ONKI3 | Medical Subject Headings

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Organic Chemicals ∟ Hydrocarbons ∟ Hydrocarbons, Cyclic ∟ Hydrocarbons, Aromatic ∟ Polycyclic Hydrocarbons, Aromatic ∟ Indenes ∟ Sulindac 2 coordinate concepts ∟ Dimethindene \| ∟ Indans Medical Subject Headings (MeSH) ∟ Polycyclic Compounds ∟ Polycyclic Hydrocarbons, Aromatic ∟ Indenes ∟ Sulindac 2 coordinate concepts ∟ Dimethindene \| ∟ Indans X
Broader terms:	Medical Subject Headings (MeSH) ∟ Organic Chemicals ∟ Hydrocarbons ∟ Hydrocarbons, Cyclic ∟ Hydrocarbons, Aromatic ∟ Polycyclic Hydrocarbons, Aromatic ∟ Indenes ∟ Sulindac Medical Subject Headings (MeSH) ∟ Polycyclic Compounds ∟ Polycyclic Hydrocarbons, Aromatic ∟ Indenes ∟ Sulindac Indenes > Polycyclic Hydrocarbons, Aromatic > Hydrocarbons, Aromatic > Hydrocarbons, Cyclic > Hydrocarbons > Organic Chemicals > Medical Subject Headings (MeSH) Indenes > Polycyclic Hydrocarbons, Aromatic > Polycyclic Compounds > Medical Subject Headings (MeSH) X
History note:	Benzene (1966-1967) \| Benzene Derivatives (1968-1974) \| Benzylidene Compounds (1975-1978) \| Indenes (1966-1978)X
historyNote*:	90(79); was see under INDENES 1979-89 X
publicMeSHNote*:	90; was see under INDENES 1979-89 X
Scope note:	A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects. X
activeMeSHYear*:	2007X
dateCreated*:	1978-02-08X
dateEstablished*:	1990-01-01X
dateRevised*:	2006-07-05X
recordAuthorizer*:	sjnX
recordMaintainer*:	ssbX
recordOriginator*:	SHX
Type:	Concept X
Coordinate terms:	Dimethindene \| Indans X
URI:	X
Labels and equivalent concepts:	Sulindaakki (fi) Sulindak (sv) Clinoril (sv, replaced) Merck Sharp & Dohme Brand of Sulindac (en, replaced) Merck Brand of Sulindac (en, replaced) Novopharm Brand of Sulindac (en, replaced) Nu-Pharm Brand of Sulindac (en, replaced) Klinoril (en, replaced) Kendrick Brand of Sulindac (en, replaced) Arthrocine (en, replaced) Apotex Brand of Sulindac (en, replaced) Cahill May Roberts Brand of Sulindac (en, replaced) Chemia Brand of Sulindac (en, replaced) Chibret (en, replaced) Alphapharm Brand of Sulindac (en, replaced) Sulindacum (la-FI, replaced) X
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