ONKI3 | Medical Subject Headings

The ONKI is provided as a part of the ONKI Living Lab - an open lab for testing the latest semantic web technologies in practice, with real users like you. Currently, over 10 000 people are using ONKI each month.

We hope you like the ONKI service and enjoy using it for your purposes!

If you encounter any problems or have improvement ideas, please contact the ONKI team. We are also very much interested in your success stories in using ONKI - please share your experiences!

The ONKI Team

Jouni Tuominen, Living Lab contact person, APIs, widgets, publishing of ontologies, etc.
Eero Hyvönen, professor, head of research group

Former members: Kim Viljanen, Rami Alatalo.

Building the future of the Semantic Web and beyond.

SeCo's homepage
For the latest semantic news, follow us on Twitter and fan us on Facebook!

How can we help you?

Live presentations about ONKI: what it is? how to use it?
Support for creating and publishing ontologies.
Online technical support for using ONKI.
Co-operation in projects.
And more, please ask.

suomeksi på svenska in English

The way property values are displayed: value/row values side by side

The way concept relations are shown: separately in hierarchy

Nucleic Acid Denaturation

Loading results...


Hierarchy:	Medical Subject Headings (MeSH) ∟ Biochemical Phenomena, Metabolism, and Nutrition ∟ Biochemical Phenomena ∟ Nucleic Acid Denaturation 83 coordinate concepts ∟ Breeding \| ∟ Cell Division \| ∟ DNA Cleavage \| ∟ DNA Damage \| ∟ DNA Methylation \| ∟ DNA Packaging \| ∟ DNA Repair \| ∟ DNA Replication \| ∟ Evolution \| ∟ Gene Expression \| ∟ Gene Expression Regulation \| ∟ Gene Rearrangement \| ∟ Heredity \| ∟ Mutagenesis \| ∟ Nuclear Reprogramming \| ∟ Recombination, Genetic \| ∟ Selection (Genetics) \| ∟ Sex Determination (Genetics) \| ∟ Virus Integration \| ∟ Chromatin Immunoprecipitation \| ∟ Chromosome Mapping \| ∟ Cloning, Molecular \| ∟ Cloning, Organism \| ∟ Contig Mapping \| ∟ Crosses, Genetic \| ∟ Cytogenetic Analysis \| ∟ DNA Fingerprinting \| ∟ DNA Footprinting \| ∟ Epidemiology, Molecular \| ∟ Gene Expression Profiling \| ∟ Gene Targeting \| ∟ Gene Transfer Techniques \| ∟ Genetic Engineering \| ∟ Heterozygote Detection \| ∟ In Situ Nick-End Labeling \| ∟ Molecular Diagnostic Techniques \| ∟ Molecular Probe Techniques \| ∟ Mutagenicity Tests \| ∟ Nuclear Transfer Techniques \| ∟ Nuclease Protection Assays \| ∟ Nucleic Acid Amplification Techniques \| ∟ Nucleic Acid Hybridization \| ∟ Pedigree \| ∟ Restriction Mapping \| ∟ Sequence Alignment \| ∟ Sequence Analysis \| ∟ Acid-Base Equilibrium \| ∟ Aerobiosis \| ∟ Allosteric Regulation \| ∟ Amino Acid Substitution \| ∟ Anaerobiosis \| ∟ Base Composition \| ∟ Binding Sites \| ∟ Body Composition \| ∟ Brain Chemistry \| ∟ Calcification, Physiologic \| ∟ Diffusion \| ∟ Down-Regulation \| ∟ Energy Transfer \| ∟ Enzyme Activation \| ∟ Enzyme Stability \| ∟ Fermentation \| ∟ Ion Transport \| ∟ Membrane Fluidity \| ∟ Molecular Mimicry \| ∟ Molecular Structure \| ∟ Nitrogen Fixation \| ∟ Nitrosation \| ∟ Nucleic Acid Renaturation \| ∟ Osmosis \| ∟ Protein Binding \| ∟ Protein Denaturation \| ∟ Protein Folding \| ∟ Protein Hybridization \| ∟ Protein Renaturation \| ∟ RNA Stability \| ∟ Sequence Homology \| ∟ Signal Transduction \| ∟ Structure-Activity Relationship \| ∟ Substrate Specificity \| ∟ Up-Regulation \| ∟ Virus Replication \| ∟ Water-Electrolyte Balance Medical Subject Headings (MeSH) ∟ Genetic Processes ∟ Nucleic Acid Denaturation 83 coordinate concepts ∟ Breeding \| ∟ Cell Division \| ∟ DNA Cleavage \| ∟ DNA Damage \| ∟ DNA Methylation \| ∟ DNA Packaging \| ∟ DNA Repair \| ∟ DNA Replication \| ∟ Evolution \| ∟ Gene Expression \| ∟ Gene Expression Regulation \| ∟ Gene Rearrangement \| ∟ Heredity \| ∟ Mutagenesis \| ∟ Nuclear Reprogramming \| ∟ Recombination, Genetic \| ∟ Selection (Genetics) \| ∟ Sex Determination (Genetics) \| ∟ Virus Integration \| ∟ Chromatin Immunoprecipitation \| ∟ Chromosome Mapping \| ∟ Cloning, Molecular \| ∟ Cloning, Organism \| ∟ Contig Mapping \| ∟ Crosses, Genetic \| ∟ Cytogenetic Analysis \| ∟ DNA Fingerprinting \| ∟ DNA Footprinting \| ∟ Epidemiology, Molecular \| ∟ Gene Expression Profiling \| ∟ Gene Targeting \| ∟ Gene Transfer Techniques \| ∟ Genetic Engineering \| ∟ Heterozygote Detection \| ∟ In Situ Nick-End Labeling \| ∟ Molecular Diagnostic Techniques \| ∟ Molecular Probe Techniques \| ∟ Mutagenicity Tests \| ∟ Nuclear Transfer Techniques \| ∟ Nuclease Protection Assays \| ∟ Nucleic Acid Amplification Techniques \| ∟ Nucleic Acid Hybridization \| ∟ Pedigree \| ∟ Restriction Mapping \| ∟ Sequence Alignment \| ∟ Sequence Analysis \| ∟ Acid-Base Equilibrium \| ∟ Aerobiosis \| ∟ Allosteric Regulation \| ∟ Amino Acid Substitution \| ∟ Anaerobiosis \| ∟ Base Composition \| ∟ Binding Sites \| ∟ Body Composition \| ∟ Brain Chemistry \| ∟ Calcification, Physiologic \| ∟ Diffusion \| ∟ Down-Regulation \| ∟ Energy Transfer \| ∟ Enzyme Activation \| ∟ Enzyme Stability \| ∟ Fermentation \| ∟ Ion Transport \| ∟ Membrane Fluidity \| ∟ Molecular Mimicry \| ∟ Molecular Structure \| ∟ Nitrogen Fixation \| ∟ Nitrosation \| ∟ Nucleic Acid Renaturation \| ∟ Osmosis \| ∟ Protein Binding \| ∟ Protein Denaturation \| ∟ Protein Folding \| ∟ Protein Hybridization \| ∟ Protein Renaturation \| ∟ RNA Stability \| ∟ Sequence Homology \| ∟ Signal Transduction \| ∟ Structure-Activity Relationship \| ∟ Substrate Specificity \| ∟ Up-Regulation \| ∟ Virus Replication \| ∟ Water-Electrolyte Balance Medical Subject Headings (MeSH) ∟ Investigative Techniques ∟ Genetic Techniques ∟ Nucleic Acid Denaturation 83 coordinate concepts ∟ Breeding \| ∟ Cell Division \| ∟ DNA Cleavage \| ∟ DNA Damage \| ∟ DNA Methylation \| ∟ DNA Packaging \| ∟ DNA Repair \| ∟ DNA Replication \| ∟ Evolution \| ∟ Gene Expression \| ∟ Gene Expression Regulation \| ∟ Gene Rearrangement \| ∟ Heredity \| ∟ Mutagenesis \| ∟ Nuclear Reprogramming \| ∟ Recombination, Genetic \| ∟ Selection (Genetics) \| ∟ Sex Determination (Genetics) \| ∟ Virus Integration \| ∟ Chromatin Immunoprecipitation \| ∟ Chromosome Mapping \| ∟ Cloning, Molecular \| ∟ Cloning, Organism \| ∟ Contig Mapping \| ∟ Crosses, Genetic \| ∟ Cytogenetic Analysis \| ∟ DNA Fingerprinting \| ∟ DNA Footprinting \| ∟ Epidemiology, Molecular \| ∟ Gene Expression Profiling \| ∟ Gene Targeting \| ∟ Gene Transfer Techniques \| ∟ Genetic Engineering \| ∟ Heterozygote Detection \| ∟ In Situ Nick-End Labeling \| ∟ Molecular Diagnostic Techniques \| ∟ Molecular Probe Techniques \| ∟ Mutagenicity Tests \| ∟ Nuclear Transfer Techniques \| ∟ Nuclease Protection Assays \| ∟ Nucleic Acid Amplification Techniques \| ∟ Nucleic Acid Hybridization \| ∟ Pedigree \| ∟ Restriction Mapping \| ∟ Sequence Alignment \| ∟ Sequence Analysis \| ∟ Acid-Base Equilibrium \| ∟ Aerobiosis \| ∟ Allosteric Regulation \| ∟ Amino Acid Substitution \| ∟ Anaerobiosis \| ∟ Base Composition \| ∟ Binding Sites \| ∟ Body Composition \| ∟ Brain Chemistry \| ∟ Calcification, Physiologic \| ∟ Diffusion \| ∟ Down-Regulation \| ∟ Energy Transfer \| ∟ Enzyme Activation \| ∟ Enzyme Stability \| ∟ Fermentation \| ∟ Ion Transport \| ∟ Membrane Fluidity \| ∟ Molecular Mimicry \| ∟ Molecular Structure \| ∟ Nitrogen Fixation \| ∟ Nitrosation \| ∟ Nucleic Acid Renaturation \| ∟ Osmosis \| ∟ Protein Binding \| ∟ Protein Denaturation \| ∟ Protein Folding \| ∟ Protein Hybridization \| ∟ Protein Renaturation \| ∟ RNA Stability \| ∟ Sequence Homology \| ∟ Signal Transduction \| ∟ Structure-Activity Relationship \| ∟ Substrate Specificity \| ∟ Up-Regulation \| ∟ Virus Replication \| ∟ Water-Electrolyte Balance X
Broader terms:	Medical Subject Headings (MeSH) ∟ Biochemical Phenomena, Metabolism, and Nutrition ∟ Biochemical Phenomena ∟ Nucleic Acid Denaturation Medical Subject Headings (MeSH) ∟ Genetic Processes ∟ Nucleic Acid Denaturation Medical Subject Headings (MeSH) ∟ Investigative Techniques ∟ Genetic Techniques ∟ Nucleic Acid Denaturation Biochemical Phenomena > Biochemical Phenomena, Metabolism, and Nutrition > Medical Subject Headings (MeSH) Genetic Processes > Medical Subject Headings (MeSH) Genetic Techniques > Investigative Techniques > Medical Subject Headings (MeSH) X
Annotation:	IM general only; coord NIM with DNA or RNA or specific (IM) X
historyNote*:	70(67) X
publicMeSHNote*:	70 X
Scope note:	Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible. X
activeMeSHYear*:	2007X
dateCreated*:	1999-01-01X
dateEstablished*:	1970-01-01X
dateRevised*:	2006-07-05X
recordAuthorizer*:	sjnX
recordMaintainer*:	nnsX
recordOriginator*:	NLMX
Related term:	RNA Stability X
Type:	Concept X
Coordinate terms:	Breeding \| Cell Division \| DNA Cleavage \| DNA Damage \| DNA Methylation \| DNA Packaging \| DNA Repair \| DNA Replication \| Evolution \| Gene Expression \| Gene Expression Regulation \| Gene Rearrangement \| Heredity \| Mutagenesis \| Nuclear Reprogramming \| Recombination, Genetic \| Selection (Genetics) \| Sex Determination (Genetics) \| Virus Integration \| Chromatin Immunoprecipitation \| Chromosome Mapping \| Cloning, Molecular \| Cloning, Organism \| Contig Mapping \| Crosses, Genetic \| Cytogenetic Analysis \| DNA Fingerprinting \| DNA Footprinting \| Epidemiology, Molecular \| Gene Expression Profiling \| Gene Targeting \| Gene Transfer Techniques \| Genetic Engineering \| Heterozygote Detection \| In Situ Nick-End Labeling \| Molecular Diagnostic Techniques \| Molecular Probe Techniques \| Mutagenicity Tests \| Nuclear Transfer Techniques \| Nuclease Protection Assays \| Nucleic Acid Amplification Techniques \| Nucleic Acid Hybridization \| Pedigree \| Restriction Mapping \| Sequence Alignment \| Sequence Analysis \| Acid-Base Equilibrium \| Aerobiosis \| Allosteric Regulation \| Amino Acid Substitution \| Anaerobiosis \| Base Composition \| Binding Sites \| Body Composition \| Brain Chemistry \| Calcification, Physiologic \| Diffusion \| Down-Regulation \| Energy Transfer \| Enzyme Activation \| Enzyme Stability \| Fermentation \| Ion Transport \| Membrane Fluidity \| Molecular Mimicry \| Molecular Structure \| Nitrogen Fixation \| Nitrosation \| Nucleic Acid Renaturation \| Osmosis \| Protein Binding \| Protein Denaturation \| Protein Folding \| Protein Hybridization \| Protein Renaturation \| RNA Stability \| Sequence Homology \| Signal Transduction \| Structure-Activity Relationship \| Substrate Specificity \| Up-Regulation \| Virus Replication \| Water-Electrolyte Balance X
URI:	X
Labels and equivalent concepts:	Nukleiinihappojen denaturaatio (fi) Nukleiinihapon denaturaatio (fi, replaced) Nukleinsyradenaturation (sv) DNA Melting (en, replaced) X
Share:	X