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Zalcitabine
Hierarchy: | ∟ ∟ ∟ ∟ ∟ ∟ Zalcitabine 5 coordinate concepts1 subordinate concept∟ ∟ ∟ ∟ ∟ ∟ Zalcitabine 5 coordinate concepts1 subordinate concept∟ ∟ ∟ ∟ ∟ ∟ ∟ Zalcitabine 5 coordinate concepts1 subordinate concept∟ ∟ ∟ ∟ ∟ ∟ ∟ Zalcitabine 5 coordinate concepts1 subordinate concept∟ ∟ ∟ ∟ ∟ ∟ ∟ Zalcitabine 5 coordinate concepts1 subordinate concept∟ ∟ ∟ ∟ ∟ Zalcitabine 5 coordinate concepts1 subordinate concept∟ ∟ ∟ ∟ ∟ Zalcitabine 5 coordinate concepts1 subordinate concept∟ ∟ ∟ ∟ ∟ ∟ Zalcitabine 5 coordinate concepts1 subordinate concept∟ ∟ ∟ ∟ ∟ ∟ Zalcitabine 5 coordinate concepts1 subordinate conceptX |
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historyNote*: | 94; was DIDEOXYCYTIDINE 1990-93
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onlineNote*: | use ZALCITABINE to search DIDEOXYCYTIDINE 1990-93
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publicMeSHNote*: | 94; was DIDEOXYCYTIDINE 1990-93
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Scope note: | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
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activeMeSHYear*: | 2007X |
dateCreated*: | 1989-07-14X |
dateEstablished*: | 1990-01-01X |
dateRevised*: | 2006-07-05X |
recordAuthorizer*: | sjnX |
recordMaintainer*: | ssbX |
recordOriginator*: | AGSX |
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Labels and equivalent concepts: | Tsalsitabiini (fi) XZalcitabin (sv) Dideoxicytidin (sv, replaced) Hivid (sv, replaced) Roche Brand of Zalcitabine (en, replaced) Hoffman-La Roche Brand of Zalcitabine (en, replaced) HIVID Roche (en, replaced) ddC (Antiviral) (en, replaced) Dideoxycytidine (en, replaced) 2',3'-Dideoxycytidine (en, replaced) |
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