ONKI3 | Medical Subject Headings

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Gene Amplification

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Genetic Phenomena ∟ Variation (Genetics) ∟ Mutation ∟ Gene Amplification 35 coordinate concepts 1 subordinate concept ∟ D005784Q000379* ∟ DNA Repeat Expansion \| ∟ Gene Duplication \| ∟ Inversion, Chromosome \| ∟ Mutagenesis, Insertional \| ∟ Nondisjunction, Genetic \| ∟ Sequence Deletion \| ∟ Somatic Hypermutation, Immunoglobulin \| ∟ Suppression, Genetic \| ∟ Translocation, Genetic \| ∟ Chromatin Assembly and Disassembly \| ∟ Down-Regulation \| ∟ Epigenesis, Genetic \| ∟ Epistasis, Genetic \| ∟ Frameshifting, Ribosomal \| ∟ Gene Expression Regulation, Archaeal \| ∟ Gene Expression Regulation, Bacterial \| ∟ Gene Expression Regulation, Developmental \| ∟ Gene Expression Regulation, Enzymologic \| ∟ Gene Expression Regulation, Fungal \| ∟ Gene Expression Regulation, Neoplastic \| ∟ Gene Expression Regulation, Plant \| ∟ Gene Expression Regulation, Viral \| ∟ Protein Modification, Translational \| ∟ RNA Processing, Post-Transcriptional \| ∟ Trans-Activation (Genetics) \| ∟ Up-Regulation \| ∟ Allelic Imbalance \| ∟ Base Pair Mismatch \| ∟ Chromosome Aberrations \| ∟ Codon, Nonsense \| ∟ Frameshift Mutation \| ∟ Genomic Instability \| ∟ Germ-Line Mutation \| ∟ Mutation, Missense \| ∟ Point Mutation Medical Subject Headings (MeSH) ∟ Genetic Processes ∟ Gene Expression Regulation ∟ Gene Amplification 35 coordinate concepts 1 subordinate concept ∟ D005784Q000379* ∟ DNA Repeat Expansion \| ∟ Gene Duplication \| ∟ Inversion, Chromosome \| ∟ Mutagenesis, Insertional \| ∟ Nondisjunction, Genetic \| ∟ Sequence Deletion \| ∟ Somatic Hypermutation, Immunoglobulin \| ∟ Suppression, Genetic \| ∟ Translocation, Genetic \| ∟ Chromatin Assembly and Disassembly \| ∟ Down-Regulation \| ∟ Epigenesis, Genetic \| ∟ Epistasis, Genetic \| ∟ Frameshifting, Ribosomal \| ∟ Gene Expression Regulation, Archaeal \| ∟ Gene Expression Regulation, Bacterial \| ∟ Gene Expression Regulation, Developmental \| ∟ Gene Expression Regulation, Enzymologic \| ∟ Gene Expression Regulation, Fungal \| ∟ Gene Expression Regulation, Neoplastic \| ∟ Gene Expression Regulation, Plant \| ∟ Gene Expression Regulation, Viral \| ∟ Protein Modification, Translational \| ∟ RNA Processing, Post-Transcriptional \| ∟ Trans-Activation (Genetics) \| ∟ Up-Regulation \| ∟ Allelic Imbalance \| ∟ Base Pair Mismatch \| ∟ Chromosome Aberrations \| ∟ Codon, Nonsense \| ∟ Frameshift Mutation \| ∟ Genomic Instability \| ∟ Germ-Line Mutation \| ∟ Mutation, Missense \| ∟ Point Mutation Medical Subject Headings (MeSH) ∟ Genetic Processes ∟ Mutagenesis ∟ Gene Amplification 35 coordinate concepts 1 subordinate concept ∟ D005784Q000379* ∟ DNA Repeat Expansion \| ∟ Gene Duplication \| ∟ Inversion, Chromosome \| ∟ Mutagenesis, Insertional \| ∟ Nondisjunction, Genetic \| ∟ Sequence Deletion \| ∟ Somatic Hypermutation, Immunoglobulin \| ∟ Suppression, Genetic \| ∟ Translocation, Genetic \| ∟ Chromatin Assembly and Disassembly \| ∟ Down-Regulation \| ∟ Epigenesis, Genetic \| ∟ Epistasis, Genetic \| ∟ Frameshifting, Ribosomal \| ∟ Gene Expression Regulation, Archaeal \| ∟ Gene Expression Regulation, Bacterial \| ∟ Gene Expression Regulation, Developmental \| ∟ Gene Expression Regulation, Enzymologic \| ∟ Gene Expression Regulation, Fungal \| ∟ Gene Expression Regulation, Neoplastic \| ∟ Gene Expression Regulation, Plant \| ∟ Gene Expression Regulation, Viral \| ∟ Protein Modification, Translational \| ∟ RNA Processing, Post-Transcriptional \| ∟ Trans-Activation (Genetics) \| ∟ Up-Regulation \| ∟ Allelic Imbalance \| ∟ Base Pair Mismatch \| ∟ Chromosome Aberrations \| ∟ Codon, Nonsense \| ∟ Frameshift Mutation \| ∟ Genomic Instability \| ∟ Germ-Line Mutation \| ∟ Mutation, Missense \| ∟ Point Mutation X
Broader terms:	Medical Subject Headings (MeSH) ∟ Genetic Phenomena ∟ Variation (Genetics) ∟ Mutation ∟ Gene Amplification Medical Subject Headings (MeSH) ∟ Genetic Processes ∟ Gene Expression Regulation ∟ Gene Amplification Medical Subject Headings (MeSH) ∟ Genetic Processes ∟ Mutagenesis ∟ Gene Amplification Mutation > Variation (Genetics) > Genetic Phenomena > Medical Subject Headings (MeSH) Gene Expression Regulation > Genetic Processes > Medical Subject Headings (MeSH) Mutagenesis > Genetic Processes > Medical Subject Headings (MeSH) X
Narrower terms:	D005784Q000379* X
Annotation:	for physiol process only; for technique use NUCLEIC ACID AMPLIFICATION TECHNIQUES or specifics X
History note:	Genes (1966-1967) \| Genes, Structural (1968-1979) \| Nucleic Acid Hybridization (1971-1979) \| Plasmids (1975-1979)X
historyNote*:	80 X
publicMeSHNote*:	80 X
Scope note:	A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication. X
activeMeSHYear*:	2003 \| 2004 \| 2005 \| 2006 \| 2007X
dateCreated*:	1979-04-17X
dateEstablished*:	1980-01-01X
dateRevised*:	2002-07-02X
recordAuthorizer*:	sjnX
recordMaintainer*:	NDWX
recordOriginator*:	AEPX
Related term:	Gene Dosage X
Type:	Concept X
Coordinate terms:	DNA Repeat Expansion \| Gene Duplication \| Inversion, Chromosome \| Mutagenesis, Insertional \| Nondisjunction, Genetic \| Sequence Deletion \| Somatic Hypermutation, Immunoglobulin \| Suppression, Genetic \| Translocation, Genetic \| Chromatin Assembly and Disassembly \| Down-Regulation \| Epigenesis, Genetic \| Epistasis, Genetic \| Frameshifting, Ribosomal \| Gene Expression Regulation, Archaeal \| Gene Expression Regulation, Bacterial \| Gene Expression Regulation, Developmental \| Gene Expression Regulation, Enzymologic \| Gene Expression Regulation, Fungal \| Gene Expression Regulation, Neoplastic \| Gene Expression Regulation, Plant \| Gene Expression Regulation, Viral \| Protein Modification, Translational \| RNA Processing, Post-Transcriptional \| Trans-Activation (Genetics) \| Up-Regulation \| Allelic Imbalance \| Base Pair Mismatch \| Chromosome Aberrations \| Codon, Nonsense \| Frameshift Mutation \| Genomic Instability \| Germ-Line Mutation \| Mutation, Missense \| Point Mutation X
URI:	X
Labels and equivalent concepts:	Geenin monistuminen (fi) Geenin monistaminen (fi, replaced) Genamplifiering (sv) X
Share:	X