ONKI3 | Medical Subject Headings

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Isocitrate Dehydrogenase

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Oxidoreductases ∟ Alcohol Oxidoreductases ∟ Isocitrate Dehydrogenase 20 coordinate concepts ∟ 3-Hydroxyacyl CoA Dehydrogenases \| ∟ 3-Isopropylmalate Dehydrogenase \| ∟ Acetoin Dehydrogenase \| ∟ Alcohol Dehydrogenase \| ∟ Carbohydrate Dehydrogenases \| ∟ Choline Dehydrogenase \| ∟ Galactose Oxidase \| ∟ Glucose Oxidase \| ∟ Homoserine Dehydrogenase \| ∟ Hydroxybutyrate Dehydrogenase \| ∟ Hydroxyprostaglandin Dehydrogenases \| ∟ Hydroxypyruvate Reductase \| ∟ Hydroxysteroid Dehydrogenases \| ∟ IMP Dehydrogenase \| ∟ Ketol-Acid Reductoisomerase \| ∟ Lactate Dehydrogenases \| ∟ Malate Dehydrogenase \| ∟ Malate Dehydrogenase (NADP+) \| ∟ Xanthine Dehydrogenase \| ∟ Xanthine Oxidase X
Broader terms:	Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Oxidoreductases ∟ Alcohol Oxidoreductases ∟ Isocitrate Dehydrogenase Alcohol Oxidoreductases > Oxidoreductases > Enzymes > Enzymes and Coenzymes > Medical Subject Headings (MeSH) X
historyNote*:	65(63) X
publicMeSHNote*:	65 X
Scope note:	An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41. X
activeMeSHYear*:	2004 \| 2005 \| 2006 \| 2007X
dateCreated*:	1999-01-01X
dateEstablished*:	1965-01-01X
dateRevised*:	2003-07-09X
recordAuthorizer*:	sjnX
recordMaintainer*:	ssbX
recordOriginator*:	NLMX
Type:	Concept X
Coordinate terms:	3-Hydroxyacyl CoA Dehydrogenases \| 3-Isopropylmalate Dehydrogenase \| Acetoin Dehydrogenase \| Alcohol Dehydrogenase \| Carbohydrate Dehydrogenases \| Choline Dehydrogenase \| Galactose Oxidase \| Glucose Oxidase \| Homoserine Dehydrogenase \| Hydroxybutyrate Dehydrogenase \| Hydroxyprostaglandin Dehydrogenases \| Hydroxypyruvate Reductase \| Hydroxysteroid Dehydrogenases \| IMP Dehydrogenase \| Ketol-Acid Reductoisomerase \| Lactate Dehydrogenases \| Malate Dehydrogenase \| Malate Dehydrogenase (NADP+) \| Xanthine Dehydrogenase \| Xanthine Oxidase X
URI:	X
Labels and equivalent concepts:	Isositraattidehydrogenaasi (fi) Isositruunahappodehydrogenaasi (fi, replaced) Isocitratdehydrogenas (sv) NAD Isocitrate Dehydrogenase (en, replaced) Isocitrate Dehydrogenase (NAD+) (en, replaced) X
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