ONKI3 | Medical Subject Headings

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Kearns-Sayer Syndrome

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Cardiovascular Diseases ∟ Heart Diseases ∟ Cardiomyopathies ∟ Kearns-Sayer Syndrome 11 coordinate concepts ∟ Usher Syndromes \| ∟ Cardiomyopathy, Alcoholic \| ∟ Cardiomyopathy, Dilated \| ∟ Cardiomyopathy, Hypertrophic \| ∟ Cardiomyopathy, Restrictive \| ∟ Chagas Cardiomyopathy \| ∟ Endocardial Fibroelastosis \| ∟ Endomyocardial Fibrosis \| ∟ Glycogen Storage Disease Type IIb \| ∟ Myocardial Reperfusion Injury \| ∟ Myocarditis Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Eye Diseases, Hereditary ∟ Retinitis Pigmentosa ∟ Kearns-Sayer Syndrome 11 coordinate concepts ∟ Usher Syndromes \| ∟ Cardiomyopathy, Alcoholic \| ∟ Cardiomyopathy, Dilated \| ∟ Cardiomyopathy, Hypertrophic \| ∟ Cardiomyopathy, Restrictive \| ∟ Chagas Cardiomyopathy \| ∟ Endocardial Fibroelastosis \| ∟ Endomyocardial Fibrosis \| ∟ Glycogen Storage Disease Type IIb \| ∟ Myocardial Reperfusion Injury \| ∟ Myocarditis Medical Subject Headings (MeSH) ∟ Eye Diseases ∟ Eye Diseases, Hereditary ∟ Retinitis Pigmentosa ∟ Kearns-Sayer Syndrome 11 coordinate concepts ∟ Usher Syndromes \| ∟ Cardiomyopathy, Alcoholic \| ∟ Cardiomyopathy, Dilated \| ∟ Cardiomyopathy, Hypertrophic \| ∟ Cardiomyopathy, Restrictive \| ∟ Chagas Cardiomyopathy \| ∟ Endocardial Fibroelastosis \| ∟ Endomyocardial Fibrosis \| ∟ Glycogen Storage Disease Type IIb \| ∟ Myocardial Reperfusion Injury \| ∟ Myocarditis Medical Subject Headings (MeSH) ∟ Eye Diseases ∟ Ocular Motility Disorders ∟ Ophthalmoplegia ∟ Ophthalmoplegia, Chronic Progressive External ∟ Kearns-Sayer Syndrome 11 coordinate concepts ∟ Usher Syndromes \| ∟ Cardiomyopathy, Alcoholic \| ∟ Cardiomyopathy, Dilated \| ∟ Cardiomyopathy, Hypertrophic \| ∟ Cardiomyopathy, Restrictive \| ∟ Chagas Cardiomyopathy \| ∟ Endocardial Fibroelastosis \| ∟ Endomyocardial Fibrosis \| ∟ Glycogen Storage Disease Type IIb \| ∟ Myocardial Reperfusion Injury \| ∟ Myocarditis Medical Subject Headings (MeSH) ∟ Eye Diseases ∟ Ocular Motility Disorders ∟ Ophthalmoplegia, Chronic Progressive External ∟ Kearns-Sayer Syndrome 11 coordinate concepts ∟ Usher Syndromes \| ∟ Cardiomyopathy, Alcoholic \| ∟ Cardiomyopathy, Dilated \| ∟ Cardiomyopathy, Hypertrophic \| ∟ Cardiomyopathy, Restrictive \| ∟ Chagas Cardiomyopathy \| ∟ Endocardial Fibroelastosis \| ∟ Endomyocardial Fibrosis \| ∟ Glycogen Storage Disease Type IIb \| ∟ Myocardial Reperfusion Injury \| ∟ Myocarditis Medical Subject Headings (MeSH) ∟ Eye Diseases ∟ Retinal Diseases ∟ Retinal Degeneration ∟ Retinitis Pigmentosa ∟ Kearns-Sayer Syndrome 11 coordinate concepts ∟ Usher Syndromes \| ∟ Cardiomyopathy, Alcoholic \| ∟ Cardiomyopathy, Dilated \| ∟ Cardiomyopathy, Hypertrophic \| ∟ Cardiomyopathy, Restrictive \| ∟ Chagas Cardiomyopathy \| ∟ Endocardial Fibroelastosis \| ∟ Endomyocardial Fibrosis \| ∟ Glycogen Storage Disease Type IIb \| ∟ Myocardial Reperfusion Injury \| ∟ Myocarditis Medical Subject Headings (MeSH) ∟ Musculoskeletal Diseases ∟ Muscular Diseases ∟ Mitochondrial Myopathies ∟ Ophthalmoplegia, Chronic Progressive External ∟ Kearns-Sayer Syndrome 11 coordinate concepts ∟ Usher Syndromes \| ∟ Cardiomyopathy, Alcoholic \| ∟ Cardiomyopathy, Dilated \| ∟ Cardiomyopathy, Hypertrophic \| ∟ Cardiomyopathy, Restrictive \| ∟ Chagas Cardiomyopathy \| ∟ Endocardial Fibroelastosis \| ∟ Endomyocardial Fibrosis \| ∟ Glycogen Storage Disease Type IIb \| ∟ Myocardial Reperfusion Injury \| ∟ Myocarditis Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Central Nervous System Diseases ∟ Ocular Motility Disorders ∟ Ophthalmoplegia ∟ Ophthalmoplegia, Chronic Progressive External ∟ Kearns-Sayer Syndrome 11 coordinate concepts ∟ Usher Syndromes \| ∟ Cardiomyopathy, Alcoholic \| ∟ Cardiomyopathy, Dilated \| ∟ Cardiomyopathy, Hypertrophic \| ∟ Cardiomyopathy, Restrictive \| ∟ Chagas Cardiomyopathy \| ∟ Endocardial Fibroelastosis \| ∟ Endomyocardial Fibrosis \| ∟ Glycogen Storage Disease Type IIb \| ∟ Myocardial Reperfusion Injury \| ∟ Myocarditis Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Central Nervous System Diseases ∟ Ocular Motility Disorders ∟ Ophthalmoplegia, Chronic Progressive External ∟ Kearns-Sayer Syndrome 11 coordinate concepts ∟ Usher Syndromes \| ∟ Cardiomyopathy, Alcoholic \| ∟ Cardiomyopathy, Dilated \| ∟ Cardiomyopathy, Hypertrophic \| ∟ Cardiomyopathy, Restrictive \| ∟ Chagas Cardiomyopathy \| ∟ Endocardial Fibroelastosis \| ∟ Endomyocardial Fibrosis \| ∟ Glycogen Storage Disease Type IIb \| ∟ Myocardial Reperfusion Injury \| ∟ Myocarditis Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Cranial Nerve Diseases ∟ Ocular Motility Disorders ∟ Ophthalmoplegia ∟ Ophthalmoplegia, Chronic Progressive External ∟ Kearns-Sayer Syndrome 11 coordinate concepts ∟ Usher Syndromes \| ∟ Cardiomyopathy, Alcoholic \| ∟ Cardiomyopathy, Dilated \| ∟ Cardiomyopathy, Hypertrophic \| ∟ Cardiomyopathy, Restrictive \| ∟ Chagas Cardiomyopathy \| ∟ Endocardial Fibroelastosis \| ∟ Endomyocardial Fibrosis \| ∟ Glycogen Storage Disease Type IIb \| ∟ Myocardial Reperfusion Injury \| ∟ Myocarditis Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Cranial Nerve Diseases ∟ Ocular Motility Disorders ∟ Ophthalmoplegia, Chronic Progressive External ∟ Kearns-Sayer Syndrome 11 coordinate concepts ∟ Usher Syndromes \| ∟ Cardiomyopathy, Alcoholic \| ∟ Cardiomyopathy, Dilated \| ∟ Cardiomyopathy, Hypertrophic \| ∟ Cardiomyopathy, Restrictive \| ∟ Chagas Cardiomyopathy \| ∟ Endocardial Fibroelastosis \| ∟ Endomyocardial Fibrosis \| ∟ Glycogen Storage Disease Type IIb \| ∟ Myocardial Reperfusion Injury \| ∟ Myocarditis Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Neurologic Manifestations ∟ Paralysis ∟ Ophthalmoplegia ∟ Ophthalmoplegia, Chronic Progressive External ∟ Kearns-Sayer Syndrome 11 coordinate concepts ∟ Usher Syndromes \| ∟ Cardiomyopathy, Alcoholic \| ∟ Cardiomyopathy, Dilated \| ∟ Cardiomyopathy, Hypertrophic \| ∟ Cardiomyopathy, Restrictive \| ∟ Chagas Cardiomyopathy \| ∟ Endocardial Fibroelastosis \| ∟ Endomyocardial Fibrosis \| ∟ Glycogen Storage Disease Type IIb \| ∟ Myocardial Reperfusion Injury \| ∟ Myocarditis Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Neuromuscular Diseases ∟ Muscular Diseases ∟ Mitochondrial Myopathies ∟ Ophthalmoplegia, Chronic Progressive External ∟ Kearns-Sayer Syndrome 11 coordinate concepts ∟ Usher Syndromes \| ∟ Cardiomyopathy, Alcoholic \| ∟ Cardiomyopathy, Dilated \| ∟ Cardiomyopathy, Hypertrophic \| ∟ Cardiomyopathy, Restrictive \| ∟ Chagas Cardiomyopathy \| ∟ Endocardial Fibroelastosis \| ∟ Endomyocardial Fibrosis \| ∟ Glycogen Storage Disease Type IIb \| ∟ Myocardial Reperfusion Injury \| ∟ Myocarditis Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Mitochondrial Diseases ∟ Mitochondrial Myopathies ∟ Ophthalmoplegia, Chronic Progressive External ∟ Kearns-Sayer Syndrome 11 coordinate concepts ∟ Usher Syndromes \| ∟ Cardiomyopathy, Alcoholic \| ∟ Cardiomyopathy, Dilated \| ∟ Cardiomyopathy, Hypertrophic \| ∟ Cardiomyopathy, Restrictive \| ∟ Chagas Cardiomyopathy \| ∟ Endocardial Fibroelastosis \| ∟ Endomyocardial Fibrosis \| ∟ Glycogen Storage Disease Type IIb \| ∟ Myocardial Reperfusion Injury \| ∟ Myocarditis Medical Subject Headings (MeSH) ∟ Pathological Conditions, Signs and Symptoms ∟ Signs and Symptoms ∟ Neurologic Manifestations ∟ Paralysis ∟ Ophthalmoplegia ∟ Ophthalmoplegia, Chronic Progressive External ∟ Kearns-Sayer Syndrome 11 coordinate concepts ∟ Usher Syndromes \| ∟ Cardiomyopathy, Alcoholic \| ∟ Cardiomyopathy, Dilated \| ∟ Cardiomyopathy, Hypertrophic \| ∟ Cardiomyopathy, Restrictive \| ∟ Chagas Cardiomyopathy \| ∟ Endocardial Fibroelastosis \| ∟ Endomyocardial Fibrosis \| ∟ Glycogen Storage Disease Type IIb \| ∟ Myocardial Reperfusion Injury \| ∟ Myocarditis X
Broader terms:	Medical Subject Headings (MeSH) ∟ Cardiovascular Diseases ∟ Heart Diseases ∟ Cardiomyopathies ∟ Kearns-Sayer Syndrome Medical Subject Headings (MeSH) ∟ Congenital, Hereditary, and Neonatal Diseases and Abnormalities ∟ Genetic Diseases, Inborn ∟ Eye Diseases, Hereditary ∟ Retinitis Pigmentosa ∟ Kearns-Sayer Syndrome Medical Subject Headings (MeSH) ∟ Eye Diseases ∟ Eye Diseases, Hereditary ∟ Retinitis Pigmentosa ∟ Kearns-Sayer Syndrome Medical Subject Headings (MeSH) ∟ Eye Diseases ∟ Ocular Motility Disorders ∟ Ophthalmoplegia ∟ Ophthalmoplegia, Chronic Progressive External ∟ Kearns-Sayer Syndrome Medical Subject Headings (MeSH) ∟ Eye Diseases ∟ Ocular Motility Disorders ∟ Ophthalmoplegia, Chronic Progressive External ∟ Kearns-Sayer Syndrome Medical Subject Headings (MeSH) ∟ Eye Diseases ∟ Retinal Diseases ∟ Retinal Degeneration ∟ Retinitis Pigmentosa ∟ Kearns-Sayer Syndrome Medical Subject Headings (MeSH) ∟ Musculoskeletal Diseases ∟ Muscular Diseases ∟ Mitochondrial Myopathies ∟ Ophthalmoplegia, Chronic Progressive External ∟ Kearns-Sayer Syndrome Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Central Nervous System Diseases ∟ Ocular Motility Disorders ∟ Ophthalmoplegia ∟ Ophthalmoplegia, Chronic Progressive External ∟ Kearns-Sayer Syndrome Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Central Nervous System Diseases ∟ Ocular Motility Disorders ∟ Ophthalmoplegia, Chronic Progressive External ∟ Kearns-Sayer Syndrome Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Cranial Nerve Diseases ∟ Ocular Motility Disorders ∟ Ophthalmoplegia ∟ Ophthalmoplegia, Chronic Progressive External ∟ Kearns-Sayer Syndrome Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Cranial Nerve Diseases ∟ Ocular Motility Disorders ∟ Ophthalmoplegia, Chronic Progressive External ∟ Kearns-Sayer Syndrome Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Neurologic Manifestations ∟ Paralysis ∟ Ophthalmoplegia ∟ Ophthalmoplegia, Chronic Progressive External ∟ Kearns-Sayer Syndrome Medical Subject Headings (MeSH) ∟ Nervous System Diseases ∟ Neuromuscular Diseases ∟ Muscular Diseases ∟ Mitochondrial Myopathies ∟ Ophthalmoplegia, Chronic Progressive External ∟ Kearns-Sayer Syndrome Medical Subject Headings (MeSH) ∟ Nutritional and Metabolic Diseases ∟ Metabolic Diseases ∟ Mitochondrial Diseases ∟ Mitochondrial Myopathies ∟ Ophthalmoplegia, Chronic Progressive External ∟ Kearns-Sayer Syndrome Medical Subject Headings (MeSH) ∟ Pathological Conditions, Signs and Symptoms ∟ Signs and Symptoms ∟ Neurologic Manifestations ∟ Paralysis ∟ Ophthalmoplegia ∟ Ophthalmoplegia, Chronic Progressive External ∟ Kearns-Sayer Syndrome Cardiomyopathies > Heart Diseases > Cardiovascular Diseases > Medical Subject Headings (MeSH) Retinitis Pigmentosa > Eye Diseases, Hereditary > Genetic Diseases, Inborn > Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Medical Subject Headings (MeSH) Retinitis Pigmentosa > Eye Diseases, Hereditary > Eye Diseases > Medical Subject Headings (MeSH) Ophthalmoplegia, Chronic Progressive External > Ophthalmoplegia > Ocular Motility Disorders > Eye Diseases > Medical Subject Headings (MeSH) Ophthalmoplegia, Chronic Progressive External > Ocular Motility Disorders > Eye Diseases > Medical Subject Headings (MeSH) Retinitis Pigmentosa > Retinal Degeneration > Retinal Diseases > Eye Diseases > Medical Subject Headings (MeSH) Ophthalmoplegia, Chronic Progressive External > Mitochondrial Myopathies > Muscular Diseases > Musculoskeletal Diseases > Medical Subject Headings (MeSH) Ophthalmoplegia, Chronic Progressive External > Ophthalmoplegia > Ocular Motility Disorders > Central Nervous System Diseases > Nervous System Diseases > Medical Subject Headings (MeSH) Ophthalmoplegia, Chronic Progressive