ONKI3 | Medical Subject Headings

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The way property values are displayed: value/row values side by side

The way concept relations are shown: separately in hierarchy

Leukodystrophy, Metachromatic

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Heredodegenerative Disorders, Nervous System ∟ Hereditary Central Nervous System Demyelinating Diseases ∟ Leukodystrophy, Metachromatic 6 coordinate concepts ∟ Adrenoleukodystrophy \| ∟ Alexander Disease \| ∟ Canavan Disease \| ∟ Leukodystrophy, Globoid Cell \| ∟ Pelizaeus-Merzbacher Disease \| ∟ Multiple Sulfatase Deficiency Disease Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Metabolism, Inborn Errors ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Sulfatidosis ∟ Leukodystrophy, Metachromatic 6 coordinate concepts ∟ Adrenoleukodystrophy \| ∟ Alexander Disease \| ∟ Canavan Disease \| ∟ Leukodystrophy, Globoid Cell \| ∟ Pelizaeus-Merzbacher Disease \| ∟ Multiple Sulfatase Deficiency Disease Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Metabolism, Inborn Errors ∟ Lipid Metabolism, Inborn Errors ∟ Lipidoses ∟ Sphingolipidoses ∟ Sulfatidosis ∟ Leukodystrophy, Metachromatic 6 coordinate concepts ∟ Adrenoleukodystrophy \| ∟ Alexander Disease \| ∟ Canavan Disease \| ∟ Leukodystrophy, Globoid Cell \| ∟ Pelizaeus-Merzbacher Disease \| ∟ Multiple Sulfatase Deficiency Disease Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Metabolism, Inborn Errors ∟ Lysosomal Storage Diseases ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Sulfatidosis ∟ Leukodystrophy, Metachromatic 6 coordinate concepts ∟ Adrenoleukodystrophy \| ∟ Alexander Disease \| ∟ Canavan Disease \| ∟ Leukodystrophy, Globoid Cell \| ∟ Pelizaeus-Merzbacher Disease \| ∟ Multiple Sulfatase Deficiency Disease Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Central Nervous System Diseases ∟ Brain Diseases ∟ Brain Diseases, Metabolic ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Sulfatidosis ∟ Leukodystrophy, Metachromatic 6 coordinate concepts ∟ Adrenoleukodystrophy \| ∟ Alexander Disease \| ∟ Canavan Disease \| ∟ Leukodystrophy, Globoid Cell \| ∟ Pelizaeus-Merzbacher Disease \| ∟ Multiple Sulfatase Deficiency Disease Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Demyelinating Diseases ∟ Hereditary Central Nervous System Demyelinating Diseases ∟ Leukodystrophy, Metachromatic 6 coordinate concepts ∟ Adrenoleukodystrophy \| ∟ Alexander Disease \| ∟ Canavan Disease \| ∟ Leukodystrophy, Globoid Cell \| ∟ Pelizaeus-Merzbacher Disease \| ∟ Multiple Sulfatase Deficiency Disease Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Neurodegenerative Diseases ∟ Heredodegenerative Disorders, Nervous System ∟ Hereditary Central Nervous System Demyelinating Diseases ∟ Leukodystrophy, Metachromatic 6 coordinate concepts ∟ Adrenoleukodystrophy \| ∟ Alexander Disease \| ∟ Canavan Disease \| ∟ Leukodystrophy, Globoid Cell \| ∟ Pelizaeus-Merzbacher Disease \| ∟ Multiple Sulfatase Deficiency Disease Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Brain Diseases, Metabolic ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Sulfatidosis ∟ Leukodystrophy, Metachromatic 6 coordinate concepts ∟ Adrenoleukodystrophy \| ∟ Alexander Disease \| ∟ Canavan Disease \| ∟ Leukodystrophy, Globoid Cell \| ∟ Pelizaeus-Merzbacher Disease \| ∟ Multiple Sulfatase Deficiency Disease Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Lipid Metabolism Disorders ∟ Lipidoses ∟ Sphingolipidoses ∟ Sulfatidosis ∟ Leukodystrophy, Metachromatic 6 coordinate concepts ∟ Adrenoleukodystrophy \| ∟ Alexander Disease \| ∟ Canavan Disease \| ∟ Leukodystrophy, Globoid Cell \| ∟ Pelizaeus-Merzbacher Disease \| ∟ Multiple Sulfatase Deficiency Disease Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Metabolism, Inborn