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The way concept relations are shown:
Cytochrome P-450 CYP1A2
Hierarchy: | ∟ ∟ ∟ ∟ ∟ ∟ ∟ Cytochrome P-450 CYP1A2 8 coordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ Cytochrome P-450 CYP1A2 8 coordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ Cytochrome P-450 CYP1A2 8 coordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ |
Broader terms: | |
Annotation: | do not confuse with other cytochrome P-450 CYP's
X |
History note: | |
historyNote*: | 97; was PHENACETIN O-DEALKYLASE (NM) 1976-96
X |
onlineNote*: | use CYTOCHROME P-450 CYP1A2 (NM) to search PHENACETIN O-DEALKYLASE 1980-96
X |
publicMeSHNote*: | 97; PHENACETIN O-DEALKYLASE was indexed under OXIDOREDUCTASES 1980-96, CYTOCHROME P-450 1976-96, & PHENACETIN 1976-80
X |
Scope note: | A cytochrome P-450 monooxygenase that can be induced by polycyclic aromatic xenobiotics in the liver of human and several animal species. This enzyme is of significant clinical interest due to the large number of drug interactions associated with its induction and its metabolism of THEOPHYLLINE. Caffeine is considered to be a model substrate for this enzyme. CYP1A2 activity can also be increased by environmental factors such as cigarette smoking, charbroiled meat, cruciferous vegetables, and a number of drugs including phenytoin, phenobarbital, and omeprazole.
X |
activeMeSHYear*: | |
dateCreated*: | 1996-06-24X |
dateEstablished*: | 1997-01-01X |
dateRevised*: | 2004-07-13X |
recordAuthorizer*: | sjnX |
recordMaintainer*: | sjnX |
recordOriginator*: | ADPX |
Type: | |
Coordinate terms: | |
URI: | |
Labels and equivalent concepts: | Sytokromi P-450 CYP1A2 (fi) XCytochrome P450 1A2 (en, replaced) Cytochrome P-450d (en, replaced) Phenacetin O-Dealkylase (en, replaced) Cytochrome P-450 LM4 (en, replaced) Cytochrome P-450 LM(4) (en, replaced) Caffeine Demethylase (en, replaced) CYP 1A2 (en, replaced) CYP1A2 (en, replaced) Citocromo P-450 CYP1A2 (es) Cytochrom P-450 CYP1A2 (de) cytochrom P-450 CYP1A2 (cs) CYP1A2 (es, replaced) Fenacetina O-Dealcilasa (es, replaced) Phenacetin-O-Dealkylase (de, replaced) CYP1A2 (de, replaced) |
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