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Thalidomide
Hierarchy: | ∟ ∟ ∟ ∟ ∟ Thalidomide 6 coordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ Thalidomide 6 coordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ Thalidomide 6 coordinate concepts∟ ∟ ∟ ∟ ∟ ∟ |
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Scope note: | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppresive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
X |
activeMeSHYear*: | |
dateCreated*: | 1999-01-01X |
dateRevised*: | 2005-06-30X |
recordAuthorizer*: | sjnX |
recordMaintainer*: | CCRX |
recordOriginator*: | NLMX |
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Labels and equivalent concepts: | Talidomidi (fi) XTalidomid (sv) Neurosedyn (sv, replaced) Celgene Brand of Thalidomide (en, replaced) |
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