External > Ocular Motility Disorders > Central Nervous System Diseases > Nervous System Diseases > Medical Subject Headings (MeSH) Ophthalmoplegia, Chronic Progressive External > Ophthalmoplegia > Ocular Motility Disorders > Cranial Nerve Diseases > Nervous System Diseases > Medical Subject Headings (MeSH) Ophthalmoplegia, Chronic Progressive External > Ocular Motility Disorders > Cranial Nerve Diseases > Nervous System Diseases > Medical Subject Headings (MeSH) Ophthalmoplegia, Chronic Progressive External > Ophthalmoplegia > Paralysis > Neurologic Manifestations > Nervous System Diseases > Medical Subject Headings (MeSH) Ophthalmoplegia, Chronic Progressive External > Mitochondrial Myopathies > Muscular Diseases > Neuromuscular Diseases > Nervous System Diseases > Medical Subject Headings (MeSH) Ophthalmoplegia, Chronic Progressive External > Mitochondrial Myopathies > Mitochondrial Diseases > Metabolic Diseases > Nutritional and Metabolic Diseases > Medical Subject Headings (MeSH) Ophthalmoplegia, Chronic Progressive External > Ophthalmoplegia > Paralysis > Neurologic Manifestations > Signs and Symptoms > Pathological Conditions, Signs and Symptoms > Medical Subject Headings (MeSH) X
History note:	Heart Block (1966-1982) \| Ophthalmoplegia (1966-1982) \| Retinitis Pigmentosa (1966-1982)X
historyNote*:	2005 (1983) X
publicMeSHNote*:	2005; see KEARNS SYNDROME 1991-2004, see OPHTHALMOPLEGIA 1983-1990 X
Scope note:	A mitochondrial disorder featuring the triad of chronic progressive EXTERNAL OPHTHALMOPLEGIA, cardiomyopathy (CARDIOMYOPATHIES) with conduction block (HEART BLOCK), and RETINITIS PIGMENTOSA. Disease onset is in the first or second decade. Elevated CSF protein, sensorineural deafness, seizures, and pyramidal signs may also be present. Ragged-red fibers are found on muscle biopsy. (Adams et al., Principles of Neurology, 6th ed, p984) X
activeMeSHYear*:	2005 \| 2006 \| 2007X
dateCreated*:	1982-04-26X
dateEstablished*:	1991-01-01X
dateRevised*:	2004-07-07X
recordAuthorizer*:	sjnX
recordMaintainer*:	lktX
recordOriginator*:	RCX
Type:	Concept X
Coordinate terms:	Usher Syndromes \| Cardiomyopathy, Alcoholic \| Cardiomyopathy, Dilated \| Cardiomyopathy, Hypertrophic \| Cardiomyopathy, Restrictive \| Chagas Cardiomyopathy \| Endocardial Fibroelastosis \| Endomyocardial Fibrosis \| Glycogen Storage Disease Type IIb \| Myocardial Reperfusion Injury \| Myocarditis X
URI:	X
Labels and equivalent concepts:	Kearns-Sayerin oireyhtymä (fi) Kearnsin syndrooma (fi, replaced) Kearnsin oireyhtymä (fi, replaced) Kearns-Sayerin syndrooma (fi, replaced) Kearns-Sayers syndrom (sv) Kearns Syndrome (en, replaced) Kearns-Sayre-Shy-Daroff Syndrome (en, replaced) Kearns' Syndrome (en, replaced) Kearn-Sayre Mitochondrial Cytopathy (en, replaced) Syndroma Kearns (la-FI, replaced) Syndroma Kearns-Sayer (la-FI, replaced) X
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