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Thrombospondins
Hierarchy: | ∟ ∟ ∟ ∟ ∟ Thrombospondins 33 coordinate concepts1 subordinate concept∟ ∟ ∟ ∟ ∟ Thrombospondins 33 coordinate concepts1 subordinate concept∟ ∟ ∟ ∟ ∟ Thrombospondins 33 coordinate concepts1 subordinate conceptX |
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Annotation: | membrane glycoproteins; THROMBOSPONDIN 1 is also available
X |
History note: | Glycoproteins (1981-1989) | Membrane Glycoproteins (1989-1997) | Platelet Membrane Glycoproteins (1992-1993)X |
historyNote*: | 98; see THROMBOSPONDINS (NM) 1981-97
X |
publicMeSHNote*: | 98; THROMBOSPONDIN was indexed under MEMBRANE GLYCOPROTEINS 1989-97, PLATELET MEMBRANE GLYCOPROTEINS 1992-93, & GLYCOPROTEINS 1981-89
X |
Scope note: | A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, vascular smooth muscle growth, and tissue repair.
X |
activeMeSHYear*: | |
dateCreated*: | 1997-06-20X |
dateEstablished*: | 1998-01-01X |
dateRevised*: | 2005-06-30X |
recordAuthorizer*: | sjnX |
recordMaintainer*: | SYSTEMX |
recordOriginator*: | ADPX |
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Labels and equivalent concepts: | Trombospondiinit (fi) XTrombospondiini (fi, replaced) Thrombospondin (en, replaced) Thrombospondinum (la-FI, replaced) |
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