ONKI3 | Medical Subject Headings

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Hydrolases ∟ Esterases ∟ Phosphoric Monoester Hydrolases ∟ Phosphoprotein Phosphatase ∟ Calcineurin 5 coordinate concepts ∟ Glycogen-Synthase-D Phosphatase \| ∟ Myosin-Light-Chain Phosphatase \| ∟ Phosphorylase Phosphatase \| ∟ Protein-Tyrosine-Phosphatase \| ∟ Pyruvate Dehydrogenase (Lipoamide)-Phosphatase X
Broader terms:	Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Hydrolases ∟ Esterases ∟ Phosphoric Monoester Hydrolases ∟ Phosphoprotein Phosphatase ∟ Calcineurin Phosphoprotein Phosphatase > Phosphoric Monoester Hydrolases > Esterases > Hydrolases > Enzymes > Enzymes and Coenzymes > Medical Subject Headings (MeSH) X
Annotation:	a calcium- & calmodulin-binding protein in the CNS; DF: note short X ref X
History note:	Calcium-Binding Proteins (1986-1997) \| Calmodulin-Binding Proteins (1986-1997) \| Phosphoprotein Phosphatase (1988-1997)X
historyNote*:	98; see CALCINEURIN (NM) 1987-97 X
publicMeSHNote*:	98; CALCINEURIN was indexed under PHOSPHOPROTEIN PHOSPHATASE 1988-97 & CALMODULIN-BINDING PROTEINS 1986-97; CALCINEURIN B (now CALCINEURIN) was indexed under CALCIUM-BINDING PROTEINS 1994-97 X
Scope note:	A calcium- and calmodulin-binding protein present in highest concentrations in the central nervous system. Calcineurin is composed of two subunits. A catalytic subunit, calcineurin A, and a regulatory subunit, calcineurin B, with molecular weights of about 60 kDa and 19 kDa, respectively. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including histones, myosin light chain, and the regulatory subunit of cAMP-dependent protein kinase. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes in T-lymphocytes that act by inhibiting T-cell activation. X
activeMeSHYear*:	2006 \| 2007X
dateCreated*:	1997-06-20X
dateEstablished*:	1998-01-01X
dateRevised*:	2005-06-30X
recordAuthorizer*:	sjnX
recordMaintainer*:	agsX
recordOriginator*:	ADPX
Type:	Concept X
Coordinate terms:	Glycogen-Synthase-D Phosphatase \| Myosin-Light-Chain Phosphatase \| Phosphorylase Phosphatase \| Protein-Tyrosine-Phosphatase \| Pyruvate Dehydrogenase (Lipoamide)-Phosphatase X
URI:	X
Labels and equivalent concepts:	Kalsineuriini (fi) Kalcineurin (sv) Protein Phosphatase-2B (en, replaced) Protein Phosphatase 2B (en, replaced) PP2B (en, replaced) X
Share:	X