ONKI3 | Medical Subject Headings

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Tissue Plasminogen Activator

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Blood Proteins ∟ Blood Coagulation Factors ∟ Plasminogen Activators ∟ Tissue Plasminogen Activator 59 coordinate concepts ∟ Anistreplase \| ∟ Streptokinase \| ∟ Urinary Plasminogen Activator \| ∟ Acrosin \| ∟ Chymases \| ∟ Chymotrypsin \| ∟ Complement Factor B \| ∟ Complement Factor D \| ∟ Complement Factor I \| ∟ D012697Q000037* \| ∟ Endopeptidase Clp \| ∟ Endopeptidase K \| ∟ Enteropeptidase \| ∟ Factor IXa \| ∟ Factor VIIa \| ∟ Factor Xa \| ∟ Factor XIa \| ∟ Factor XIIa \| ∟ Furin \| ∟ Granzymes \| ∟ Kallikreins \| ∟ Mannose-Binding Protein-Associated Serine Proteases \| ∟ Myeloblastin \| ∟ Pancreatic Elastase \| ∟ Plasmin \| ∟ Plasminogen Activators \| ∟ Pronase \| ∟ Proprotein Convertase 1 \| ∟ Proprotein Convertase 2 \| ∟ Proprotein Convertase 5 \| ∟ Protease La \| ∟ Subtilisins \| ∟ Thrombin \| ∟ Trypsin \| ∟ Tryptases \| ∟ Venombin A \| ∟ beta-Thromboglobulin \| ∟ Calcium \| ∟ D001779Q000172* \| ∟ Factor IX \| ∟ Factor V \| ∟ Factor VII \| ∟ Factor VIII \| ∟ Factor X \| ∟ Factor XI \| ∟ Factor XII \| ∟ Factor XIII \| ∟ Fibrinogen \| ∟ Fibrinopeptide A \| ∟ Fibrinopeptide B \| ∟ Kininogens \| ∟ Plasminogen Activator Inhibitor 1 \| ∟ Plasminogen Activator Inhibitor 2 \| ∟ Platelet Activating Factor \| ∟ Platelet Factor 3 \| ∟ Platelet Factor 4 \| ∟ Prothrombin \| ∟ Thromboplastin \| ∟ von Willebrand Factor Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Blood Proteins ∟ Blood Coagulation Factors ∟ Tissue Plasminogen Activator 59 coordinate concepts ∟ Anistreplase \| ∟ Streptokinase \| ∟ Urinary Plasminogen Activator \| ∟ Acrosin \| ∟ Chymases \| ∟ Chymotrypsin \| ∟ Complement Factor B \| ∟ Complement Factor D \| ∟ Complement Factor I \| ∟ D012697Q000037* \| ∟ Endopeptidase Clp \| ∟ Endopeptidase K \| ∟ Enteropeptidase \| ∟ Factor IXa \| ∟ Factor VIIa \| ∟ Factor Xa \| ∟ Factor XIa \| ∟ Factor XIIa \| ∟ Furin \| ∟ Granzymes \| ∟ Kallikreins \| ∟ Mannose-Binding Protein-Associated Serine Proteases \| ∟ Myeloblastin \| ∟ Pancreatic Elastase \| ∟ Plasmin \| ∟ Plasminogen Activators \| ∟ Pronase \| ∟ Proprotein Convertase 1 \| ∟ Proprotein Convertase 2 \| ∟ Proprotein Convertase 5 \| ∟ Protease La \| ∟ Subtilisins \| ∟ Thrombin \| ∟ Trypsin \| ∟ Tryptases \| ∟ Venombin A \| ∟ beta-Thromboglobulin \| ∟ Calcium \| ∟ D001779Q000172* \| ∟ Factor IX \| ∟ Factor V \| ∟ Factor VII \| ∟ Factor VIII \| ∟ Factor X \| ∟ Factor XI \| ∟ Factor XII \| ∟ Factor XIII \| ∟ Fibrinogen \| ∟ Fibrinopeptide A \| ∟ Fibrinopeptide B \| ∟ Kininogens \| ∟ Plasminogen Activator Inhibitor 1 \| ∟ Plasminogen Activator Inhibitor 2 \| ∟ Platelet Activating Factor \| ∟ Platelet Factor 3 \| ∟ Platelet Factor 4 \| ∟ Prothrombin \| ∟ Thromboplastin \| ∟ von Willebrand Factor Medical Subject Headings (MeSH) ∟ Biological Factors ∟ Blood Coagulation Factors ∟ Plasminogen Activators ∟ Tissue Plasminogen Activator 59 coordinate concepts ∟ Anistreplase \| ∟ Streptokinase \| ∟ Urinary Plasminogen Activator \| ∟ Acrosin \| ∟ Chymases \| ∟ Chymotrypsin \| ∟ Complement Factor