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Gene Therapy
Hierarchy: | ∟ ∟ ∟ ∟ Gene Therapy 12 coordinate concepts1 subordinate concept∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ Gene Therapy 12 coordinate concepts1 subordinate concept∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ |
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History note: | Genetic Intervention (1973-1988)X |
historyNote*: | 89
X |
publicMeSHNote*: | 89
X |
Scope note: | The introduction of new genes into cells for the purpose of treating disease by restoring or adding gene expression. Techniques include insertion of retroviral vectors, transfection, homologous recombination, and injection of new genes into the nuclei of single cell embryos. The entire gene therapy process may consist of multiple steps. The new genes may be introduced into proliferating cells in vivo (e.g., bone marrow) or in vitro (e.g., fibroblast cultures) and the modified cells transferred to the site where the gene expression is required. Gene therapy may be particularly useful for treating enzyme deficiency diseases, hemoglobinopathies, and leukemias and may also prove useful in restoring drug sensitivity, particularly for leukemia.
X |
activeMeSHYear*: | 2007X |
dateCreated*: | 1988-05-31X |
dateEstablished*: | 1989-01-01X |
dateRevised*: | 2006-07-05X |
recordAuthorizer*: | sjnX |
recordMaintainer*: | nnsX |
recordOriginator*: | EJBX |
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Labels and equivalent concepts: | Geenihoito (fi) XGeeniterapia (fi, replaced) Genterapi (sv) Therapy, Somatic Gene (en, replaced) Therapy, Gene (en, replaced) Therapy, DNA (en, replaced) Somatic Gene Therapy (en, replaced) DNA Therapy (en, replaced) |
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