ONKI3 | Medical Subject Headings

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The way property values are displayed: value/row values side by side

The way concept relations are shown: separately in hierarchy

Neurofibrillary Tangles

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Cells ∟ Cellular Structures ∟ Intracellular Space ∟ Cytoplasm ∟ Cytoplasmic Structures ∟ Cytoskeleton ∟ Neurofibrils ∟ Neurofibrillary Tangles Medical Subject Headings (MeSH) ∟ Cells ∟ Neurons ∟ Neurofibrils ∟ Neurofibrillary Tangles Medical Subject Headings (MeSH) ∟ Nervous System ∟ Neurons ∟ Neurofibrils ∟ Neurofibrillary Tangles X
Broader terms:	Medical Subject Headings (MeSH) ∟ Cells ∟ Cellular Structures ∟ Intracellular Space ∟ Cytoplasm ∟ Cytoplasmic Structures ∟ Cytoskeleton ∟ Neurofibrils ∟ Neurofibrillary Tangles Medical Subject Headings (MeSH) ∟ Cells ∟ Neurons ∟ Neurofibrils ∟ Neurofibrillary Tangles Medical Subject Headings (MeSH) ∟ Nervous System ∟ Neurons ∟ Neurofibrils ∟ Neurofibrillary Tangles Neurofibrils > Cytoskeleton > Cytoplasmic Structures > Cytoplasm > Intracellular Space > Cellular Structures > Cells > Medical Subject Headings (MeSH) Neurofibrils > Neurons > Cells > Medical Subject Headings (MeSH) Neurofibrils > Neurons > Nervous System > Medical Subject Headings (MeSH) X
Annotation:	"one of the hallmarks of Alzheimer disease"; A 11 qualif except /cytol; /genet permitted X
History note:	Neurofibrils (1968-1991)X
historyNote*:	92 X
publicMeSHNote*:	92 X
Scope note:	Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: (1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of Alzheimer disease. X
activeMeSHYear*:	2004 \| 2005 \| 2006 \| 2007X
dateCreated*:	1991-05-02X
dateEstablished*:	1992-01-01X
dateRevised*:	2003-07-09X
recordAuthorizer*:	sjnX
recordMaintainer*:	nnsX
recordOriginator*:	MXRX
Related term:	Neurofilament Proteins \| Tauopathies X
Type:	Concept X
URI:	X
Labels and equivalent concepts:	Neurofibrillisotkut (fi) Neurofibrillnystan (sv) X
Share:	X