inhibitor of Metalloproteinase-2 \| Tissue Inhibitor of Metalloproteinase-3 X
Annotation:	a family of protease inhibitors; GEN or unspecified; prefer specifics; DF: TIMP X
History note:	Enzyme Inhibitors (1989-1997) \| Glycoproteins (1980-1990)X
historyNote*:	98; see TISSUE INHIBITOR OF METALLOPROTEINASES (NM) 1980-97 X
publicMeSHNote*:	98; COLLAGENASE INHIBITOR (now TISSUE INHIBITOR OF METALLOPROTEINASES) was indexed under GLYCOPROTEINS 1989-97 & ENZYME INHIBITORS 1980-90 X
Scope note:	A family of secreted proteins (TIMP-1; TIMP-2; and TIMP-3) that play a crucial role in regulating the activity of the secreted METALLOENDOPEPTIDASES; (COLLAGENASES; stromelysins; GELATINASES). Of the three characterized, only TIMP-1 and TIMP-2 appear to have related primary structures and inhibitory properties. They influence the activation of the prometalloproteinase and act to modulate proteolysis of extracellular matrix, notably during tissue remodeling and inflammatory processes. On certain cell types, they can exhibit growth factor-like activity, and they can inhibit the tumorigenic and metastatic phenotype in cancer cells. (Pharmacol Ther 1993;59:329-41) X
activeMeSHYear*:	2006 \| 2006A \| 2007X
dateCreated*:	1997-06-20X
dateEstablished*:	1998-01-01X
dateRevised*:	2005-07-20X
recordAuthorizer*:	agsX
recordMaintainer*:	agsX
recordOriginator*:	ADPX
Type:	Concept X
Coordinate terms:	Albumins \| Algal Proteins \| Amphibian Proteins \| Amyloid \| Antifreeze Proteins \| Apoproteins \| Aprotinin \| Archaeal Proteins \| Armadillo Domain Proteins \| Avian Proteins \| Bacterial Proteins \| Blood Proteins \| Carrier Proteins \| Cell Cycle Proteins \| Cerebrospinal Fluid Proteins \| Colipases \| Contractile Proteins \| Cystatins \| Cytoskeletal Proteins \| D011506Q000096* \| D011506Q000097* \| D011506Q000134* \| D011506Q000172* \| D011506Q000652* \| Dental Enamel Proteins \| Dietary Proteins \| DNA-Binding Proteins \| Dynein ATPase \| Egg Proteins \| Epididymal Secretory Proteins \| Eye Proteins \| Fanconi Anemia Complementation Group Proteins \| Fetal Proteins \| Fish Proteins \| Flavoproteins \| Fungal Proteins \| Globulins \| Glycoproteins \| GTP-Binding Protein Regulators \| Heat-Shock Proteins \| Helminth Proteins \| Hemeproteins \| Immediate-Early Proteins \| Insect Proteins \| Intercellular Signaling Peptides and Proteins \| Intracellular Signaling Peptides and Proteins \| Iodoproteins \| Iron-Regulatory Proteins \| LDL-Receptor Related Proteins \| Lectins \| Lipoproteins \| Lithostathine \| Luminescent Proteins \| Membrane Proteins \| Metalloproteins \| Mitochondrial Proteins \| Molecular Chaperones \| Mutant Proteins \| Neoplasm Proteins \| Nerve Tissue Proteins \| Nuclear Proteins \| Nucleoproteins \| Oxidative Phosphorylation Coupling Factors \| Peptones \| Phosphoproteins \| Photoreceptors, Microbial \| Photosynthetic Reaction Center Complex Proteins \| Plant Proteins \| Polyproteins \| Pregnancy Proteins \| Prions \| Protein Hydrolysates \| Protein Isoforms \| Protein Precursors \| Protein Subunits \| Proteinase Inhibitory Proteins, Secretory \| Proteolipids \| Proteome \| Protozoan Proteins \| Pulmonary Surfactant-Associated Proteins \| Receptors, Cytoplasmic and Nuclear \| Receptors, Drug \| Recombinant Proteins \| Reptilian Proteins \| Ribosomal Proteins \| Salivary Proteins \| Scleroproteins \| Selenium-Binding Proteins \| Selenoproteins \| Seminal Plasma Proteins \| Serpins \| Silk \| Silver Proteins \| Thioredoxin \| Thymosin \| Transcription Factors \| Ubiquitins \| Viral Proteins X
URI:	X
Labels and equivalent concepts:	TIMP (fi) Metalloproteinaasien kudosinhibiittori (fi, replaced) TIMP (en, replaced) X
Share:	X