ONKI3 | Medical Subject Headings

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Animals ∟ Animal Population Groups ∟ Organisms, Genetically Modified ∟ Animals, Genetically Modified ∟ Mice, Transgenic ∟ Mice, Knockout 8 coordinate concepts ∟ Mice, Biozzi \| ∟ Mice, Inbred mdx \| ∟ Mice, Jimpy \| ∟ Mice, Neurologic Mutants \| ∟ Mice, Nude \| ∟ Mice, Obese \| ∟ Mice, Quaking \| ∟ Mice, SCID Medical Subject Headings (MeSH) ∟ Animals ∟ Chordata ∟ Vertebrates ∟ Mammals ∟ Rodentia ∟ Muridae ∟ Murinae ∟ Mice ∟ Mice, Mutant Strains ∟ Mice, Knockout 8 coordinate concepts ∟ Mice, Biozzi \| ∟ Mice, Inbred mdx \| ∟ Mice, Jimpy \| ∟ Mice, Neurologic Mutants \| ∟ Mice, Nude \| ∟ Mice, Obese \| ∟ Mice, Quaking \| ∟ Mice, SCID Medical Subject Headings (MeSH) ∟ Animals ∟ Chordata ∟ Vertebrates ∟ Mammals ∟ Rodentia ∟ Muridae ∟ Murinae ∟ Mice ∟ Mice, Transgenic ∟ Mice, Knockout 8 coordinate concepts ∟ Mice, Biozzi \| ∟ Mice, Inbred mdx \| ∟ Mice, Jimpy \| ∟ Mice, Neurologic Mutants \| ∟ Mice, Nude \| ∟ Mice, Obese \| ∟ Mice, Quaking \| ∟ Mice, SCID Medical Subject Headings (MeSH) ∟ Plants ∟ Organisms, Genetically Modified ∟ Animals, Genetically Modified ∟ Mice, Transgenic ∟ Mice, Knockout 8 coordinate concepts ∟ Mice, Biozzi \| ∟ Mice, Inbred mdx \| ∟ Mice, Jimpy \| ∟ Mice, Neurologic Mutants \| ∟ Mice, Nude \| ∟ Mice, Obese \| ∟ Mice, Quaking \| ∟ Mice, SCID X
Broader terms:	Medical Subject Headings (MeSH) ∟ Animals ∟ Animal Population Groups ∟ Organisms, Genetically Modified ∟ Animals, Genetically Modified ∟ Mice, Transgenic ∟ Mice, Knockout Medical Subject Headings (MeSH) ∟ Animals ∟ Chordata ∟ Vertebrates ∟ Mammals ∟ Rodentia ∟ Muridae ∟ Murinae ∟ Mice ∟ Mice, Mutant Strains ∟ Mice, Knockout Medical Subject Headings (MeSH) ∟ Animals ∟ Chordata ∟ Vertebrates ∟ Mammals ∟ Rodentia ∟ Muridae ∟ Murinae ∟ Mice ∟ Mice, Transgenic ∟ Mice, Knockout Medical Subject Headings (MeSH) ∟ Plants ∟ Organisms, Genetically Modified ∟ Animals, Genetically Modified ∟ Mice, Transgenic ∟ Mice, Knockout Mice, Transgenic > Animals, Genetically Modified > Organisms, Genetically Modified > Animal Population Groups > Animals > Medical Subject Headings (MeSH) Mice, Mutant Strains > Mice > Murinae > Muridae > Rodentia > Mammals > Vertebrates > Chordata > Animals > Medical Subject Headings (MeSH) Mice, Transgenic > Mice > Murinae > Muridae > Rodentia > Mammals > Vertebrates > Chordata > Animals > Medical Subject Headings (MeSH) Mice, Transgenic > Animals, Genetically Modified > Organisms, Genetically Modified > Plants > Medical Subject Headings (MeSH) X
Annotation:	NIM no qualif when exper animal; do not forget also to check MICE X
History note:	Mice (1992-1993)X
historyNote*:	94 X
publicMeSHNote*:	94 X
Scope note:	Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes. X
activeMeSHYear*:	2006 \| 2007X
dateCreated*:	1993-06-03X
dateEstablished*:	1994-01-01X
dateRevised*:	2005-06-30X
recordAuthorizer*:	sjnX
recordMaintainer*:	agsX
recordOriginator*:	PXPX
Type:	Concept X
Coordinate terms:	Mice, Biozzi \| Mice, Inbred mdx \| Mice, Jimpy \| Mice, Neurologic Mutants \| Mice, Nude \| Mice, Obese \| Mice, Quaking \| Mice, SCID X
URI:	X
Labels and equivalent concepts:	Poistogeeniset hiiret (fi) Poistogeeninen hiiri (fi, replaced) Möss, knockout (sv) Knockoutmöss (sv, replaced) Mouse, Knockout (en, replaced) Mice, Knock-out (en, replaced) Knockout Mice (en, replaced) X
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