ONKI3 | Medical Subject Headings

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Biological Factors ∟ Toxins, Biological ∟ Mycotoxins ∟ Aflatoxins ∟ Aflatoxin M1 1 coordinate concept ∟ Aflatoxin B1 Medical Subject Headings (MeSH) ∟ Heterocyclic Compounds ∟ Heterocyclic Compounds, 1-Ring ∟ Pyrans ∟ Benzopyrans ∟ Aflatoxins ∟ Aflatoxin M1 1 coordinate concept ∟ Aflatoxin B1 Medical Subject Headings (MeSH) ∟ Heterocyclic Compounds ∟ Heterocyclic Compounds, 2-Ring ∟ Benzopyrans ∟ Aflatoxins ∟ Aflatoxin M1 1 coordinate concept ∟ Aflatoxin B1 Medical Subject Headings (MeSH) ∟ Heterocyclic Compounds ∟ Pyrans ∟ Benzopyrans ∟ Aflatoxins ∟ Aflatoxin M1 1 coordinate concept ∟ Aflatoxin B1 X
Broader terms:	Medical Subject Headings (MeSH) ∟ Biological Factors ∟ Toxins, Biological ∟ Mycotoxins ∟ Aflatoxins ∟ Aflatoxin M1 Medical Subject Headings (MeSH) ∟ Heterocyclic Compounds ∟ Heterocyclic Compounds, 1-Ring ∟ Pyrans ∟ Benzopyrans ∟ Aflatoxins ∟ Aflatoxin M1 Medical Subject Headings (MeSH) ∟ Heterocyclic Compounds ∟ Heterocyclic Compounds, 2-Ring ∟ Benzopyrans ∟ Aflatoxins ∟ Aflatoxin M1 Medical Subject Headings (MeSH) ∟ Heterocyclic Compounds ∟ Pyrans ∟ Benzopyrans ∟ Aflatoxins ∟ Aflatoxin M1 Aflatoxins > Mycotoxins > Toxins, Biological > Biological Factors > Medical Subject Headings (MeSH) Aflatoxins > Benzopyrans > Pyrans > Heterocyclic Compounds, 1-Ring > Heterocyclic Compounds > Medical Subject Headings (MeSH) Aflatoxins > Benzopyrans > Heterocyclic Compounds, 2-Ring > Heterocyclic Compounds > Medical Subject Headings (MeSH) Aflatoxins > Benzopyrans > Pyrans > Heterocyclic Compounds > Medical Subject Headings (MeSH) X
Annotation:	/antag permitted but consider also ANTITOXINS; DF: AFM1 X
History note:	Aflatoxins (1969-1991)X
historyNote*:	92; was AFLATOXIN (NM) 1980-91 X
onlineNote*:	use AFLATOXIN M1 (NM) to search AFLATOXIN M1 1979-91 X
publicMeSHNote*:	92; AFLATOXIN M1 was indexed under AFLATOXINS 1980-91 X
Scope note:	A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969). X
activeMeSHYear*:	2006 \| 2007X
dateCreated*:	1991-01-25X
dateEstablished*:	1992-01-01X
dateRevised*:	2005-06-30X
recordAuthorizer*:	sjnX
recordMaintainer*:	ssbX
recordOriginator*:	RLSX
Type:	Concept X
Coordinate terms:	Aflatoxin B1 X
URI:	X
Labels and equivalent concepts:	Aflatoksiini M1 (fi) 4-Hydroxyaflatoxin B1 (en, replaced) X
Share:	X