Errors ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Sulfatidosis ∟ Leukodystrophy, Metachromatic 6 coordinate concepts ∟ Adrenoleukodystrophy \| ∟ Alexander Disease \| ∟ Canavan Disease \| ∟ Leukodystrophy, Globoid Cell \| ∟ Pelizaeus-Merzbacher Disease \| ∟ Multiple Sulfatase Deficiency Disease Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Metabolism, Inborn Errors ∟ Lipid Metabolism, Inborn Errors ∟ Lipidoses ∟ Sphingolipidoses ∟ Sulfatidosis ∟ Leukodystrophy, Metachromatic 6 coordinate concepts ∟ Adrenoleukodystrophy \| ∟ Alexander Disease \| ∟ Canavan Disease \| ∟ Leukodystrophy, Globoid Cell \| ∟ Pelizaeus-Merzbacher Disease \| ∟ Multiple Sulfatase Deficiency Disease Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Metabolism, Inborn Errors ∟ Lysosomal Storage Diseases ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Sulfatidosis ∟ Leukodystrophy, Metachromatic 6 coordinate concepts ∟ Adrenoleukodystrophy \| ∟ Alexander Disease \| ∟ Canavan Disease \| ∟ Leukodystrophy, Globoid Cell \| ∟ Pelizaeus-Merzbacher Disease \| ∟ Multiple Sulfatase Deficiency Disease X
Broader terms:	Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Heredodegenerative Disorders, Nervous System ∟ Hereditary Central Nervous System Demyelinating Diseases ∟ Leukodystrophy, Metachromatic Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Metabolism, Inborn Errors ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Sulfatidosis ∟ Leukodystrophy, Metachromatic Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Metabolism, Inborn Errors ∟ Lipid Metabolism, Inborn Errors ∟ Lipidoses ∟ Sphingolipidoses ∟ Sulfatidosis ∟ Leukodystrophy, Metachromatic Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Metabolism, Inborn Errors ∟ Lysosomal Storage Diseases ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Sulfatidosis ∟ Leukodystrophy, Metachromatic Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Central Nervous System Diseases ∟ Brain Diseases ∟ Brain Diseases, Metabolic ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Sulfatidosis ∟ Leukodystrophy, Metachromatic Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Demyelinating Diseases ∟ Hereditary Central Nervous System Demyelinating Diseases ∟ Leukodystrophy, Metachromatic Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Neurodegenerative Diseases ∟ Heredodegenerative Disorders, Nervous System ∟ Hereditary Central Nervous System Demyelinating Diseases ∟ Leukodystrophy, Metachromatic Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Brain Diseases, Metabolic ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Sulfatidosis ∟ Leukodystrophy, Metachromatic Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Lipid Metabolism Disorders ∟ Lipidoses ∟ Sphingolipidoses ∟ Sulfatidosis ∟ Leukodystrophy, Metachromatic Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Metabolism, Inborn Errors ∟ Brain Diseases, Metabolic, Inborn ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Sulfatidosis ∟ Leukodystrophy, Metachromatic Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Metabolism, Inborn Errors ∟ Lipid Metabolism, Inborn Errors ∟ Lipidoses ∟ Sphingolipidoses ∟ Sulfatidosis ∟ Leukodystrophy, Metachromatic Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Metabolism, Inborn Errors ∟ Lysosomal Storage Diseases ∟ Lysosomal Storage Diseases, Nervous System ∟ Sphingolipidoses ∟ Sulfatidosis ∟ Leukodystrophy, Metachromatic Hereditary Central Nervous System Demyelinating Diseases > Heredodegenerative Disorders, Nervous System > Genetic Diseases, Inborn > Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Medical Subject Headings (MeSH) Sulfatidosis > Sphingolipidoses > Lysosomal Storage Diseases, Nervous System > Brain Diseases, Metabolic, Inborn > Metabolism, Inborn Errors > Genetic