ONKI3 | Medical Subject Headings

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The way property values are displayed: value/row values side by side

The way concept relations are shown: separately in hierarchy

Heavy Chain Disease

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Hemic and Lymphatic Diseases ∟ Hematologic Diseases ∟ Blood Protein Disorders ∟ Paraproteinemias ∟ Heavy Chain Disease 22 coordinate concepts 1 subordinate concept ∟ Immunoproliferative Small Intestinal Disease ∟ Cryoglobulinemia \| ∟ Monoclonal Gammopathies, Benign \| ∟ Multiple Myeloma \| ∟ POEMS Syndrome \| ∟ Waldenstrom Macroglobulinemia \| ∟ Agammaglobulinemia \| ∟ Giant Lymph Node Hyperplasia \| ∟ Granuloma \| ∟ Immunoblastic Lymphadenopathy \| ∟ Immunoproliferative Small Intestinal Disease \| ∟ Infectious Mononucleosis \| ∟ Leukemia, Hairy Cell \| ∟ Leukemia, Lymphocytic \| ∟ Leukemia, Myeloid \| ∟ Leukemia, Plasmacytic \| ∟ Lymphangiomyoma \| ∟ Lymphoma \| ∟ Lymphomatoid Granulomatosis \| ∟ Marek Disease \| ∟ Sarcoidosis \| ∟ Sezary Syndrome \| ∟ Tumor Lysis Syndrome Medical Subject Headings (MeSH) ∟ Hemic and Lymphatic Diseases ∟ Lymphatic Diseases ∟ Lymphoproliferative Disorders ∟ Heavy Chain Disease 22 coordinate concepts 1 subordinate concept ∟ Immunoproliferative Small Intestinal Disease ∟ Cryoglobulinemia \| ∟ Monoclonal Gammopathies, Benign \| ∟ Multiple Myeloma \| ∟ POEMS Syndrome \| ∟ Waldenstrom Macroglobulinemia \| ∟ Agammaglobulinemia \| ∟ Giant Lymph Node Hyperplasia \| ∟ Granuloma \| ∟ Immunoblastic Lymphadenopathy \| ∟ Immunoproliferative Small Intestinal Disease \| ∟ Infectious Mononucleosis \| ∟ Leukemia, Hairy Cell \| ∟ Leukemia, Lymphocytic \| ∟ Leukemia, Myeloid \| ∟ Leukemia, Plasmacytic \| ∟ Lymphangiomyoma \| ∟ Lymphoma \| ∟ Lymphomatoid Granulomatosis \| ∟ Marek Disease \| ∟ Sarcoidosis \| ∟ Sezary Syndrome \| ∟ Tumor Lysis Syndrome Medical Subject Headings (MeSH) ∟ Immune System Diseases ∟ Immunoproliferative Disorders ∟ Lymphoproliferative Disorders ∟ Heavy Chain Disease 22 coordinate concepts 1 subordinate concept ∟ Immunoproliferative Small Intestinal Disease ∟ Cryoglobulinemia \| ∟ Monoclonal Gammopathies, Benign \| ∟ Multiple Myeloma \| ∟ POEMS Syndrome \| ∟ Waldenstrom Macroglobulinemia \| ∟ Agammaglobulinemia \| ∟ Giant Lymph Node Hyperplasia \| ∟ Granuloma \| ∟ Immunoblastic Lymphadenopathy \| ∟ Immunoproliferative Small Intestinal Disease \| ∟ Infectious Mononucleosis \| ∟ Leukemia, Hairy Cell \| ∟ Leukemia, Lymphocytic \| ∟ Leukemia, Myeloid \| ∟ Leukemia, Plasmacytic \| ∟ Lymphangiomyoma \| ∟ Lymphoma \| ∟ Lymphomatoid Granulomatosis \| ∟ Marek Disease \| ∟ Sarcoidosis \| ∟ Sezary Syndrome \| ∟ Tumor Lysis Syndrome Medical Subject Headings (MeSH) ∟ Immune System Diseases ∟ Immunoproliferative Disorders ∟ Paraproteinemias ∟ Heavy Chain Disease 22 coordinate concepts 1 subordinate concept ∟ Immunoproliferative Small Intestinal Disease ∟ Cryoglobulinemia \| ∟ Monoclonal Gammopathies, Benign \| ∟ Multiple Myeloma \| ∟ POEMS Syndrome \| ∟ Waldenstrom