B \| ∟ Complement Factor D \| ∟ Complement Factor I \| ∟ D012697Q000037* \| ∟ Endopeptidase Clp \| ∟ Endopeptidase K \| ∟ Enteropeptidase \| ∟ Factor IXa \| ∟ Factor VIIa \| ∟ Factor Xa \| ∟ Factor XIa \| ∟ Factor XIIa \| ∟ Furin \| ∟ Granzymes \| ∟ Kallikreins \| ∟ Mannose-Binding Protein-Associated Serine Proteases \| ∟ Myeloblastin \| ∟ Pancreatic Elastase \| ∟ Plasmin \| ∟ Plasminogen Activators \| ∟ Pronase \| ∟ Proprotein Convertase 1 \| ∟ Proprotein Convertase 2 \| ∟ Proprotein Convertase 5 \| ∟ Protease La \| ∟ Subtilisins \| ∟ Thrombin \| ∟ Trypsin \| ∟ Tryptases \| ∟ Venombin A \| ∟ beta-Thromboglobulin \| ∟ Calcium \| ∟ D001779Q000172* \| ∟ Factor IX \| ∟ Factor V \| ∟ Factor VII \| ∟ Factor VIII \| ∟ Factor X \| ∟ Factor XI \| ∟ Factor XII \| ∟ Factor XIII \| ∟ Fibrinogen \| ∟ Fibrinopeptide A \| ∟ Fibrinopeptide B \| ∟ Kininogens \| ∟ Plasminogen Activator Inhibitor 1 \| ∟ Plasminogen Activator Inhibitor 2 \| ∟ Platelet Activating Factor \| ∟ Platelet Factor 3 \| ∟ Platelet Factor 4 \| ∟ Prothrombin \| ∟ Thromboplastin \| ∟ von Willebrand Factor Medical Subject Headings (MeSH) ∟ Biological Factors ∟ Blood Coagulation Factors ∟ Tissue Plasminogen Activator 59 coordinate concepts ∟ Anistreplase \| ∟ Streptokinase \| ∟ Urinary Plasminogen Activator \| ∟ Acrosin \| ∟ Chymases \| ∟ Chymotrypsin \| ∟ Complement Factor B \| ∟ Complement Factor D \| ∟ Complement Factor I \| ∟ D012697Q000037* \| ∟ Endopeptidase Clp \| ∟ Endopeptidase K \| ∟ Enteropeptidase \| ∟ Factor IXa \| ∟ Factor VIIa \| ∟ Factor Xa \| ∟ Factor XIa \| ∟ Factor XIIa \| ∟ Furin \| ∟ Granzymes \| ∟ Kallikreins \| ∟ Mannose-Binding Protein-Associated Serine Proteases \| ∟ Myeloblastin \| ∟ Pancreatic Elastase \| ∟ Plasmin \| ∟ Plasminogen Activators \| ∟ Pronase \| ∟ Proprotein Convertase 1 \| ∟ Proprotein Convertase 2 \| ∟ Proprotein Convertase 5 \| ∟ Protease La \| ∟ Subtilisins \| ∟ Thrombin \| ∟ Trypsin \| ∟ Tryptases \| ∟ Venombin A \| ∟ beta-Thromboglobulin \| ∟ Calcium \| ∟ D001779Q000172* \| ∟ Factor IX \| ∟ Factor V \| ∟ Factor VII \| ∟ Factor VIII \| ∟ Factor X \| ∟ Factor XI \| ∟ Factor XII \| ∟ Factor XIII \| ∟ Fibrinogen \| ∟ Fibrinopeptide A \| ∟ Fibrinopeptide B \| ∟ Kininogens \| ∟ Plasminogen Activator Inhibitor 1 \| ∟ Plasminogen Activator Inhibitor 2 \| ∟ Platelet Activating Factor \| ∟ Platelet Factor 3 \| ∟ Platelet Factor 4 \| ∟ Prothrombin \| ∟ Thromboplastin \| ∟ von Willebrand Factor Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Hydrolases ∟ Peptide Hydrolases ∟ Endopeptidases ∟ Serine Endopeptidases ∟ Plasminogen Activators ∟ Tissue Plasminogen Activator 59 coordinate concepts ∟ Anistreplase \| ∟ Streptokinase \| ∟ Urinary Plasminogen Activator \| ∟ Acrosin \| ∟ Chymases \| ∟ Chymotrypsin \| ∟ Complement Factor B \| ∟ Complement Factor D \| ∟ Complement Factor I \| ∟ D012697Q000037* \| ∟ Endopeptidase Clp \| ∟ Endopeptidase K \| ∟ Enteropeptidase \| ∟ Factor IXa \| ∟ Factor VIIa \| ∟ Factor Xa \| ∟ Factor XIa \| ∟ Factor XIIa \| ∟ Furin \| ∟ Granzymes \| ∟ Kallikreins \| ∟ Mannose-Binding Protein-Associated Serine Proteases \| ∟ Myeloblastin \| ∟ Pancreatic Elastase \| ∟ Plasmin \| ∟ Plasminogen