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Ivermectin
Hierarchy: | ∟ ∟ ∟ ∟ Ivermectin 21 coordinate concepts∟ ∟ ∟ ∟ Ivermectin 21 coordinate concepts∟ ∟ ∟ ∟ Ivermectin 21 coordinate conceptsX |
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History note: | Anthelmintics (1966-1986) | Antinematodal Agents (1974-1986) | Antiprotozoal Agents (1966-1986) | Filaricides (1973-1986) | Insecticides (1966-1986) | Lactones (1966-1986)X |
historyNote*: | 1987; for MECTIZAN use IVERMECTIN (NM) 1987-1999
X |
publicMeSHNote*: | 1987; for MECTIZAN see IVERMECTIN 1987-1999
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Scope note: | A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
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activeMeSHYear*: | |
dateCreated*: | 1986-06-16X |
dateEstablished*: | 1987-01-01X |
dateRevised*: | 2005-06-30X |
recordAuthorizer*: | sjnX |
recordMaintainer*: | ssbX |
recordOriginator*: | RLSX |
Type: | |
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URI: | |
Labels and equivalent concepts: | Ivermektiini (fi) XIvermektin (sv) Merck Brand of Ivermectin (en, replaced) |
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