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The way concept relations are shown:
The way concept relations are shown:
Transducin
Hierarchy: | ∟ ∟ ∟ ∟ ∟ Transducin 3 coordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ Transducin 3 coordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ Transducin 3 coordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ Transducin 3 coordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ Transducin 3 coordinate concepts∟ ∟ ∟ |
Broader terms: | |
Annotation: | alpha, beta and gamma transducins refer to its subunits
X |
History note: | |
historyNote*: | 89
X |
publicMeSHNote*: | 89
X |
Scope note: | A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod and cone cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore hyperpolarization of the rod cells. EC 3.6.1.-.
X |
activeMeSHYear*: | |
dateCreated*: | 1988-05-24X |
dateEstablished*: | 1989-01-01X |
dateRevised*: | 2004-07-07X |
recordAuthorizer*: | sjnX |
recordMaintainer*: | jmpX |
recordOriginator*: | RLSX |
Type: | |
Coordinate terms: | |
URI: | |
Labels and equivalent concepts: | Transdusiini (fi) XTransducin, beta Subunit (en, replaced) Transducin, gamma Subunit (en, replaced) Transducin, alpha Subunit (en, replaced) Transducin G-Protein (Gt) (en, replaced) Gt, Transducin G-Protein (en, replaced) G-Protein, Inhibitory Gt (en, replaced) |
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