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Amyloid beta-Protein Precursor
Hierarchy: | ∟ ∟ ∟ ∟ ∟ Amyloid beta-Protein Precursor 9 coordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ Amyloid beta-Protein Precursor 9 coordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ Amyloid beta-Protein Precursor 9 coordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ |
Broader terms: | |
Annotation: | /drug eff /ultrastruct permitted; DF: ABPP
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History note: | |
historyNote*: | 92; was AMYLOID BETA PROTEIN PRECURSOR (NM) 1988-91; AMYLOID A4 PROTEIN PRECURSOR was NM 1987-94
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onlineNote*: | use AMYLOID BETA-PROTEIN PRECURSOR (NM) to search AMYLOID BETA-PROTEIN PRECURSOR 1988-91 & AMYLOID A4 PROTEIN PRECURSOR 1987-94
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publicMeSHNote*: | 92; AMYLOID BETA-PROTEIN PRECURSOR was indexed under AMYLOID BETA-PROTEIN 1990-91 and AMYLOID & PROTEIN PRECURSORS 1988-91; AMYLOID A4 PROTEIN PRECURSOR was indexed under AMYLOID BETA-PROTEIN PRECURSOR 1993-94, AMYLOID BETA-PROTEIN 1991-92, PROTEIN PRECURSORS 1987-92, & AMYLOID 1987-90
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Scope note: | A precursor to the AMYLOID-BETA PROTEIN (beta/A4). Alterations in the expression of the amyloid beta-protein precursor (ABPP) gene, located on chromosome 21, plays a role in the development of the neuropathology common to both ALZHEIMER DISEASE and DOWN SYNDROME. ABPP is associated with the extensive extracellular matrix secreted by neuronal cells. Upon cleavage, this precursor produces three proteins of varying amino acid lengths: 695, 751, and 770. The beta/A4 (695 amino acids) or beta-amyloid protein is the principal component of the extracellular amyloid in senile plaques found in ALZHEIMER DISEASE; DOWN SYNDROME and, to a limited extent, in normal aging.
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activeMeSHYear*: | |
dateCreated*: | 1991-07-12X |
dateEstablished*: | 1992-01-01X |
dateRevised*: | 2004-07-07X |
recordAuthorizer*: | sjnX |
recordMaintainer*: | nnsX |
recordOriginator*: | MXRX |
Type: | |
Coordinate terms: | |
URI: | |
Labels and equivalent concepts: | Amyloidibeetaproteiinin esiaste (fi) Xbeta-Amyloid Protein Precursor (en, replaced) Amyloid Protein Precursor (en, replaced) Amyloid beta Precursor Protein (en, replaced) Amyloid A4 Protein Precursor (en, replaced) Precursor de Proteína-beta Amiloide (es) πρόδρομος βήτα αμυλοειδούς πρωτεΐνης (el) Amyloid-Beta-Protein-Vorstufe (de) amyloidní beta-protein - prekursor (cs) Precursor de beta-Proteína Amiloide (es, replaced) Precursor de la Proteína Amiloide (es, replaced) Precursor de la Proteína Amiloide A4 (es, replaced) Amyloidprotein-Präkursor (de, replaced) Beta-Amyloid-Protein-Präkursor (de, replaced) Amyloid-A4-Protein-Präkursor (de, replaced) |
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