ONKI3 | Medical Subject Headings

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25-Hydroxyvitamin D3 1-alpha-Hydroxylase

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Hemeproteins ∟ Cytochromes ∟ Cytochrome P-450 Enzyme System ∟ Steroid Hydroxylases ∟ 25-Hydroxyvitamin D3 1-alpha-Hydroxylase 10 coordinate concepts ∟ Aldosterone Synthase \| ∟ Aromatase \| ∟ Cholesterol 7-alpha-Hydroxylase \| ∟ Cholesterol Side-Chain Cleavage Enzyme \| ∟ Cytochrome P-450 CYP27A1 \| ∟ Steroid 11-beta-Hydroxylase \| ∟ Steroid 12-alpha-Hydroxylase \| ∟ Steroid 16-alpha-Hydroxylase \| ∟ Steroid 17-alpha-Hydroxylase \| ∟ Steroid 21-Hydroxylase Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Cytochromes ∟ Cytochrome P-450 Enzyme System ∟ Steroid Hydroxylases ∟ 25-Hydroxyvitamin D3 1-alpha-Hydroxylase 10 coordinate concepts ∟ Aldosterone Synthase \| ∟ Aromatase \| ∟ Cholesterol 7-alpha-Hydroxylase \| ∟ Cholesterol Side-Chain Cleavage Enzyme \| ∟ Cytochrome P-450 CYP27A1 \| ∟ Steroid 11-beta-Hydroxylase \| ∟ Steroid 12-alpha-Hydroxylase \| ∟ Steroid 16-alpha-Hydroxylase \| ∟ Steroid 17-alpha-Hydroxylase \| ∟ Steroid 21-Hydroxylase Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Oxidoreductases ∟ Oxygenases ∟ Mixed Function Oxygenases ∟ Cytochrome P-450 Enzyme System ∟ Steroid Hydroxylases ∟ 25-Hydroxyvitamin D3 1-alpha-Hydroxylase 10 coordinate concepts ∟ Aldosterone Synthase \| ∟ Aromatase \| ∟ Cholesterol 7-alpha-Hydroxylase \| ∟ Cholesterol Side-Chain Cleavage Enzyme \| ∟ Cytochrome P-450 CYP27A1 \| ∟ Steroid 11-beta-Hydroxylase \| ∟ Steroid 12-alpha-Hydroxylase \| ∟ Steroid 16-alpha-Hydroxylase \| ∟ Steroid 17-alpha-Hydroxylase \| ∟ Steroid 21-Hydroxylase Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Oxidoreductases ∟ Oxygenases ∟ Mixed Function Oxygenases ∟ Steroid Hydroxylases ∟ 25-Hydroxyvitamin D3 1-alpha-Hydroxylase 10 coordinate concepts ∟ Aldosterone Synthase \| ∟ Aromatase \| ∟ Cholesterol 7-alpha-Hydroxylase \| ∟ Cholesterol Side-Chain Cleavage Enzyme \| ∟ Cytochrome P-450 CYP27A1 \| ∟ Steroid 11-beta-Hydroxylase \| ∟ Steroid 12-alpha-Hydroxylase \| ∟ Steroid 16-alpha-Hydroxylase \| ∟ Steroid 17-alpha-Hydroxylase \| ∟ Steroid 21-Hydroxylase X
Broader terms:	Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Hemeproteins ∟ Cytochromes ∟ Cytochrome P-450 Enzyme System ∟ Steroid Hydroxylases ∟ 25-Hydroxyvitamin D3 1-alpha-Hydroxylase Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Cytochromes ∟ Cytochrome P-450 Enzyme System ∟ Steroid Hydroxylases ∟ 25-Hydroxyvitamin D3 1-alpha-Hydroxylase Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Oxidoreductases ∟ Oxygenases ∟ Mixed Function Oxygenases ∟ Cytochrome P-450 Enzyme System ∟ Steroid Hydroxylases ∟ 25-Hydroxyvitamin D3 1-alpha-Hydroxylase Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Oxidoreductases ∟ Oxygenases ∟ Mixed Function Oxygenases ∟ Steroid Hydroxylases ∟ 25-Hydroxyvitamin D3 1-alpha-Hydroxylase Steroid Hydroxylases > Cytochrome P-450 Enzyme System > Cytochromes > Hemeproteins > Proteins > Amino Acids, Peptides, and Proteins > Medical Subject Headings (MeSH) Steroid Hydroxylases > Cytochrome P-450 Enzyme System > Cytochromes > Enzymes and Coenzymes > Medical Subject Headings (MeSH) Steroid Hydroxylases > Cytochrome P-450 Enzyme System > Mixed Function Oxygenases > Oxygenases > Oxidoreductases > Enzymes > Enzymes and Coenzymes > Medical Subject Headings (MeSH) Steroid Hydroxylases > Mixed Function Oxygenases > Oxygenases > Oxidoreductases > Enzymes > Enzymes and Coenzymes > Medical Subject Headings (MeSH) X
History note:	Hydroxycholecalciferols (1973-1974) \| Steroid Hydroxylases (1973-1974)X
historyNote*:	2003 (1975); for 25-HYDROXYVITAMIN D2 1-HYDROXYLASE use STEROID HYDROXYLASES (NM) 1976-2002 X
publicMeSHNote*:	2003; see 25-HYDROXYCHOLECALCIFEROL 1-HYDROXYLASE 1991-2002, see STEROID HYDROXYLASES 1975-1990; 25-HYDROXYVITAMIN D2 1-HYDROXYLASE was indexed under STEROID HYDROXYLASES 1976-2002 X
Scope note:	A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol). X
activeMeSHYear*:	2005 \| 2006 \| 2007X
dateCreated*:	1974-11-19X
dateEstablished*:	1991-01-01X
dateRevised*:	2004-07-07X
recordAuthorizer*:	sjnX
recordMaintainer*:	ssbX
recordOriginator*:	NLMX
Type:	Concept X
Coordinate terms:	Aldosterone Synthase \| Aromatase \| Cholesterol 7-alpha-Hydroxylase \| Cholesterol Side-Chain Cleavage Enzyme \| Cytochrome P-450 CYP27A1 \| Steroid 11-beta-Hydroxylase \| Steroid 12-alpha-Hydroxylase \| Steroid 16-alpha-Hydroxylase \| Steroid 17-alpha-Hydroxylase \| Steroid 21-Hydroxylase X
URI:	X
Labels and equivalent concepts:	25-hydroksivitamiini D3 1-alfa-hydroksylaasi (fi) 25-hydroksikolekalsiferoli 1-hydroksylaasi (fi, replaced) 25-hydroxikolecalciferol 1-hydroxylas (sv) Calcidiol 1-Monooxygenase (en, replaced) CYP27B1 (en, replaced) Cytochrome P-450 CYP27B1 (en, replaced) 25-Hydroxyvitamin D2 1-hydroxylase (en, replaced) 25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase (en, replaced) 25-Hydroxycholecalciferol-1-Hydroxylase (en, replaced) 25-Hydroxyergocalciferol 1-alpha-Hydroxylase (en, replaced) 25-Hydroxyvitamin D 1-alpha-Hydroxylase (en, replaced) 25-Hydroxycholecalciferol 1-Hydroxylase (en, replaced) X
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