Macroglobulinemia \| ∟ Agammaglobulinemia \| ∟ Giant Lymph Node Hyperplasia \| ∟ Granuloma \| ∟ Immunoblastic Lymphadenopathy \| ∟ Immunoproliferative Small Intestinal Disease \| ∟ Infectious Mononucleosis \| ∟ Leukemia, Hairy Cell \| ∟ Leukemia, Lymphocytic \| ∟ Leukemia, Myeloid \| ∟ Leukemia, Plasmacytic \| ∟ Lymphangiomyoma \| ∟ Lymphoma \| ∟ Lymphomatoid Granulomatosis \| ∟ Marek Disease \| ∟ Sarcoidosis \| ∟ Sezary Syndrome \| ∟ Tumor Lysis Syndrome X
Broader terms:	Medical Subject Headings (MeSH) ∟ Hemic and Lymphatic Diseases ∟ Hematologic Diseases ∟ Blood Protein Disorders ∟ Paraproteinemias ∟ Heavy Chain Disease Medical Subject Headings (MeSH) ∟ Hemic and Lymphatic Diseases ∟ Lymphatic Diseases ∟ Lymphoproliferative Disorders ∟ Heavy Chain Disease Medical Subject Headings (MeSH) ∟ Immune System Diseases ∟ Immunoproliferative Disorders ∟ Lymphoproliferative Disorders ∟ Heavy Chain Disease Medical Subject Headings (MeSH) ∟ Immune System Diseases ∟ Immunoproliferative Disorders ∟ Paraproteinemias ∟ Heavy Chain Disease Paraproteinemias > Blood Protein Disorders > Hematologic Diseases > Hemic and Lymphatic Diseases > Medical Subject Headings (MeSH) Lymphoproliferative Disorders > Lymphatic Diseases > Hemic and Lymphatic Diseases > Medical Subject Headings (MeSH) Lymphoproliferative Disorders > Immunoproliferative Disorders > Immune System Diseases > Medical Subject Headings (MeSH) Paraproteinemias > Immunoproliferative Disorders > Immune System Diseases > Medical Subject Headings (MeSH) X
Narrower terms:	Immunoproliferative Small Intestinal Disease X
Annotation:	specify the immunoglobulin fragment coord NIM, as gamma chain dis = HEAVY CHAIN DISEASE (IM) + IMMUNOGLOBULIN GAMMA-CHAINS (NIM); ALPHA-CHAIN DISEASE see IMMUNOPROLIFERATIVE SMALL INTESTINAL DISEASE is available X
historyNote*:	66(64) X
publicMeSHNote*:	66 X
Scope note:	A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes. X
activeMeSHYear*:	2006 \| 2007X
dateCreated*:	1999-01-01X
dateEstablished*:	1966-01-01X
dateRevised*:	2005-07-01X
recordAuthorizer*:	sjnX
recordMaintainer*:	sjnX
recordOriginator*:	NLMX
Related term:	Immunoglobulin Heavy Chains X
Type:	Concept X
Coordinate terms:	Cryoglobulinemia \| Monoclonal Gammopathies, Benign \| Multiple Myeloma \| POEMS Syndrome \| Waldenstrom Macroglobulinemia \| Agammaglobulinemia \| Giant Lymph Node Hyperplasia \| Granuloma \| Immunoblastic Lymphadenopathy \| Immunoproliferative Small Intestinal Disease \| Infectious Mononucleosis \| Leukemia, Hairy Cell \| Leukemia, Lymphocytic \| Leukemia, Myeloid \| Leukemia, Plasmacytic \| Lymphangiomyoma \| Lymphoma \| Lymphomatoid Granulomatosis \| Marek Disease \| Sarcoidosis \| Sezary Syndrome \| Tumor Lysis Syndrome X
URI:	X
Labels and equivalent concepts:	Raskasketjutauti (fi) Gammaraskasketjutauti (fi, replaced) Franklinin tauti (fi, replaced) Tungkedjesjukdom (sv) Franklin's Disease (en, replaced) Franklin Disease (en, replaced) Morbus Franklin (la-FI, replaced) X
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