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Aromatase
Hierarchy: | ∟ ∟ ∟ ∟ ∟ ∟ ∟ Aromatase 10 coordinate concepts1 subordinate concept∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ Aromatase 10 coordinate concepts1 subordinate concept∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ Aromatase 10 coordinate concepts1 subordinate concept∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ Aromatase 10 coordinate concepts1 subordinate concept∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ |
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historyNote*: | 86(75); was see under OXIDOREDUCTASES 1975-85
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publicMeSHNote*: | 86; was see under OXIDOREDUCTASES 1975-85
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Scope note: | An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
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activeMeSHYear*: | |
dateCreated*: | 1974-11-19X |
dateEstablished*: | 1986-01-01X |
dateRevised*: | 2004-07-07X |
recordAuthorizer*: | sjnX |
recordMaintainer*: | ssbX |
recordOriginator*: | NLMX |
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Labels and equivalent concepts: | Aromataasi (fi) XAromatas (sv) Cytochrome P450 19 (en, replaced) Estrogen Synthase (en, replaced) Estrogen Synthetase (en, replaced) P450AROM (en, replaced) Cytochrome P-450(AROM) (en, replaced) Cytochrome P-450 CYP19 (en, replaced) CYP 19 (en, replaced) CYP19 (en, replaced) CYP19 Protein (en, replaced) Androstenedione Aromatase (en, replaced) |
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