ONKI3 | Medical Subject Headings

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Gangliosidosis, GM1

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Metabolism, Inborn Errors ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidosis, GM1 2 coordinate concepts ∟ Gangliosidoses, GM2 \| ∟ Sandhoff Disease Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Metabolism, Inborn Errors ∟ Lipid Metabolism, Inborn Errors ∟ Lipidoses ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidosis, GM1 2 coordinate concepts ∟ Gangliosidoses, GM2 \| ∟ Sandhoff Disease Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Metabolism, Inborn Errors ∟ Lysosomal Storage Diseases ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidosis, GM1 2 coordinate concepts ∟ Gangliosidoses, GM2 \| ∟ Sandhoff Disease Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Central Nervous System Diseases ∟ Brain Diseases ∟ Brain Diseases, Metabolic ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidosis, GM1 2 coordinate concepts ∟ Gangliosidoses, GM2 \| ∟ Sandhoff Disease Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Brain Diseases, Metabolic ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidosis, GM1 2 coordinate concepts ∟ Gangliosidoses, GM2 \| ∟ Sandhoff Disease Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Lipid Metabolism Disorders ∟ Lipidoses ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidosis, GM1 2 coordinate concepts ∟ Gangliosidoses, GM2 \| ∟ Sandhoff Disease Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Metabolism, Inborn Errors ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidosis, GM1 2 coordinate concepts ∟ Gangliosidoses, GM2 \| ∟ Sandhoff Disease Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Metabolism, Inborn Errors ∟ Lipid Metabolism, Inborn Errors ∟ Lipidoses ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidosis, GM1 2 coordinate concepts ∟ Gangliosidoses, GM2 \| ∟ Sandhoff Disease Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Metabolism, Inborn Errors ∟ Lysosomal Storage Diseases ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidosis, GM1 2 coordinate concepts ∟ Gangliosidoses, GM2 \| ∟ Sandhoff Disease X
Broader terms:	Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Metabolism, Inborn Errors ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidosis, GM1 Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Metabolism, Inborn Errors ∟ Lipid Metabolism, Inborn Errors ∟ Lipidoses ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidosis, GM1 Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Metabolism, Inborn Errors ∟ Lysosomal Storage Diseases ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidosis, GM1 Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Central Nervous System Diseases ∟ Brain Diseases ∟ Brain Diseases, Metabolic ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidosis, GM1 Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Brain Diseases, Metabolic ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidosis, GM1 Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Lipid Metabolism Disorders ∟ Lipidoses ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidosis, GM1 Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Metabolism, Inborn Errors ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidosis, GM1 Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Metabolism, Inborn Errors ∟ Lipid Metabolism, Inborn Errors ∟ Lipidoses ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidosis, GM1 Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Metabolism, Inborn Errors ∟ Lysosomal Storage Diseases ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Gangliosidoses ∟ Gangliosidosis, GM1 Gangliosidoses > Sphingolipidoses > Lysosomal Storage Diseases, Nervous System > Brain Diseases, Metabolic, Inborn > Metabolism, Inborn Errors > Genetic Diseases, Inborn > Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Medical Subject Headings (MeSH) Gangliosidoses > Sphingolipidoses > Lipidoses > Lipid Metabolism, Inborn Errors > Metabolism, Inborn Errors > Genetic Diseases, Inborn > Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Medical Subject Headings (MeSH) Gangliosidoses > Sphingolipidoses > Lysosomal Storage Diseases, Nervous System > Lysosomal Storage Diseases > Metabolism, Inborn Errors > Genetic Diseases, Inborn > Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Medical Subject Headings (MeSH) Gangliosidoses > Sphingolipidoses > Lysosomal Storage Diseases, Nervous System > Brain Diseases, Metabolic, Inborn > Brain Diseases, Metabolic > Brain Diseases > Central Nervous System Diseases > Nervous System Diseases > Medical Subject Headings (MeSH) Gangliosidoses > Sphingolipidoses > Lysosomal Storage Diseases, Nervous System > Brain Diseases, Metabolic, Inborn > Brain Diseases, Metabolic > Metabolic Diseases > Nutritional and Metabolic Diseases > Medical Subject Headings (MeSH) Gangliosidoses > Sphingolipidoses > Lipidoses > Lipid Metabolism Disorders > Metabolic Diseases > Nutritional and Metabolic Diseases > Medical Subject Headings (MeSH) Gangliosidoses > Sphingolipidoses > Lysosomal Storage Diseases, Nervous System > Brain Diseases, Metabolic, Inborn > Metabolism, Inborn Errors > Metabolic Diseases > Nutritional and Metabolic Diseases > Medical Subject Headings (MeSH) Gangliosidoses > Sphingolipidoses > Lipidoses > Lipid Metabolism, Inborn Errors > Metabolism, Inborn Errors > Metabolic Diseases > Nutritional and Metabolic Diseases > Medical Subject Headings (MeSH) Gangliosidoses > Sphingolipidoses > Lysosomal Storage Diseases, Nervous System > Lysosomal Storage Diseases > Metabolism, Inborn Errors > Metabolic Diseases > Nutritional and Metabolic Diseases > Medical Subject Headings (MeSH) X
History note:	Gangliosidoses (1976-1991) \| Lipoidosis (1966-1975) \| Metabolism, Inborn Errors (1966-1975)X
historyNote*:	2007(1992) X
publicMeSHNote*:	2007; see GANGIOSIDOSIS GM1 2000-2006, see GANGLIOSIDOSIS G(M1) 1992-1999 X
Scope note:	An autosomal recessive neurodegenerative disorder caused by the absence or deficiency of BETA-GALACTOSIDASE. It is characterized by intralysosomal accumulation of G(M1) GANGLIOSIDE and oligosaccharides, primarily in neurons of the central nervous system. The infantile form is characterized by MUSCLE HYPOTONIA, poor psychomotor development, HIRSUTISM, hepatosplenomegaly, and facial abnormalities. The juvenile form features HYPERACUSIS; SEIZURES; and psychomotor retardation. The adult form features progressive DEMENTIA; ATAXIA; and MUSCLE SPASTICITY. (From Menkes, Textbook of Child Neurology, 5th ed, pp96-7) X
activeMeSHYear*:	2007X
dateCreated*:	1991-06-21X
dateEstablished*:	1992-01-01X
dateRevised*:	2006-07-05X
recordAuthorizer*:	sjnX
recordMaintainer*:	lktX
recordOriginator*:	AGSX
Related term:	beta-Galactosidase X
Type:	Concept X
Coordinate terms:	Gangliosidoses, GM2 \| Sandhoff Disease X
URI:	X
Labels and equivalent concepts:	Gangliosidoosi, GM1 (fi) GM1-gangliosidoosi (fi, replaced) GM1-gangliosidoosit (fi, replaced) Generalized Gangliosidosis (en, replaced) Gangliosidosis GM1, Type 3 (en, replaced) GM1 Gangliosidosis (en, replaced) Gangliosidosis GM1, Type 2 (en, replaced) Gangliosidosis GM1, Type 1 (en, replaced) Gangliosidosis G(M1) (en, replaced) G(M1) Gangliosidosis (en, replaced) Gangliosidosis GM1 (en, replaced) Gangliosidosis GM1, Adult (en, replaced) Gangliosidosis GM1, Juvenile (en, replaced) Gangliosidosis GM1, Infantile (en, replaced) Beta-Galactosidase-1 Deficiency Disease (en, replaced) Gangliosidosis GM1 (la-FI, replaced) X
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