ONKI3 | Medical Subject Headings

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Protein S Deficiency

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Hemic and Lymphatic Diseases ∟ Hematologic Diseases ∟ Blood Coagulation Disorders ∟ Protein S Deficiency 17 coordinate concepts ∟ Agammaglobulinemia \| ∟ Antithrombin III Deficiency \| ∟ Dysgammaglobulinemia \| ∟ Hypergammaglobulinemia \| ∟ Hypoproteinemia \| ∟ Paraproteinemias \| ∟ Protein C Deficiency \| ∟ Blood Coagulation Disorders, Inherited \| ∟ Coagulation Protein Disorders \| ∟ Disseminated Intravascular Coagulation \| ∟ Platelet Storage Pool Deficiency \| ∟ Purpura \| ∟ Purpura, Thrombocytopenic \| ∟ Thrombocythemia, Hemorrhagic \| ∟ Vitamin K Deficiency \| ∟ Activated Protein C Resistance \| ∟ Purpura, Thrombotic Thrombocytopenic Medical Subject Headings (MeSH) ∟ Hemic and Lymphatic Diseases ∟ Hematologic Diseases ∟ Blood Protein Disorders ∟ Protein S Deficiency 17 coordinate concepts ∟ Agammaglobulinemia \| ∟ Antithrombin III Deficiency \| ∟ Dysgammaglobulinemia \| ∟ Hypergammaglobulinemia \| ∟ Hypoproteinemia \| ∟ Paraproteinemias \| ∟ Protein C Deficiency \| ∟ Blood Coagulation Disorders, Inherited \| ∟ Coagulation Protein Disorders \| ∟ Disseminated Intravascular Coagulation \| ∟ Platelet Storage Pool Deficiency \| ∟ Purpura \| ∟ Purpura, Thrombocytopenic \| ∟ Thrombocythemia, Hemorrhagic \| ∟ Vitamin K Deficiency \| ∟ Activated Protein C Resistance \| ∟ Purpura, Thrombotic Thrombocytopenic Medical Subject Headings (MeSH) ∟ Hemic and Lymphatic Diseases ∟ Hematologic Diseases ∟ Thrombophilia ∟ Protein S Deficiency 17 coordinate concepts ∟ Agammaglobulinemia \| ∟ Antithrombin III Deficiency \| ∟ Dysgammaglobulinemia \| ∟ Hypergammaglobulinemia \| ∟ Hypoproteinemia \| ∟ Paraproteinemias \| ∟ Protein C Deficiency \| ∟ Blood Coagulation Disorders, Inherited \| ∟ Coagulation Protein Disorders \| ∟ Disseminated Intravascular Coagulation \| ∟ Platelet Storage Pool Deficiency \| ∟ Purpura \| ∟ Purpura, Thrombocytopenic \| ∟ Thrombocythemia, Hemorrhagic \| ∟ Vitamin K Deficiency \| ∟ Activated Protein C Resistance \| ∟ Purpura, Thrombotic Thrombocytopenic X
Broader terms:	Medical Subject Headings (MeSH) ∟ Hemic and Lymphatic Diseases ∟ Hematologic Diseases ∟ Blood Coagulation Disorders ∟ Protein S Deficiency Medical Subject Headings (MeSH) ∟ Hemic and Lymphatic Diseases ∟ Hematologic Diseases ∟ Blood Protein Disorders ∟ Protein S Deficiency Medical Subject Headings (MeSH) ∟ Hemic and Lymphatic Diseases ∟ Hematologic Diseases ∟ Thrombophilia ∟ Protein S Deficiency Blood Coagulation Disorders > Hematologic Diseases > Hemic and Lymphatic Diseases > Medical Subject Headings (MeSH) Blood Protein Disorders > Hematologic Diseases > Hemic and Lymphatic Diseases > Medical Subject Headings (MeSH) Thrombophilia > Hematologic Diseases > Hemic and Lymphatic Diseases > Medical Subject Headings (MeSH) X
Annotation:	a blood protein disord causing thromboses; DF: PROTEIN S DEFIC X
History note:	Glycoproteins/deficiency (1984-1992) \| Protein S/deficiency (1993-1994)X
historyNote*:	95 X
publicMeSHNote*:	95 X
Scope note:	An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523) X
activeMeSHYear*:	1999 \| 2000 \| 2001 \| 2002 \| 2003 \| 2004 \| 2005 \| 2006 \| 2007X
dateCreated*:	1994-04-16X
dateEstablished*:	1995-01-01X
dateRevised*:	1998-06-10X
recordAuthorizer*:	SJNX
recordMaintainer*:	NNSX
recordOriginator*:	TGCX
Type:	Concept X
Coordinate terms:	Agammaglobulinemia \| Antithrombin III Deficiency \| Dysgammaglobulinemia \| Hypergammaglobulinemia \| Hypoproteinemia \| Paraproteinemias \| Protein C Deficiency \| Blood Coagulation Disorders, Inherited \| Coagulation Protein Disorders \| Disseminated Intravascular Coagulation \| Platelet Storage Pool Deficiency \| Purpura \| Purpura, Thrombocytopenic \| Thrombocythemia, Hemorrhagic \| Vitamin K Deficiency \| Activated Protein C Resistance \| Purpura, Thrombotic Thrombocytopenic X
URI:	X
Labels and equivalent concepts:	Proteiini S:n puutos (fi) Proteiinin S puutos (fi, replaced) Proteiinin S puute (fi, replaced) Proteiini S:n puute (fi, replaced) Protein S-brist (sv) Deficiency, Protein S (en, replaced) X
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