Diseases, Inborn > Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Medical Subject Headings (MeSH) Sulfatidosis > Sphingolipidoses > Lipidoses > Lipid Metabolism, Inborn Errors > Metabolism, Inborn Errors > Genetic Diseases, Inborn > Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Medical Subject Headings (MeSH) Sulfatidosis > Sphingolipidoses > Lysosomal Storage Diseases, Nervous System > Lysosomal Storage Diseases > Metabolism, Inborn Errors > Genetic Diseases, Inborn > Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Medical Subject Headings (MeSH) Sulfatidosis > Sphingolipidoses > Lysosomal Storage Diseases, Nervous System > Brain Diseases, Metabolic, Inborn > Brain Diseases, Metabolic > Brain Diseases > Central Nervous System Diseases > Nervous System Diseases > Medical Subject Headings (MeSH) Hereditary Central Nervous System Demyelinating Diseases > Demyelinating Diseases > Nervous System Diseases > Medical Subject Headings (MeSH) Hereditary Central Nervous System Demyelinating Diseases > Heredodegenerative Disorders, Nervous System > Neurodegenerative Diseases > Nervous System Diseases > Medical Subject Headings (MeSH) Sulfatidosis > Sphingolipidoses > Lysosomal Storage Diseases, Nervous System > Brain Diseases, Metabolic, Inborn > Brain Diseases, Metabolic > Metabolic Diseases > Nutritional and Metabolic Diseases > Medical Subject Headings (MeSH) Sulfatidosis > Sphingolipidoses > Lipidoses > Lipid Metabolism Disorders > Metabolic Diseases > Nutritional and Metabolic Diseases > Medical Subject Headings (MeSH) Sulfatidosis > Sphingolipidoses > Lysosomal Storage Diseases, Nervous System > Brain Diseases, Metabolic, Inborn > Metabolism, Inborn Errors > Metabolic Diseases > Nutritional and Metabolic Diseases > Medical Subject Headings (MeSH) Sulfatidosis > Sphingolipidoses > Lipidoses > Lipid Metabolism, Inborn Errors > Metabolism, Inborn Errors > Metabolic Diseases > Nutritional and Metabolic Diseases > Medical Subject Headings (MeSH) Sulfatidosis > Sphingolipidoses > Lysosomal Storage Diseases, Nervous System > Lysosomal Storage Diseases > Metabolism, Inborn Errors > Metabolic Diseases > Nutritional and Metabolic Diseases > Medical Subject Headings (MeSH) X
historyNote*:	1974 X
publicMeSHNote*:	1974 X
Scope note:	An autosomal recessive metabolic disease caused by a deficiency of arylsulfatase A (CEREBROSIDE-SULFATASE) leading to intralysosomal accumulation of cerebroside sulfate (SULFOGLYCOSPHINGOLIPIDS) in the nervous system and other organs. Pathological features include diffuse demyelination, and metachromatically-staining granules in many cell types such as the GLIAL CELLS. There are several allelic and nonallelic forms with a variety of neurological symptoms. X
activeMeSHYear*:	2007X
dateCreated*:	1999-01-01X
dateEstablished*:	1974-01-01X
dateRevised*:	2006-07-05X
recordAuthorizer*:	sjnX
recordMaintainer*:	lktX
recordOriginator*:	NLMX
Related term:	Cerebroside-Sulfatase X
Type:	Concept X
Coordinate terms:	Adrenoleukodystrophy \| Alexander Disease \| Canavan Disease \| Leukodystrophy, Globoid Cell \| Pelizaeus-Merzbacher Disease \| Multiple Sulfatase Deficiency Disease X
URI:	X
Labels and equivalent concepts:	Metakromaattinen leukodystrofia (fi) MLD (fi, replaced) Leukodystrofi, metakromatisk (sv) Metakromatisk leukodystrofi (sv, replaced) Sulfatide Lipidosis (en, replaced) Metachromatic Leukodystrophy, Juvenile-Type (en, replaced) Metachromatic Leukodystrophy, Infant-Type (en, replaced) Cerebroside Sulphatase Deficiency Disease (en, replaced) Greenfield Disease (en, replaced) Greenfield's Disease (en, replaced) Metachromatic Leukodystrophy, Adult-Type (en, replaced) Arylsulfatase A Deficiency Disease (en, replaced) Leucodystrophia metachromatica (la-FI, replaced) X
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