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The way concept relations are shown:
Focal Adhesion Kinase 1
Hierarchy: | ∟ ∟ ∟ ∟ ∟ Focal Adhesion Kinase 1 26 coordinate concepts∟ ∟ ∟ ∟ ∟ Focal Adhesion Kinase 1 26 coordinate concepts∟ ∟ ∟ ∟ Focal Adhesion Kinase 1 26 coordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ Focal Adhesion Kinase 1 26 coordinate conceptsX |
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historyNote*: | 2006(1986)
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publicMeSHNote*: | 2006; ENDOGENOUS SUBSTRATE PP120, FOCAL ADHESION-ASSOCIATED, PROTEIN-TYROSINE KINASE PP125FAK, & P125FAK PROTEIN were indexed under PROTEIN-TYROSINE KINASE 2001-2005, & under CELL ADHESION MOLECULES 1990-2000, & MEMBRANE GLYCOPROTEINS 1987-1992, MEMBRANE PROTEINS 1986-1987
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Scope note: | A non-receptor protein tyrosine kinase that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.
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activeMeSHYear*: | |
dateCreated*: | 2005-06-30X |
dateEstablished*: | 2006-01-01X |
dateRevised*: | 2005-07-18X |
recordAuthorizer*: | agsX |
recordMaintainer*: | agsX |
recordOriginator*: | DRCX |
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Labels and equivalent concepts: | Fokaalinen adheesiokinaasi 1 (fi) Xp125FAK Protein (en, replaced) Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK (en, replaced) Endogenous Substrate pp120 (en, replaced) |
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