ONKI3 | Medical Subject Headings

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Carrier Proteins ∟ Membrane Transport Proteins ∟ ATP-Binding Cassette Transporters ∟ P-Glycoproteins 2 coordinate concepts 1 subordinate concept ∟ P-Glycoprotein ∟ Multidrug Resistance-Associated Proteins \| ∟ P-Glycoprotein Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Carrier Proteins ∟ Membrane Transport Proteins ∟ Ion Pumps ∟ Anion Transport Proteins ∟ Organic Anion Transporters ∟ Organic Anion Transporters, ATP-Dependent ∟ P-Glycoproteins 2 coordinate concepts 1 subordinate concept ∟ P-Glycoprotein ∟ Multidrug Resistance-Associated Proteins \| ∟ P-Glycoprotein Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Glycoproteins ∟ Membrane Glycoproteins ∟ ATP-Binding Cassette Transporters ∟ P-Glycoproteins 2 coordinate concepts 1 subordinate concept ∟ P-Glycoprotein ∟ Multidrug Resistance-Associated Proteins \| ∟ P-Glycoprotein Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Membrane Proteins ∟ Membrane Glycoproteins ∟ ATP-Binding Cassette Transporters ∟ P-Glycoproteins 2 coordinate concepts 1 subordinate concept ∟ P-Glycoprotein ∟ Multidrug Resistance-Associated Proteins \| ∟ P-Glycoprotein Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Membrane Proteins ∟ Membrane Transport Proteins ∟ ATP-Binding Cassette Transporters ∟ P-Glycoproteins 2 coordinate concepts 1 subordinate concept ∟ P-Glycoprotein ∟ Multidrug Resistance-Associated Proteins \| ∟ P-Glycoprotein Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Membrane Proteins ∟ Membrane Transport Proteins ∟ Ion Pumps ∟ Anion Transport Proteins ∟ Organic Anion Transporters ∟ Organic Anion Transporters, ATP-Dependent ∟ P-Glycoproteins 2 coordinate concepts 1 subordinate concept ∟ P-Glycoprotein ∟ Multidrug Resistance-Associated Proteins \| ∟ P-Glycoprotein Medical Subject Headings (MeSH) ∟ Carbohydrates ∟ Glycoconjugates ∟ Glycoproteins ∟ Membrane Glycoproteins ∟ ATP-Binding Cassette Transporters ∟ P-Glycoproteins 2 coordinate concepts 1 subordinate concept ∟ P-Glycoprotein ∟ Multidrug Resistance-Associated Proteins \| ∟ P-Glycoprotein X
Broader terms:	Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Carrier Proteins ∟ Membrane Transport Proteins ∟ ATP-Binding Cassette Transporters ∟ P-Glycoproteins Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Carrier Proteins ∟ Membrane Transport Proteins ∟ Ion Pumps ∟ Anion Transport Proteins ∟ Organic Anion Transporters ∟ Organic Anion Transporters, ATP-Dependent ∟ P-Glycoproteins Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Glycoproteins ∟ Membrane Glycoproteins ∟ ATP-Binding Cassette Transporters ∟ P-Glycoproteins Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Membrane Proteins ∟ Membrane Glycoproteins ∟ ATP-Binding Cassette Transporters ∟ P-Glycoproteins Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Membrane Proteins ∟ Membrane Transport Proteins ∟ ATP-Binding Cassette Transporters ∟ P-Glycoproteins Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Membrane Proteins ∟ Membrane Transport Proteins ∟ Ion Pumps ∟ Anion Transport Proteins ∟ Organic Anion Transporters ∟ Organic Anion Transporters, ATP-Dependent ∟ P-Glycoproteins Medical Subject Headings (MeSH) ∟ Carbohydrates ∟ Glycoconjugates ∟ Glycoproteins ∟ Membrane Glycoproteins ∟ ATP-Binding Cassette Transporters ∟ P-Glycoproteins ATP-Binding Cassette Transporters > Membrane Transport Proteins > Carrier Proteins > Proteins > Amino Acids, Peptides, and Proteins > Medical Subject Headings (MeSH) Organic Anion Transporters, ATP-Dependent > Organic Anion Transporters > Anion Transport Proteins > Ion Pumps > Membrane Transport Proteins > Carrier Proteins > Proteins > Amino Acids, Peptides, and Proteins > Medical Subject Headings (MeSH) ATP-Binding Cassette Transporters > Membrane Glycoproteins > Glycoproteins > Proteins > Amino Acids, Peptides, and Proteins > Medical Subject Headings (MeSH) ATP-Binding Cassette Transporters > Membrane Glycoproteins > Membrane Proteins > Proteins > Amino Acids, Peptides, and Proteins > Medical Subject Headings (MeSH) ATP-Binding Cassette Transporters > Membrane Transport Proteins > Membrane Proteins > Proteins > Amino Acids, Peptides, and Proteins > Medical Subject Headings (MeSH) Organic Anion Transporters, ATP-Dependent > Organic Anion Transporters > Anion Transport Proteins > Ion Pumps > Membrane Transport Proteins > Membrane Proteins > Proteins > Amino Acids, Peptides, and Proteins > Medical Subject Headings (MeSH) ATP-Binding Cassette Transporters > Membrane Glycoproteins > Glycoproteins > Glycoconjugates > Carbohydrates > Medical Subject Headings (MeSH) X
Narrower terms:	P-Glycoprotein X
Annotation:	P-GLYCOPROTEIN is also available; P stands for "permeability" X
History note:	Glycoproteins (1980-1987) \| Membrane Glycoproteins (1989-1994) \| Membrane Proteins (1980-1988)X
historyNote*:	99; use P-GLYCOPROTEIN 1995-98 X
publicMeSHNote*:	99; see P-GLYCOPROTEIN 1995-98; P-GLYCOPROTEIN was indexed under CARRIER PROTEINS & MEMBRANE GLYCOPROTEINS 1980-94, GLYCOPROTEINS 1980-87, and MEMBRANE PROTEINS 1980-82 X
Scope note:	A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to P-GLYCOPROTEIN. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology. X
activeMeSHYear*:	2006 \| 2007X
dateCreated*:	1994-01-25X
dateEstablished*:	1995-01-01X
dateRevised*:	2005-06-30X
recordAuthorizer*:	sjnX
recordMaintainer*:	jmpX
recordOriginator*:	AGSX
Related term:	Drug Resistance, Multiple \| Genes, MDR \| Multidrug Resistance-Associated Proteins \| Rhodamine 123 X
Type:	Concept X
Coordinate terms:	Multidrug Resistance-Associated Proteins \| P-Glycoprotein X
URI:	X
Labels and equivalent concepts:	P-glykoproteiinit (fi) P-glykoproteiner (sv) Multidrug Resistance Proteins (en, replaced) ATP-Binding Cassette, Sub-Family B Proteins (en, replaced) X
Share:	X