Activators \| ∟ Pronase \| ∟ Proprotein Convertase 1 \| ∟ Proprotein Convertase 2 \| ∟ Proprotein Convertase 5 \| ∟ Protease La \| ∟ Subtilisins \| ∟ Thrombin \| ∟ Trypsin \| ∟ Tryptases \| ∟ Venombin A \| ∟ beta-Thromboglobulin \| ∟ Calcium \| ∟ D001779Q000172* \| ∟ Factor IX \| ∟ Factor V \| ∟ Factor VII \| ∟ Factor VIII \| ∟ Factor X \| ∟ Factor XI \| ∟ Factor XII \| ∟ Factor XIII \| ∟ Fibrinogen \| ∟ Fibrinopeptide A \| ∟ Fibrinopeptide B \| ∟ Kininogens \| ∟ Plasminogen Activator Inhibitor 1 \| ∟ Plasminogen Activator Inhibitor 2 \| ∟ Platelet Activating Factor \| ∟ Platelet Factor 3 \| ∟ Platelet Factor 4 \| ∟ Prothrombin \| ∟ Thromboplastin \| ∟ von Willebrand Factor Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Hydrolases ∟ Peptide Hydrolases ∟ Endopeptidases ∟ Serine Endopeptidases ∟ Tissue Plasminogen Activator 59 coordinate concepts ∟ Anistreplase \| ∟ Streptokinase \| ∟ Urinary Plasminogen Activator \| ∟ Acrosin \| ∟ Chymases \| ∟ Chymotrypsin \| ∟ Complement Factor B \| ∟ Complement Factor D \| ∟ Complement Factor I \| ∟ D012697Q000037* \| ∟ Endopeptidase Clp \| ∟ Endopeptidase K \| ∟ Enteropeptidase \| ∟ Factor IXa \| ∟ Factor VIIa \| ∟ Factor Xa \| ∟ Factor XIa \| ∟ Factor XIIa \| ∟ Furin \| ∟ Granzymes \| ∟ Kallikreins \| ∟ Mannose-Binding Protein-Associated Serine Proteases \| ∟ Myeloblastin \| ∟ Pancreatic Elastase \| ∟ Plasmin \| ∟ Plasminogen Activators \| ∟ Pronase \| ∟ Proprotein Convertase 1 \| ∟ Proprotein Convertase 2 \| ∟ Proprotein Convertase 5 \| ∟ Protease La \| ∟ Subtilisins \| ∟ Thrombin \| ∟ Trypsin \| ∟ Tryptases \| ∟ Venombin A \| ∟ beta-Thromboglobulin \| ∟ Calcium \| ∟ D001779Q000172* \| ∟ Factor IX \| ∟ Factor V \| ∟ Factor VII \| ∟ Factor VIII \| ∟ Factor X \| ∟ Factor XI \| ∟ Factor XII \| ∟ Factor XIII \| ∟ Fibrinogen \| ∟ Fibrinopeptide A \| ∟ Fibrinopeptide B \| ∟ Kininogens \| ∟ Plasminogen Activator Inhibitor 1 \| ∟ Plasminogen Activator Inhibitor 2 \| ∟ Platelet Activating Factor \| ∟ Platelet Factor 3 \| ∟ Platelet Factor 4 \| ∟ Prothrombin \| ∟ Thromboplastin \| ∟ von Willebrand Factor X
Broader terms:	Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Blood Proteins ∟ Blood Coagulation Factors ∟ Plasminogen Activators ∟ Tissue Plasminogen Activator Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Blood Proteins ∟ Blood Coagulation Factors ∟ Tissue Plasminogen Activator Medical Subject Headings (MeSH) ∟ Biological Factors ∟ Blood Coagulation Factors ∟ Plasminogen Activators ∟ Tissue Plasminogen Activator Medical Subject Headings (MeSH) ∟ Biological Factors ∟ Blood Coagulation Factors ∟ Tissue Plasminogen Activator Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Hydrolases ∟ Peptide Hydrolases ∟ Endopeptidases ∟ Serine Endopeptidases ∟ Plasminogen Activators ∟ Tissue Plasminogen Activator Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Hydrolases ∟ Peptide Hydrolases ∟ Endopeptidases ∟ Serine Endopeptidases ∟ Tissue Plasminogen Activator Plasminogen Activators > Blood Coagulation Factors > Blood Proteins > Proteins > Amino Acids, Peptides, and Proteins > Medical Subject Headings (MeSH) Blood Coagulation Factors > Blood Proteins > Proteins > Amino Acids, Peptides, and Proteins > Medical Subject Headings (MeSH) Plasminogen Activators > Blood Coagulation Factors > Biological Factors > Medical Subject Headings (MeSH) Blood Coagulation Factors > Biological Factors > Medical Subject Headings (MeSH) Plasminogen Activators > Serine Endopeptidases > Endopeptidases > Peptide Hydrolases > Hydrolases > Enzymes > Enzymes and Coenzymes > Medical Subject Headings (MeSH) Serine Endopeptidases > Endopeptidases > Peptide Hydrolases > Hydrolases > Enzymes > Enzymes and Coenzymes > Medical Subject Headings (MeSH) X
Annotation:	DF: TTPA X
History note:	Enzyme Activation (1974-1975) \| Peptide Hydrolases (1975) \| Plasminogen Activators (1976-1985)X
historyNote*:	98(86) X
publicMeSHNote*:	98; see ALTEPLASE 1992-97; see PLASMINOGEN ACTIVATOR, TISSUE-TYPE 1986-91 X
Scope note:	A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to PLASMIN. It has fibrin-binding activity and is immunologically different from URINARY PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases. EC 3.4.21.68. X
activeMeSHYear*:	2006 \| 2007X
dateCreated*:	1985-06-12X
dateEstablished*:	1986-01-01X
dateRevised*:	2005-06-30X
recordAuthorizer*:	sjnX
recordMaintainer*:	ssbX
recordOriginator*:	RLSX
Type:	Concept X
Coordinate terms:	Anistreplase \| Streptokinase \| Urinary Plasminogen Activator \| Acrosin \| Chymases \| Chymotrypsin \| Complement Factor B \| Complement Factor D \| Complement Factor I \| D012697Q000037* \| Endopeptidase Clp \| Endopeptidase K \| Enteropeptidase \| Factor IXa \| Factor VIIa \| Factor Xa \| Factor XIa \| Factor XIIa \| Furin \| Granzymes \| Kallikreins \| Mannose-Binding Protein-Associated Serine Proteases \| Myeloblastin \| Pancreatic Elastase \| Plasmin \| Plasminogen Activators \| Pronase \| Proprotein Convertase 1 \| Proprotein Convertase 2 \| Proprotein Convertase 5 \| Protease La \| Subtilisins \| Thrombin \| Trypsin \| Tryptases \| Venombin A \| beta-Thromboglobulin \| Calcium \| D001779Q000172* \| Factor IX \| Factor V \| Factor VII \| Factor VIII \| Factor X \| Factor XI \| Factor XII \| Factor XIII \| Fibrinogen \| Fibrinopeptide A \| Fibrinopeptide B \| Kininogens \| Plasminogen Activator Inhibitor 1 \| Plasminogen Activator Inhibitor 2 \| Platelet Activating Factor \| Platelet Factor 3 \| Platelet Factor 4 \| Prothrombin \| Thromboplastin \| von Willebrand Factor X
URI:	X
Labels and equivalent concepts:	Kudoksen plasminogeenin aktivaattori (fi) TPA (fi, replaced) T-PA (fi, replaced) Vävnadsplasminogenaktivator (sv) Alteplas (sv, replaced) Cellplasminogenaktivator (sv, replaced) Vävnadsaktivator (sv, replaced) TPA (sv, replaced) Kärlaktivator (sv, replaced) TTPA (en, replaced) Tissue-Type Plasminogen Activator (en, replaced) Tissue Activator D-44 (en, replaced) Hoffmann-La Roche Brand of Alteplase (en, replaced) Genentech Brand of Alteplase (en, replaced) Boehringer Ingelheim Brand of Alteplase (en, replaced) Lysatec rt-PA (en, replaced) Plasminogen Activator, Tissue-Type (en, replaced) T-Plasminogen Activator (en, replaced) Promeco Brand of Alteplase (en, replaced) Alteplase (en, replaced) X
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